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Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form

Autor: J S, Beebe, K, Mountjoy, R F, Krzesicki, F, Perini, R W, Ruddon

Publikováno v: The Journal of biological chemistry. 265(1)

The malignant trophoblastic cell line JAR was used as a model system to study protein folding in intact cells. We have used this model previously to identify conformational intermediates in the production of an assembly-competent form of the human ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d94d2f423439b4afca8794a49cf4bcb
https://pubmed.ncbi.nlm.nih.gov/1688430

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Detection of a glycosylated, incompletely folded form of chorionic gonadotropin beta subunit that is a precursor of hormone assembly in trophoblastic cells

Autor: R W, Ruddon, R F, Krzesicki, S E, Norton, J S, Beebe, B P, Peters, F, Perini

Publikováno v: The Journal of biological chemistry. 262(26)

The alpha and beta subunits of human chorionic gonadotropin are secreted both as a combined, noncovalently linked dimer form as well as uncombined, free forms by human trophoblastic cells. We have utilized the cultured choriocarcinoma cell line JAR t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2c0a537efb1ca1fe1c717102d0a522a
https://pubmed.ncbi.nlm.nih.gov/3624271

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