Antimicrobial Activity of Murine Lung Cells against Staphylococcus aureus Is Increased In Vitro and In Vivo after Elafin Gene Transfer

Autor: K. Hayashi, K. J. Taylor, J. M. Sallenave, William Wallace, J. W. Mcmichael, Julia R. Dorin, Alison Maxwell, J. R. W. Govan

Publikováno v: Mcmichael, J W, Maxwell, A I, Hayashi, K, Taylor, K, Wallace, W, Govan, J R, Dorin, J R & Sallenave, J 2005, ' Antimicrobial Activity of Murine Lung Cells against Staphylococcus aureus Is Increased In Vitro and In Vivo after Elafin Gene Transfer ', Infection and Immunity, vol. 73, no. 6, pp. 3609-3617 . https://doi.org/10.1128/IAI.73.6.3609-3617.2005

Staphylococcus aureus is a pathogen often found in pneumonia and sepsis. In the context of the resistance of this organism to conventional antibiotics, an understanding of the regulation of natural endogenous antimicrobial molecules is of paramount i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6da7f47cdb2710d9d6c11e18491eed9
https://doi.org/10.1128/iai.73.6.3609-3617.2005

A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis

Autor: M E Hodson, J R W Govan, C G Gallagher

Publikováno v: European Respiratory Journal. 20:658-664

Chronic infection with Pseudomonas aeruginosa is associated with progressive deterioration in lung function in cystic fibrosis (CF) patients. The purpose of this trial was to assess the efficacy and safety of tobramycin nebuliser solution (TNS) and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1366288440665a89b935bcba54bf866a
https://doi.org/10.1183/09031936.02.00248102

Elafin (elastase-specific inhibitor) has anti-microbial activity against Gram-positive and Gram-negative respiratory pathogens

Autor: A.J. Simpson, Christopher Haslett, A.I. Maxwell, J. R. W. Govan, Jean-Michel Sallenave

Publikováno v: FEBS Letters. 452:309-313

Elafin (elastase-specific inhibitor) is a low molecular weight inhibitor of neutrophil elastase which is secreted in the lung. Using synthetic peptides corresponding to full-length elafin (H2N-1AVT.....95Q-OH), the NH2-terminal domain (H2N-1AVT.....5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d388351ad188df1816a87a3d1238fcb4
https://doi.org/10.1016/s0014-5793(99)00670-5

Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection

Autor: J P, Clancy, L, Dupont, M W, Konstan, J, Billings, S, Fustik, C H, Goss, J, Lymp, P, Minic, A L, Quittner, R C, Rubenstein, K R, Young, L, Saiman, J L, Burns, J R W, Govan, B, Ramsey, R, Gupta, Catherine, Doherty

Publikováno v: Thorax
Clancy, J P, Dupont, L, Konstan, M W, Billings, J, Fustik, S, Goss, C H, Lymp, J, Minic, P, Quittner, A L, Rubenstein, R C, Young, K R, Saiman, L, Burns, J L, Govan, J R W, Ramsey, B, Gupta, R 2013, ' Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection ', Thorax, vol. 68, no. 9, pp. 818-25 . https://doi.org/10.1136/thoraxjnl-2012-202230

Rationale Arikace is a liposomal amikacin preparation for aerosol delivery with potent Pseudomonas aeruginosa killing and prolonged lung deposition.Objectives To examine the safety and efficacy of 28 days of once-daily Arikace in cystic fibrosis (CF)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c95aa8bf4e95d4f420299008c02c591
https://pubmed.ncbi.nlm.nih.gov/23749840

Multi-resistance isolates possessing characteristics of both Burkholderia (Pseudomonas) cepacia and Burkholderia gladioli from patients with cystic fibrosis

Autor: J. W. Nelson, Sarah L. Butler, I. N. Simpson, D. J. Winstanley, N. Dewhurst, J. R. W. Govan, J. Finlay

Publikováno v: Journal of Antimicrobial Chemotherapy. 34:353-361

Multi-resistant strains from three UK centres, previously identified as Burkholderia (formerly Pseudomonas) cepacia, and associated with morbidity, mortality and transmission among patients with cystic fibrosis have been further characterised. Bioche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0b69cb2a47b9a926b9e730f9c6e5d8
https://doi.org/10.1093/jac/34.3.353