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Autor:
S. Fonseca, D. Hoton, S. Dardenne, L. Annet, C. Hubert, S. Godecharles, A. Jouret-Mourin, R. Reding, J. B. Otte, J. Rahier, J. F. Gigot, C. Sempoux
Publikováno v:
International Journal of Hepatology, Vol 2013 (2013)
Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1α-inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β-catenin-activated HCA (b-HCA). We reviewed retrospectively our surgical HCA series t
Externí odkaz:
https://doaj.org/article/380d6c7ff9f040078ae25430f8e15e3b
Autor:
Nicolas J. Rahier, Mangesh Jiotode, Rahul R. Lavhale, François Sautel, Arun Balakrishnan, Abhijeet S. Kate, Shilpa Amit Verekar, Sunil K. Deshmukh, Yannick Aussagues, Prafull Ranadive, Pradipta Tokdar, Céline Robichon, Arnaud Samson, Bruno Gomes, Samuel Meignan, Christian Bailly, Nicolas Molinier, Christophe Long
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3712-3721
A screening program aimed at discovering novel anticancer agents based on natural products led to the selection of koningic acid (KA), known as a potent inhibitor of glycolysis. A method was set up to produce this fungal sesquiterpene lactone in larg
Autor:
D Leonard, F Penninckx, A Kartheuser, A Laenen, E Van Eycken, C Bertrand, D De Coninck, M Duinslaeger, J Van de Stadt, W Vaneerdeweg, D Claeys, D Burnon, K Haustermans, P Scalliet, P Spaas, P Demetter, A Jouret-Mourin, C Sempoux, W Demey, Y Humblet, E Van Cutsem, S Laurent, J L Van Laethem, B Op de Beeck, P Smeets, M Melange, J Rahier, M Cabooter, P Pattyn, M Peeters, M Buset, B Mansvelt, K Vindevoghel, M Daubie, A Thijs
Publikováno v:
The British journal of surgery, Vol. 101, no. 11, p. 1475-82 (2014)
Background Research on the relationship between hospital volume and quality of care in the treatment of rectal cancer is limited. Methods Process and outcome indicators were assessed in patients with rectal adenocarcinoma who underwent total mesorect
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2011, 17 (44), pp.12276-12279. ⟨10.1002/chem.201101195⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2011, 17 (44), pp.12276-12279. ⟨10.1002/chem.201101195⟩
International audience; Mild & green: The commercially and readily available PNPCl behaves as a very effective catalyst for the synthesis of various trimethylsilyl cyanohydrins from a wide range of aliphatic, cyclic, α,β-unsaturated and aromatic ke
Publikováno v:
Tetrahedron. 64:6645-6650
A study of the reactivity of Ph3P NLi towards phosphorus electrophiles allowed us to develop a general method to isolate, or cleanly generate in situ, a broad family of polyphosphinimines displaying P N–P bonds. A preliminary application of this me
Blackness in the Andes : Ethnographic Vignettes of Cultural Politics in the Time of Multiculturalism
Autor:
J. Rahier
This book examines, in Andean national contexts, the impacts of the'Latin American multicultural turn'of the past two decades on Afro Andean cultural politics, emphasizing both transformations and continuities.
Autor:
Yi Zhang, Sidney M. Hecht, Ambar Kumar Choudhury, Rong Gao, Nicolas J. Rahier, Larisa M. Dedkova
Publikováno v:
Biochemistry. 45:8402-8410
The human topoisomerase I-mediated DNA relaxation reaction was studied following modification of the enzyme at the active site tyrosine (position 723). A series of unnatural tyrosine analogues was incorporated into the active site of human topoisomer
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:1381-1386
A recent X-ray crystallographic analysis of the binding of a water soluble camptothecin analogue to the human topoisomerase I-DNA covalent binary complex has suggested the existence of some novel features in the way that camptothecin is bound to the
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:1585-1604
This review provides a detailed discussion of recent advances in the medicinal chemistry of camptothecin, a potent antitumor antibiotic. Two camptothecin analogues are presently approved for use in the clinic as antitumor agents and several others ar