Zobrazeno 1 - 10
of 351
pro vyhledávání: '"J S, Cooper"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundDementia with Lewy bodies (DLB) can be difficult to distinguish from Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD) at different stages of its progression due to some overlaps in the clinical and neuropathological prese
Externí odkaz:
https://doaj.org/article/dc0b770d0c4c4f41a9adf842be695bbb
Autor:
Melissa Scholefield, Stephanie J. Church, George Taylor, David Knight, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, most commonly characterised by motor dysfunction, but also with a high prevalence of cognitive decline in the decades following diagnosis—a condition known as
Externí odkaz:
https://doaj.org/article/f02d70b9f7a349db9090cc49b4e80243
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionVascular dementia (VaD) is one of the most common causes of dementia among the elderly. Despite this, the molecular basis of VaD remains poorly characterized when compared to other age-related dementias. Pervasive cerebral elevations of u
Externí odkaz:
https://doaj.org/article/7512390f6448457da5107a8761bc0857
Pan-cerebral sodium elevations in vascular dementia: Evidence for disturbed brain-sodium homeostasis
Autor:
Sasha A. Philbert, Jingshu Xu, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Vascular dementia (VaD) is the second most common cause of cognitive impairment amongst the elderly. However, there are no known disease-modifying therapies for VaD, probably due to incomplete understanding of the molecular basis of the disease. Desp
Externí odkaz:
https://doaj.org/article/55008665761749babd1effdcee0407a7
Autor:
Crystal Sang, Sasha A. Philbert, Danielle Hartland, Richard. D Unwin, Andrew W. Dowsey, Jingshu Xu, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Sporadic Alzheimer’s disease (sAD) is the commonest cause of age-related neurodegeneration and dementia globally, and a leading cause of premature disability and death. To date, the quest for a disease-modifying therapy for sAD has failed, probably
Externí odkaz:
https://doaj.org/article/23ea4691927649bf8e7e8c7447505224
Autor:
Zhanxuan E. Wu, Karl Fraser, Marlena C. Kruger, Ivana R. Sequeira, Wilson Yip, Louise W. Lu, Lindsay D. Plank, Rinki Murphy, Garth J. S. Cooper, Jean-Charles Martin, Sally D. Poppitt
Publikováno v:
Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-19 (2020)
Abstract Background Asian Chinese are more susceptible to deposition of visceral adipose tissue (VAT) and type 2 diabetes (T2D) development than European Caucasians when matched for gender, age and body mass index (BMI). Our aims were: (i) characteri
Externí odkaz:
https://doaj.org/article/b64f0bc891904baabe82ec67e5b70b93
Autor:
Ivana R. Sequeira, Wilson C. Yip, Louise W. W. Lu, Yannan Jiang, Rinki Murphy, Lindsay D. Plank, Garth J. S. Cooper, Carl N. Peters, Jun Lu, Kieren G. Hollingsworth, Sally D. Poppitt
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
ObjectivePrevalence of type 2 diabetes (T2D) is disproportionately higher in younger outwardly lean Asian Chinese compared to matched Caucasians. Susceptibility to T2D is hypothesised due to dysfunctional adipose tissue expansion resulting in adverse
Externí odkaz:
https://doaj.org/article/00ad65214d4e48a7bdac740388fcf2ea
Autor:
Ivana R Sequeira, Wilson Yip, Louise W Lu, Yannan Jiang, Rinki Murphy, Lindsay D Plank, Garth J S Cooper, Carl N Peters, Benjamin S Aribsala, Kieren G Hollingsworth, Sally D Poppitt
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279085 (2022)
ObjectiveWhile there is an emerging role of pancreatic fat in the aetiology of type 2 diabetes mellitus (T2DM), its impact on the associated decrease in insulin secretion remains controversial. We aimed to determine whether pancreatic fat negatively
Externí odkaz:
https://doaj.org/article/80b107414846425aa4d93915af84dce6
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stephanie J. Church, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Vascular dementia (VaD) is thought to be the second most common cause of age-related dementia amongst the elderly. However, at present, there are no available disease-modifying therapies for VaD, probably due to insufficient understanding about the m
Externí odkaz:
https://doaj.org/article/39efd04749634e7b828ce0cb6c4e5f5b
Autor:
Tina Nie, Garth J. S. Cooper
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Polyphenolic compounds are thought to show considerable promise for the treatment of various metabolic disorders, including type 2 diabetes mellitus (T2DM). This review addresses evidence from in vitro, in vivo, and clinical studies for the antidiabe
Externí odkaz:
https://doaj.org/article/6e7b31fc39814eb0b8814962b697603a