Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J Rafael Ciges-Tomas"'
Autor:
Roberto Gozalbo-Rovira, J Rafael Ciges-Tomas, Susana Vila-Vicent, Javier Buesa, Cristina Santiso-Bellón, Vicente Monedero, María J Yebra, Alberto Marina, Jesús Rodríguez-Díaz
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007865 (2019)
Rotavirus is the leading agent causing acute gastroenteritis in young children, with the P[8] genotype accounting for more than 80% of infections in humans. The molecular bases for binding of the VP8* domain from P[8] VP4 spike protein to its cellula
Externí odkaz:
https://doaj.org/article/c176d7d4520d41a4a1161293ab313219
Autor:
Jorge Donderis, Janine Bowring, Elisa Maiques, J Rafael Ciges-Tomas, Christian Alite, Iltyar Mehmedov, María Angeles Tormo-Mas, José R Penadés, Alberto Marina
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006581 (2017)
The dUTPase (Dut) enzymes, encoded by almost all free-living organisms and some viruses, prevent the misincorporation of uracil into DNA. We previously proposed that trimeric Duts are regulatory proteins involved in different cellular processes; incl
Externí odkaz:
https://doaj.org/article/b685be69f65e4ca19b93269a06841113
Autor:
Janine Bowring, Maan M Neamah, Jorge Donderis, Ignacio Mir-Sanchis, Christian Alite, J Rafael Ciges-Tomas, Elisa Maiques, Iltyar Medmedov, Alberto Marina, José R Penadés
Publikováno v:
eLife, Vol 6 (2017)
Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, the clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread in nature. SaPIs reside passively in the host c
Externí odkaz:
https://doaj.org/article/84a722f134d4403092f7b86bf3b7ca97
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
The molecular basis of GTP binding to the N protein from SARS-CoV-2 is presented, providing a framework for drug design and disruption of the RNA packing function in the N protein.
Externí odkaz:
https://doaj.org/article/7f5a7bf449c348c795b2128f07b32812
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Stl, the master repressor of the Staphylococcus aureus pathogenicity islands (SaPIs), targets phage-encoded proteins to derepress and synchronize the SaPI and the helper phage life cycles. To activate their cycle, some SaPI Stls target both
Externí odkaz:
https://doaj.org/article/60c9cda5c2a44f358c3cb9422d2d1a47
Autor:
Rafael Molina, Ricardo Garcia-Martin, Blanca López-Méndez, Anne Louise Grøn Jensen, J Rafael Ciges-Tomas, Javier Marchena-Hurtado, Stefano Stella, Guillermo Montoya
Publikováno v:
Molina, R, Garcia-Martin, R, López-Méndez, B, Jensen, A L G, Ciges-Tomas, J R, Marchena-Hurtado, J, Stella, S & Montoya, G 2022, ' Molecular basis of cyclic tetra-oligoadenylate processing by small standalone CRISPR-Cas ring nucleases ', Nucleic Acids Research, vol. 50, no. 19, pp. 11199-11213 . https://doi.org/10.1093/nar/gkac923
15 pags., 7 figs., 1 tab.
Standalone ring nucleases are CRISPR ancillary proteins, which downregulate the immune response of Type III CRISPR-Cas systems by cleaving cyclic oligoadenylates (cA) second messengers. Two genes with this function have
Standalone ring nucleases are CRISPR ancillary proteins, which downregulate the immune response of Type III CRISPR-Cas systems by cleaving cyclic oligoadenylates (cA) second messengers. Two genes with this function have
Autor:
Suzanne Humphrey, Janine Bowring, José R. Penadés, Christian Alite, Xavier Salvatella, Jorge Donderis, Alberto Marina, J. Rafael Ciges-Tomas
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
16 páginas, 7 figuras, 2 tablas. Coordinates and structure factors have been deposited in the Protein Data Bank under accession code 6H48, 6H4B, 6H49, 6H4C.
Stl is a master repressor encoded by Staphylococcus aureus pathogenicity islands (SaPIs
Stl is a master repressor encoded by Staphylococcus aureus pathogenicity islands (SaPIs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb3de05c6780204fc6ce4d577088478
http://hdl.handle.net/10044/1/80422
http://hdl.handle.net/10044/1/80422
Autor:
Jorge Donderis, J. Rafael Ciges-Tomas, Elisa Maiques, Suzanne Humphrey, Christian Alite, José R. Penadés, Alberto Marina
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
12 páginas, 5 figuras, 3 tablas
The trimeric staphylococcal phage-encoded dUTPases (Duts) are signalling molecules that induce the cycle of some Staphylococcal pathogenicity islands (SaPIs) by binding to the SaPI-encoded Stl repressor. To perfo
The trimeric staphylococcal phage-encoded dUTPases (Duts) are signalling molecules that induce the cycle of some Staphylococcal pathogenicity islands (SaPIs) by binding to the SaPI-encoded Stl repressor. To perfo
Autor:
Janine Bowring, Maan M Neamah, Christian Alite, Iltyar Medmedov, José R. Penadés, Elisa Maiques, Alberto Marina, Ignacio Mir-Sanchis, J. Rafael Ciges-Tomas, Jorge Donderis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c261356070247d1004883fe74f6af695
https://doi.org/10.7554/elife.26487.034
https://doi.org/10.7554/elife.26487.034
Autor:
Janine Bowring, Elisa Maiques, J. Rafael Ciges-Tomas, Alberto Marina, Jorge Donderis, Iltyar Mehmedov, Christian Alite, José R. Penadés, María Ángeles Tormo-Más
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 9, p e1006581 (2017)
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
PLOS Pathogens
PLOS PATHOGENS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 9, p e1006581 (2017)
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
PLOS Pathogens
PLOS PATHOGENS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
24 páginas, 6 figuras, 3 tablas
The dUTPase (Dut) enzymes, encoded by almost all free-living organisms and some viruses, prevent the misincorporation of uracil into DNA. We previously proposed that trimeric Duts are regulatory proteins involved
The dUTPase (Dut) enzymes, encoded by almost all free-living organisms and some viruses, prevent the misincorporation of uracil into DNA. We previously proposed that trimeric Duts are regulatory proteins involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79aa4e75796451328762673c08b56719
http://hdl.handle.net/10261/156457
http://hdl.handle.net/10261/156457