Zobrazeno 1 - 10
of 188
pro vyhledávání: '"J Richard McIntosh"'
Autor:
Fabian Link, Alyssa Borges, Oliver Karo, Marvin Jungblut, Thomas Müller, Elisabeth Meyer-Natus, Timothy Krüger, Stefan Sachs, Nicola G Jones, Mary Morphew, Markus Sauer, Christian Stigloher, J Richard McIntosh, Markus Engstler
Publikováno v:
eLife, Vol 12 (2024)
Endocytosis is a common process observed in most eukaryotic cells, although its complexity varies among different organisms. In Trypanosoma brucei, the endocytic machinery is under special selective pressure because rapid membrane recycling is essent
Externí odkaz:
https://doaj.org/article/dfc612ce408442ef84c5ac553c298179
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253684 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0247022.].
Externí odkaz:
https://doaj.org/article/0fceea90db6e4bba88d8fc0344dcbc4e
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247022 (2021)
Electron cryo-microscopy (Cryo-EM) is a powerful method for visualizing biological objects with up to near-angstrom resolution. Instead of chemical fixation, the method relies on very rapid freezing to immobilize the sample. Under these conditions, c
Externí odkaz:
https://doaj.org/article/3dc8ba7e8b1343aa96e7ab2b9eeb2895
Autor:
Christopher Edelmaier, Adam R Lamson, Zachary R Gergely, Saad Ansari, Robert Blackwell, J Richard McIntosh, Matthew A Glaser, Meredith D Betterton
Publikováno v:
eLife, Vol 9 (2020)
The essential functions required for mitotic spindle assembly and chromosome biorientation and segregation are not fully understood, despite extensive study. To illuminate the combinations of ingredients most important to align and segregate chromoso
Externí odkaz:
https://doaj.org/article/1c6f5ff008554c72a077da7248d57908
Autor:
Johanna L Höög, Sylvain Lacomble, Eileen T O’Toole, Andreas Hoenger, J Richard McIntosh, Keith Gull
Publikováno v:
eLife, Vol 3 (2014)
Defects in flagella growth are related to a number of human diseases. Central to flagellar growth is the organization of microtubules that polymerize from basal bodies to form the axoneme, which consists of hundreds of proteins. Flagella exist in all
Externí odkaz:
https://doaj.org/article/2656d8ea2b064f589eedd9c45bfc0340
Autor:
Dmitrii S. Vinogradov, Evgeniy V. Ulyanov, J. Richard McIntosh, Fazoil I. Ataullakhanov, Nikita B. Gudimchuk
Publikováno v:
International Journal of Biomedicine, Vol 9, Iss Suppl_1, Pp S28-S29 (2019)
Background: Over the recent years, there has been a burst of ground-breaking studies, based on cryo-EM. They shed light on various intracellular structures, including microtubules (Alushin et al., 2014; Manka and Moores, 2018). Composed of 13 lateral
Externí odkaz:
https://doaj.org/article/de82ac539ee54141a88392863f474f66
Autor:
Zachary R. Gergely, Michele H. Jones, Bojun Zhou, Cai Cash, J. Richard McIntosh, Meredith D. Betterton
Publikováno v:
bioRxiv
Kinesin-5 motor proteins play essential roles during mitosis in most organisms. Their tetrameric structure and plus-end-directed motility allow them to bind to and move along antiparallel microtubules, thereby pushing spindle poles apart to assemble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d0f2c286a66ba084250d54a8284e42
https://europepmc.org/articles/PMC10187184/
https://europepmc.org/articles/PMC10187184/
Autor:
Nikita Gudimchuk, J. Richard McIntosh
Publikováno v:
Nature Reviews Molecular Cell Biology. 22:777-795
Microtubule dynamics and their control are essential for the normal function and division of all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic microtubule tips, which can bind to various intracellular targets, g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eac61920bcd10534d729c81792c424d
https://doi.org/10.1038/s41580-021-00399-x
https://doi.org/10.1038/s41580-021-00399-x
Autor:
Zachary R. Gergely, Saad Ansari, Michele H. Jones, J. Richard McIntosh, Meredith D. Betterton
Kinesin-5 motors are essential to separate mitotic spindle poles and assemble a bipolar spindle in many organisms. These tetrameric motors crosslink and slide apart antiparallel microtubules via microtubule plus-end-directed motility. However, kinesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52097f3b512d7cfc83c2a5ee8d8b8319
https://doi.org/10.1101/2022.08.01.502387
https://doi.org/10.1101/2022.08.01.502387
Autor:
Cynthia Page, Gabriella Li, J. Richard McIntosh, Ewa Szczesna, Eileen T. O'Toole, Dmitrii S. Vinogradov, Evgeni V. Ulyanov, Nikita Gudimchuk, Garry Morgan, Fazoil I. Ataullakhanov, Antonina Roll-Mecak, Jeffrey K. Moore
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Microtubules are dynamic tubulin polymers responsible for many cellular processes, including the capture and segregation of chromosomes during mitosis. In contrast to textbook models of tubulin self-assembly, we have recently demonstrated that microt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1154920086d0311a006ea386af7d25ba
http://link.springer.com/article/10.1038/s41467-020-17553-2
http://link.springer.com/article/10.1038/s41467-020-17553-2