Zobrazeno 1 - 10
of 22
pro vyhledávání: '"J S, Althaus"'
Publikováno v:
Journal of Inherited Metabolic Disease. 21:587-597
CuZn superoxide dismutase (CuZn SOD) is one of several antioxidant enzymes that defend the cell against damage by oxygen free radicals. Mutations of the SOD1 gene encoding CuZn SOD are found in patients with familial amyotrophic lateral sclerosis (FA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56331624d407467766ca4a0e3676bd86
https://doi.org/10.1023/a:1005475206997
https://doi.org/10.1023/a:1005475206997
Autor:
J. S. Althaus, Terrence A. Scahill, Jacob Szmuszkovicz, P. F. Von Voigtlander, Wuyi Wang, A. Ghosh, Jeremiah P. Freeman, Stephen A. Mizsak
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cecdb2db47ad6159b3b443960fb3c7ea
https://doi.org/10.1002/chin.199208289
https://doi.org/10.1002/chin.199208289
Publikováno v:
Amino acids. 14(1-3)
Dopa and related catecholamines and their degradation products have been demonstrated to have neurotoxic potential in a number of cellular and in vivo experiments. Several mechanisms have been hypothesized to be involved including generation of proox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45560aac2af079e67c75490f15e7d0e
https://pubmed.ncbi.nlm.nih.gov/9871460
https://pubmed.ncbi.nlm.nih.gov/9871460
Autor:
E D, Hall, P K, Andrus, S L, Smith, T J, Fleck, H M, Scherch, B S, Lutzke, G A, Sawada, J S, Althaus, P F, Vonvoigtlander, G E, Padbury, P G, Larson, J R, Palmer, G L, Bundy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(2)
A novel group of antioxidant compounds, the pyrrolopyrimidines, has been discovered recently. Many of these possess significantly improved oral bioavailability (56-70% in rats), increased efficacy and potency in protecting cultured neurons against ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda9d59b6e3e37f452e3b016753fb48c
https://pubmed.ncbi.nlm.nih.gov/9152399
https://pubmed.ncbi.nlm.nih.gov/9152399
Publikováno v:
Research communications in molecular pathology and pharmacology. 91(3)
Following CNS trauma or ischemia, peroxynitrite may be a toxic intermediate which forms in vivo when nitric oxide condenses with superoxide. Alone, peroxynitrite appears to directly react with aromatic and sulfhydryl nucleophiles. However, at physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4d37bfc5acfe56c64b2e63a8fa92f96
https://pubmed.ncbi.nlm.nih.gov/8829775
https://pubmed.ncbi.nlm.nih.gov/8829775
Publikováno v:
Research communications in molecular pathology and pharmacology. 87(3)
Peroxynitrite may be a physiologically relevant endogenous neurotoxin that forms following CNS trauma when excessive levels of NO and .O2 accumulate. Recently, peroxynitrite was found to inactivate the polyclonal antibody to cAMP. A feasibility study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::444b87467c82f8d677b51f55d4e609b2
https://pubmed.ncbi.nlm.nih.gov/7620829
https://pubmed.ncbi.nlm.nih.gov/7620829
Publikováno v:
Research communications in chemical pathology and pharmacology. 83(3)
Nitric oxide (NO) is made by NO synthase during the conversion of arginine to citrulline. Researchers have found that they can block the actions of excitotoxins by inhibiting NO synthase. Released from excitable cells during trauma, NO may react with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb213376554f07e1aaec182c445e65fe
https://pubmed.ncbi.nlm.nih.gov/8008974
https://pubmed.ncbi.nlm.nih.gov/8008974
Publikováno v:
Research communications in chemical pathology and pharmacology. 79(2)
We examined the effects of 6-hydroxydopamine (6-OHDA) treatment on the human neuroblastoma cell line SK-N-SH-SY5Y (SY5Y) and the rat pheochromocytoma cell line, PC12. Structural and metabolic integrity was tested by measuring the ability of cells to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f6c6e6174420e96efd0d687d200af65
https://pubmed.ncbi.nlm.nih.gov/8451541
https://pubmed.ncbi.nlm.nih.gov/8451541
Publikováno v:
Research communications in chemical pathology and pharmacology. 78(2)
Kappa opioid agonists are known to inhibit dopamine release. We sought to determine the site of this action and the relationship of tolerance to this effect. Microdialysis perfusion of the nucleus accumbens in unanesthetized rats was used to monitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5945919c740df3e63d60233b24817f8e
https://pubmed.ncbi.nlm.nih.gov/1282270
https://pubmed.ncbi.nlm.nih.gov/1282270
Autor:
M W, Moon, J K, Morris, R F, Heier, C G, Chidester, W E, Hoffmann, M F, Piercey, J S, Althaus, P F, Von Voigtlander, D L, Evans, L M, Figur
Publikováno v:
Journal of medicinal chemistry. 35(6)
The synthesis of 5-(dipropylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij] quinolin-2(1H)-one (5), a potent dopamine D2 agonist showing high dopamine/serotonin (5HT1A) selectivity, is described. Dopaminergic activity is associated with the (R)-enantiomer of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6209ac10169732f76179fab0fd972ef
https://pubmed.ncbi.nlm.nih.gov/1348089
https://pubmed.ncbi.nlm.nih.gov/1348089