Zobrazeno 1 - 10
of 2 305
pro vyhledávání: '"J Riese"'
Autor:
Emily P. Vonderhaar, Nicholas S. Barnekow, Donna McAllister, Laura McOlash, Mahmoud Abu Eid, Matthew J. Riese, Vera L. Tarakanova, Bryon D. Johnson, Michael B. Dwinell
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 41-58 (2021)
Background & Aims: Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor microenvironment renders patients resistant to emerging immune-targeted therapie
Externí odkaz:
https://doaj.org/article/040336860c1f40a1a33eef7faad56fe7
Autor:
Jason J. Luke, Sarina A. Piha-Paul, Theresa Medina, Claire F. Verschraegen, Mary Varterasian, Aoife M. Brennan, Richard J. Riese, Anna Sokolovska, James Strauss, David L. Hava, Filip Janku
Publikováno v:
Clinical Cancer Research. :OF1-OF10
Purpose: SYNB1891 is a live, modified strain of the probiotic Escherichia coli Nissle 1917 (EcN) engineered to produce cyclic dinucleotides under hypoxia, leading to STimulator of INterferon Genes (STING) activation in phagocytic antigen-presenting c
Autor:
Chao Yang, Jason R. Siebert, Robert Burns, Zachary J. Gerbec, Benedetta Bonacci, Amy Rymaszewski, Mary Rau, Matthew J. Riese, Sridhar Rao, Karen-Sue Carlson, John M. Routes, James W. Verbsky, Monica S. Thakar, Subramaniam Malarkannan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct trans
Externí odkaz:
https://doaj.org/article/c0d7b97edd22455d8504f80ccc09c6b8
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Chimeric antigen receptor (CAR) T-cell therapy is an emerging option for cancer treatment, but its efficacy is limited, especially in solid tumors. This is partly because the CAR T cells become dysfunctional and exhausted in the tumor micr
Externí odkaz:
https://doaj.org/article/46fdf68b933c4b81816f119845ff0132
Autor:
Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee, Matthew J. Riese
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells. A direct comparison of tumor growth between mice lacking each isoform has not been
Externí odkaz:
https://doaj.org/article/5d3031950b2e4b1aa8390e28fad5c75f
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Chemokines are a family of small, secreted cytokines which regulate a variety of cell functions. The C-X-C motif chemokine ligand 12 (CXCL12) binds to C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7). The interactio
Externí odkaz:
https://doaj.org/article/f60c44e2bb364899b1e7e1914b68f1d2
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101580- (2020)
Summary: Immunotherapy with monoclonal antibodies targeting immune checkpoint molecules, including programmed death-1 (PD-1), PD ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen (CTLA)-4, has become prominent in the treatment of many t
Externí odkaz:
https://doaj.org/article/8abed9206ec94d0a93eae1568c9fd57d
Autor:
Zachary J. Gerbec, Elaheh Hashemi, Arash Nanbakhsh, Sandra Holzhauer, Chao Yang, Ao Mei, Shirng-Wern Tsaih, Angela Lemke, Michael J. Flister, Matthew J. Riese, Monica S. Thakar, Subramaniam Malarkannan
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101454- (2020)
Summary: During an immune response, natural killer (NK) cells activate specific metabolic pathways to meet the increased energetic and biosynthetic demands associated with effector functions. Here, we found in vivo activation of NK cells during Liste
Externí odkaz:
https://doaj.org/article/9cfd2343a8df4691b8cafb60fbcdcdf6
Autor:
Chao Yang, Jason R Siebert, Robert Burns, Yongwei Zheng, Ao Mei, Benedetta Bonacci, Demin Wang, Raul A Urrutia, Matthew J Riese, Sridhar Rao, Karen-Sue Carlson, Monica S Thakar, Subramaniam Malarkannan
Publikováno v:
eLife, Vol 9 (2020)
The transcriptional activation and repression during NK cell ontology are poorly understood. Here, using single-cell RNA-sequencing, we reveal a novel role for T-bet in suppressing the immature gene signature during murine NK cell development. Based
Externí odkaz:
https://doaj.org/article/9738a645226d43e4b9f73828d7f1156b
Autor:
Richard L Cullum, Lauren M Lucas, Jared I Senfeld, John T Piazza, Logan T Neel, Kanupriya Whig, Ling Zhai, Mackenzie H Harris, Cristina C Rael, Darby C Taylor, Laura J Cook, David P Kaufmann, Christopher P Mill, Megan A Jacobi, Forrest T Smith, Mark Suto, Robert Bostwick, Ram B Gupta, Allan E David, David J Riese Ii
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243901 (2020)
Whereas recent clinical studies report metastatic melanoma survival rates high as 30-50%, many tumors remain nonresponsive or become resistant to current therapeutic strategies. Analyses of The Cancer Genome Atlas (TCGA) skin cutaneous melanoma (SKCM
Externí odkaz:
https://doaj.org/article/b577cffb2bf84042b2d2698e0a334423