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Ex vivo cultured megakaryocytes express functional glycoprotein IIb-IIIa receptors and are capable of adenovirus-mediated transgene expression

Autor: N, Faraday, J J, Rade, D C, Johns, G, Khetawat, S J, Noga, J F, DiPersio, Y, Jin, J L, Nichol, J S, Haug, P F, Bray

Publikováno v: Blood. 94(12)

Investigation of the molecular basis of megakaryocyte (MK) and platelet biology has been limited by an inadequate source of genetically manipulable cells exhibiting physiologic MK and platelet functions. We hypothesized that ex vivo cultured MKs woul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49225a653d9bfb6b486c7f9024cc91f5
https://pubmed.ncbi.nlm.nih.gov/10590053

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Specific signals generated by the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor are not required for G-CSF-dependent granulocytic differentiation

Autor: J, Jacob, J S, Haug, S, Raptis, D C, Link

Publikováno v: Blood. 92(2)

Granulocyte colony-stimulating factor (G-CSF) is the principal growth factor regulating the production of neutrophils, yet its role in lineage commitment and terminal differentiation of hematopoietic progenitor cells is controversial. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bff1e00aee11eb1879e75064ac45f5ab
https://pubmed.ncbi.nlm.nih.gov/9657731

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