Zobrazeno 1 - 10
of 68
pro vyhledávání: '"J S, Gutkind"'
Autor:
Jonathan W. Riess, Pilar Santisteban, C. Gomez, K. N. Shah, Trever G. Bivona, L. Cech, Victor Olivas, C. Fernandez-Mendez, Caroline E. McCoach, Mourad Majidi, Jack A. Roth, Jeroen P. Roose, Calvin J. Kuo, Shigeki Nanjo, Wei Wu, K. A. Herrington, Julia K Rotow, Juan Guan, J. S. Gutkind, D. L. Kerr, Ismail M. Meraz, Oghenekevwe Gbenedio, T. T. Tang, Bihua Huang, Hani Goodarzi, D. V. Allegakoen, Collin M. Blakely, Sourav Bandyopadhyay, W. Tamaki, Franziska Haderk, D. Barbosa Rabago, Jane A. Yu, L. Post
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7779f98eafcf3016a00cbcb9bd19930
https://doi.org/10.1101/2021.10.23.465573
https://doi.org/10.1101/2021.10.23.465573
Autor:
Chai Phei Gan, J. S. Gutkind, Stephen S. Prime, Z.A. Abdul Rahman, Muhammad Zaki Hidayatullah Fadlullah, Joon Liang Tan, Aik Choon Tan, Sok Ching Cheong, Jit Kang Chang, Tsung Fei Khang, Bernard Kok Bang Lee, Chee Sun Liew
Publikováno v:
Journal of Dental Research. 97:909-916
Head and neck cancer (HNC)–derived cell lines represent fundamental models for studying the biological mechanisms underlying cancer development and precision therapies. However, mining the genomic information of HNC cells from available databases r
Autor:
J S Gutkind, N J D'Silva
Publikováno v:
Adv Dent Res
Head and neck cancers are among the 10 most common cancers in the world and include cancers of the oral cavity, hypopharynx, larynx, nasopharynx, and oropharynx. At least 90% of head and neck cancers are squamous cell carcinomas (SCCs). This summary
Autor:
J. S. Gutkind, Jacques E. Nör
Publikováno v:
Journal of Dental Research. 97:601-602
Publikováno v:
Oncogene. 26:3240-3253
The mitogen-activated protein kinases (MAPKs) are a family of serine/threonine kinases that play an essential role in signal transduction by modulating gene transcription in the nucleus in response to changes in the cellular environment. They include
Publikováno v:
Journal of Biological Chemistry. 275:21730-21736
The regulation of gene expression by cell surface receptors often involves the stimulation of signaling pathways including one or more members of the MAPK superfamily of serine-threonine kinases. Upon their activation in the cytosol, MAPKs can transl
Publikováno v:
Molecular and Cellular Biology. 20:1747-1758
The serine/threonine kinase Cot is a member of the mitogen-activated protein kinase (MAPK) kinase kinase family implicated in cellular transformation. Enhanced expression of this protein has been shown to activate both the MAPK and the c-Jun N-termin
Publikováno v:
Molecular and Cellular Biology. 19:4289-4301
The expression of the c-jun proto-oncogene is rapidly induced in response to mitogens acting on a large variety of cell surface receptors. The resulting functional activity of c-Jun proteins appears to be critical for cell proliferation. Recently, we
Autor:
Teresa L.Z. Jones, J. S. Gutkind
Publikováno v:
Biochemistry. 37:3196-3202
The alpha subunit of the heterotrimeric G protein G12, harboring a mutation in the GTP binding domain (Q229L), behaves as a potent oncogene in NIH 3T3 cells. This alpha subunit, like most other G protein alpha subunits, undergoes palmitoylation, the
Autor:
J S Gutkind
Publikováno v:
Journal of Biological Chemistry. 273:1839-1842