Zobrazeno 1 - 10
of 48
pro vyhledávání: '"J S, Dileep Kumar"'
Autor:
Vidya Narayanaswami, Junchao Tong, Ferdinando Fiorino, Beatrice Severino, Rosa Sparaco, Elisa Magli, Flavia Giordano, Peter M. Bloomfield, Jaya Prabhakaran, J. John Mann, Neil Vasdev, Kenneth Dahl, J. S. Dileep Kumar
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-17 (2020)
Abstract Background Serotonin 1A (5-HT1A) receptors are implicated in the pathogenesis of several psychiatric and neurodegenerative disorders motivating the development of suitable radiotracers for in vivo positron emission tomography (PET) neuroimag
Externí odkaz:
https://doaj.org/article/d04212c45a1c477c855f4b83967b0456
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2922-2927 (2017)
Continuous-flow microfluidics has shown increased applications in radiochemistry over the last decade, particularly for both pre-clinical and clinical production of fluorine-18 labeled radiotracers. The main advantages of microfluidics are the reduct
Externí odkaz:
https://doaj.org/article/f2d3b8f0f0bc4f6984684e32c5bebcdd
Autor:
Andrei Molotkov, J. S. Dileep Kumar, Michael C. Salling, Jaya Prabhakaran, Akiva Mintz, Patrick Carberry, John Castrillon
Publikováno v:
Pharmacological Reports. 74:241-247
BACKGROUND Excessive alcohol consumption is a global health burden and requires a better understanding of its neurobiology. A lower density of brain microtubules is found in alcohol-related human brain disease postmortem and in rodent models of chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdeab2f16ec09c442e9c44ff31a06b7b
https://doi.org/10.1007/s43440-021-00311-6
https://doi.org/10.1007/s43440-021-00311-6
Autor:
J S, Dileep Kumar, Andrei, Molotkov, Patrick, Carberry, Thomas, Chaly, Ramesh, Neelamegam, Akiva, Mintz
Publikováno v:
Bioorganicmedicinal chemistry letters. 74
Combinations of antiangiogenic and cytotoxic agents show promising results in the treatment of cancer. However, there is a lack of single agent with both antiangiogenic and cytotoxic activities for clinical application. AG-488 aka FLAG-003 is a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b08b58fc6f2eae76728284ccdf64817b
https://pubmed.ncbi.nlm.nih.gov/35964845
https://pubmed.ncbi.nlm.nih.gov/35964845
Autor:
Jongho Kim, Mikhail Doubrovin, J. John Mann, Jaya Prabhakaran, Andrei Molotkov, Anirudh Sattiraju, Akiva Mintz, J. S. Dileep Kumar
Publikováno v:
Pharmacological Reports. 72:1433-1440
The upregulation of cyclooxygenase-2 (COX-2) is involved in neuroinflammation associated with many neurological diseases as well as cancers of the brain. Outside the brain, inflammation and COX-2 induction contribute to the pathogenesis of pain, arth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ad84cc52ba7c91005c81e62ec160e82
https://doi.org/10.1007/s43440-020-00124-z
https://doi.org/10.1007/s43440-020-00124-z
Autor:
J. S. Dileep Kumar, Bing Bai, Francesca Zanderigo, Christine DeLorenzo, Jaya Prabhakaran, Ramin V. Parsey, J. John Mann
Publikováno v:
Molecules, Vol 23, Iss 8, p 1929 (2018)
COX-2 selective inhibitors (COXIBs) are non-steroidal anti-inflammatory drugs (NSAIDs), with fewer side effects compared with non-selective NSAIDs, and are used for the treatment of arthritis, headaches, and other inflammatory diseases of the brain a
Externí odkaz:
https://doaj.org/article/4e1284494a2f40bc989e1db046d513f8
Autor:
Justin W. Hines, Naresh Damuka, Jaya Prabhakaran, J. S. Dileep Kumar, Kiran Kumar Solingapuram Sai, Steven J. Kridel, J. John Mann, Akiva Mintz
Publikováno v:
International Journal of Pharmacy and Pharmaceutical Sciences. :43-47
Objective: The objective of this study was to evaluate the uptake and specificity of [11C]MPC-6827, a MT targeted PET ligand in prostate, glioblastoma and breast cancer cells. Methods: [11C]MPC-6827 was synthesized by reacting corresponding desmethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c5bd57de04961e45a3530a5d9d857ec
https://doi.org/10.22159/ijpps.2020v12i1.35657
https://doi.org/10.22159/ijpps.2020v12i1.35657
Autor:
Kiran Kumar Solingapuram Sai, Akiva Mintz, J. S. Dileep Kumar, J. John Mann, Anirudh Sattiraju, Jaya Prabhakaran
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:778-781
Dysfunction of GSK3 is implicated in the etiology of many brain, inflammatory, cardiac diseases, and cancer. PET imaging would enable in vivo detection and quantification of GSK3 and can impact the choice of therapy, allow non-invasive monitoring of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86a9453f7e1dc307283cb559d7ca46aa
https://doi.org/10.1016/j.bmcl.2019.01.033
https://doi.org/10.1016/j.bmcl.2019.01.033
Autor:
Jaya Prabhakaran, Harry Rubin-Falcone, J. S. Dileep Kumar, J. John Mann, Francesca Zanderigo, Ramin V. Parsey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3592-3595
Overexpression of Cyclooxygenase-2 (COX-2) enzyme is associated with the pathogenesis of inflammation, cancers, stroke, arthritis, and neurological disorders. Because of the involvement of COX-2 in these diseases, quantification of COX-2 expression u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9558b07bd0fcddb607dd08be75e393
https://doi.org/10.1016/j.bmcl.2018.10.049
https://doi.org/10.1016/j.bmcl.2018.10.049
Autor:
J S, Dileep Kumar, Andrei, Molotkov, Michael C, Salling, Patrick, Carberry, Jaya, Prabhakaran, John, Castrillon, Akiva, Mintz
Publikováno v:
Pharmacol Rep
BACKGROUND: Excessive alcohol consumption is a global health burden and requires a better understanding of its neurobiology. A lower density of brain microtubules is found in alcohol-related human brain disease postmortem and in rodent models of chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d4ee3ed82b57ad7519a7d0010a02d57
https://pubmed.ncbi.nlm.nih.gov/34491568
https://pubmed.ncbi.nlm.nih.gov/34491568