Zobrazeno 1 - 10
of 126
pro vyhledávání: '"J Robert Lane"'
Autor:
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
Publikováno v:
eLife, Vol 9 (2020)
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r
Externí odkaz:
https://doaj.org/article/22ae5702392642ec91760a357236acbd
Publikováno v:
Cells, Vol 9, Iss 11, p 2400 (2020)
Understanding the link between agonist-induced phosphorylation of the mu-opioid receptor (MOR) and the associated physiological effects is critical for the development of novel analgesic drugs and is particularly important for understanding the mecha
Externí odkaz:
https://doaj.org/article/824c4c2f05f54840bce7eaf516bf6374
Autor:
Ravi Kumar Verma, Ara M Abramyan, Mayako Michino, R Benjamin Free, David R Sibley, Jonathan A Javitch, J Robert Lane, Lei Shi
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 1, p e1005948 (2018)
The dopamine D2 and D3 receptors (D2R and D3R) are important targets for antipsychotics and for the treatment of drug abuse. SB269652, a bitopic ligand that simultaneously binds both the orthosteric binding site (OBS) and a secondary binding pocket (
Externí odkaz:
https://doaj.org/article/c32595f0cebf4f86b145258df520dd63
Autor:
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sánchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104771- (2022)
Summary: Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets
Externí odkaz:
https://doaj.org/article/073b353a30d149d4b39ba15b63d8a932
Autor:
Emma S. Gogarnoiu, Caleb D. Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik, Omar Soler-Cedeño, Guo-Hua Bi, Benjamin Klein, Zheng-Xiong Xi, J. Robert Lane, Amy Hauck Newman
Publikováno v:
Journal of Medicinal Chemistry. 66:1809-1834
Autor:
R. Benjamin Free, Ashley N. Nilson, Noelia M. Boldizsar, Trevor B. Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W. Bertz, Jinbin Xu, Herman D. Lim, Andrés E. Dulcey, Robert H. Mach, James H. Woods, J Robert Lane, Lei Shi, Juan J. Marugan, William C. Wetsel, David R. Sibley
Publikováno v:
ACS Pharmacology & Translational Science. 6:151-170
Autor:
R. Benjamin Free, Ashley N. Nilson, Noelia M. Boldizsar, Trevor B. Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W. Bertz, Jinbin Xu, Herman D. Lim, Andrés E. Dulcey, Robert H. Mach, James H. Woods, J Robert Lane, Lei Shi, Juan J. Marugan, William C. Wetsel, David R. Sibley
We have developed and characterized a novel D2R antagonist with exceptional GPCR selectivity – ML321. In functional profiling screens of 168 different GPCRs, ML321 showed little activity beyond potent inhibition of the D2R, and to a lesser extent t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a0f9a844dff00ad9e58ab05b7c6477
https://doi.org/10.1101/2022.11.14.516475
https://doi.org/10.1101/2022.11.14.516475
Autor:
Joshua E. Allen, Stéphane A. Laporte, J. Robert Lane, David R. Sibley, Yoon Namkung, R. Benjamin Free, Blair K. A. Willette, Bing Xie, Marta Sánchez-Soto, Caroline A. Cuoco, Varun V. Prabhu, Lei Shi, Marilyn M. Day
Publikováno v:
Mol Pharmacol
ONC201 is a first-in-class imipridone compound that is in clinical trials for the treatment of high-grade gliomas and other advanced cancers. Recent studies identified that ONC201 antagonizes D2-like dopamine receptors at therapeutically relevant con
Autor:
Saheem A. Zaidi, Julie Sanchez, Meritxell Canals, Alessandro Bonifazi, Eric Bow, Mariia Makarova, Kenner C. Rice, Agnieszka Sulima, Jianjing Cao, Amy Hauck Newman, J. Robert Lane, Vsevolod Katritch, Anver Basha Shaik, Francisco O. Battiti
Publikováno v:
Journal of Medicinal Chemistry. 64:7778-7808
The need for safer pain-management therapies with decreased abuse liability inspired a novel drug design that retains μ-opioid receptor (MOR)-mediated analgesia, while minimizing addictive liability. We recently demonstrated that targeting the dopam
Autor:
Anika Mann, Hanka Mark, Alastair C. Keen, J. Robert Lane, Stefan Schulz, Pooja Dasgupta, Jonathan A. Javitch, Meritxell Canals
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
The dopamine D2 receptor (D2R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D2R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and interaction wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2797f88d9daed5cce550cb4cef0e26c