Zobrazeno 1 - 10
of 54
pro vyhledávání: '"J Richard, Miller"'
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of thes
Externí odkaz:
https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be6
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Ghassan N. Fayad, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/15828ecf3c6a4e49a73581c4631d3a3d
Autor:
Philip E. Brandish, An Chi, Lily Y. Moy, Yanlin Jia, Andrey Loboda, Dongyu Sun, J. Richard Miller, Mangeng Cheng, Patrick J. Curran, Xuelei S. Song, Marc A. Sze, Peter Georgiev, Roshi Afshar, Amanda A. Watkins, Huijun Wang, Chunsheng Zhang, Josephine Hai, Carlo P. Ramil, Handan Xiang
Supplementary table 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64656741c70927de5a233d76a454565
https://doi.org/10.1158/2326-6066.22542700
https://doi.org/10.1158/2326-6066.22542700
Autor:
Philip E. Brandish, An Chi, Lily Y. Moy, Yanlin Jia, Andrey Loboda, Dongyu Sun, J. Richard Miller, Mangeng Cheng, Patrick J. Curran, Xuelei S. Song, Marc A. Sze, Peter Georgiev, Roshi Afshar, Amanda A. Watkins, Huijun Wang, Chunsheng Zhang, Josephine Hai, Carlo P. Ramil, Handan Xiang
Supplementary Figures 1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2bc9743ef2b2a28ab72dafb8d84c5a
https://doi.org/10.1158/2326-6066.22542706
https://doi.org/10.1158/2326-6066.22542706
Autor:
Philip E. Brandish, An Chi, Lily Y. Moy, Yanlin Jia, Andrey Loboda, Dongyu Sun, J. Richard Miller, Mangeng Cheng, Patrick J. Curran, Xuelei S. Song, Marc A. Sze, Peter Georgiev, Roshi Afshar, Amanda A. Watkins, Huijun Wang, Chunsheng Zhang, Josephine Hai, Carlo P. Ramil, Handan Xiang
Cancer-associated fibroblasts (CAF) represent a functionally heterogeneous population of activated fibroblasts that constitutes a major component of tumor stroma. Although CAFs have been shown to promote tumor growth and mediate resistance to chemoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236c7cea304c51ecf0cbb57fb91d0ac1
https://doi.org/10.1158/2326-6066.c.6550021.v1
https://doi.org/10.1158/2326-6066.c.6550021.v1
Autor:
Philip E. Brandish, An Chi, Lily Y. Moy, Yanlin Jia, Andrey Loboda, Dongyu Sun, J. Richard Miller, Mangeng Cheng, Patrick J. Curran, Xuelei S. Song, Marc A. Sze, Peter Georgiev, Roshi Afshar, Amanda A. Watkins, Huijun Wang, Chunsheng Zhang, Josephine Hai, Carlo P. Ramil, Handan Xiang
Supplementary table 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86caf6a403271b7da8e5c28cef29efaa
https://doi.org/10.1158/2326-6066.22542688.v1
https://doi.org/10.1158/2326-6066.22542688.v1
Autor:
Anandan Palani, Matthew Lloyd Childers, Qinglin Pu, Matthew J. Mitcheltree, Symon Gathiaka, Christian Fischer, Lisa Nogle, Rachel L. Palte, Jared N. Cumming, J. Richard Miller, Spencer McMinn, Hai-Young Kim, Hongjun Zhang, Charles A. Lesburg, Adam Beard, Donovon A. Adpressa, Josep Saurí, Derun Li, Theodore A. Martinot, Thomas W. Lyons, David L. Sloman, Jialiang Wang, Peter Spacciapoli, Min Lu, Abdelghani Achab
Publikováno v:
ACS Med Chem Lett
[Image: see text] Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cγ-exo conformation of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a3f9279f9db6a241567d164d50d64
https://doi.org/10.1021/acsmedchemlett.1c00258
https://doi.org/10.1021/acsmedchemlett.1c00258
Autor:
Symon Gathiaka, Rachel L. Palte, Sung-Sau So, Xiaomei Chai, J. Richard Miller, Reshma Kuvelkar, Xiujuan Wen, Steven Cifelli, Anthony Kreamer, Andy Liaw, David G. McLaren, Christian Fischer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 84:129193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c378db3e1bdb5153da20aabe9eb4d7c5
https://doi.org/10.1016/j.bmcl.2023.129193
https://doi.org/10.1016/j.bmcl.2023.129193
Autor:
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou, Meredeth A. McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Xavier Fradera, Charles A. Lesburg, Theodore A. Martinot, Ji Qi, Zhiguo J. Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne DAddio, Nicolas Solban, J. Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65de888aa90fb7088ca022d5b5ddf12
https://pubmed.ncbi.nlm.nih.gov/35239336
https://pubmed.ncbi.nlm.nih.gov/35239336
Autor:
Mangeng Cheng, Huijun Wang, Josephine Hai, Amanda A. Watkins, Andrey Loboda, Patrick J. Curran, An Chi, Chunsheng Zhang, Roshi Afshar, Xuelei S. Song, Marc A. Sze, Handan Xiang, J. Richard Miller, Dongyu Sun, Peter Georgiev, Yanlin Jia, Carlo P. Ramil, Lily Y. Moy, Philip E. Brandish
Publikováno v:
Cancer Immunology Research. 8:436-450
Cancer-associated fibroblasts (CAF) represent a functionally heterogeneous population of activated fibroblasts that constitutes a major component of tumor stroma. Although CAFs have been shown to promote tumor growth and mediate resistance to chemoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0dde9758f3373facfcea77cac7491c1
https://doi.org/10.1158/2326-6066.cir-19-0507
https://doi.org/10.1158/2326-6066.cir-19-0507