Zobrazeno 1 - 10
of 184
pro vyhledávání: '"J Robert Lane"'
Autor:
Darling, Arthur B.
Publikováno v:
The New England Quarterly, 1942 Jun 01. 15(2), 363-365.
Externí odkaz:
https://www.jstor.org/stable/360535
Autor:
Alastair C. Keen, Maria Hauge Pedersen, Laura Lemel, Daniel J. Scott, Meritxell Canals, Dene R. Littler, Travis Beddoe, Yuki Ono, Lei Shi, Asuka Inoue, Jonathan A. Javitch, J. Robert Lane
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
A recently identified pertussis toxin-like AB5 toxin, OZITX, is found to inhibit Gαi/o and Gαz G proteins. In combination with directed mutations, it is a useful tool for interrogating Gαi/o/z G protein subunits individually.
Externí odkaz:
https://doaj.org/article/ac065c0033244eb3932a5b3f91103777
Autor:
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sánchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104771- (2022)
Summary: Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to the stimulation of brain dopamine D2 receptors (D2R), bromocriptine also targets
Externí odkaz:
https://doaj.org/article/073b353a30d149d4b39ba15b63d8a932
Autor:
Anika Mann, Alastair C. Keen, Hanka Mark, Pooja Dasgupta, Jonathan A. Javitch, Meritxell Canals, Stefan Schulz, J. Robert Lane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The dopamine D2 receptor (D2R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D2R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and inter
Externí odkaz:
https://doaj.org/article/ca749480bcc9489bb045eb4ed1f42bf3
Publikováno v:
The American Historical Review, 1942 Oct 01. 48(1), 135-136.
Externí odkaz:
https://www.jstor.org/stable/1843304
Autor:
Emma S. Gogarnoiu, Caleb D. Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik, Omar Soler-Cedeño, Guo-Hua Bi, Benjamin Klein, Zheng-Xiong Xi, J. Robert Lane, Amy Hauck Newman
Publikováno v:
Journal of Medicinal Chemistry. 66:1809-1834
Autor:
R. Benjamin Free, Ashley N. Nilson, Noelia M. Boldizsar, Trevor B. Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov, Mayako Machino, Kuo Hao Lee, Jeremiah W. Bertz, Jinbin Xu, Herman D. Lim, Andrés E. Dulcey, Robert H. Mach, James H. Woods, J Robert Lane, Lei Shi, Juan J. Marugan, William C. Wetsel, David R. Sibley
Publikováno v:
ACS Pharmacology & Translational Science. 6:151-170
Autor:
J Robert Lane, Ara M Abramyan, Pramisha Adhikari, Alastair C Keen, Kuo-Hao Lee, Julie Sanchez, Ravi Kumar Verma, Herman D Lim, Hideaki Yano, Jonathan A Javitch, Lei Shi
Publikováno v:
eLife, Vol 9 (2020)
By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R/r
Externí odkaz:
https://doaj.org/article/22ae5702392642ec91760a357236acbd
Autor:
David A. Sykes, J. Robert Lane, Monika Szabo, Ben Capuano, Jonathan A. Javitch, Steven J. Charlton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-5 (2018)
Externí odkaz:
https://doaj.org/article/3b5818ff24944d2888354db7faccd2e3
Publikováno v:
Molecules, Vol 26, Iss 13, p 3799 (2021)
(1) Background: Two first-in-class racemic dopamine D1 receptor (D1R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D1R and reported lack of intri
Externí odkaz:
https://doaj.org/article/e41cae1eb0584987aadc02f3f867426a