Výsledky vyhledávání

Induction of expression of the cystic fibrosis transmembrane conductance regulator

Autor: N Kartner, J R Riordan, William Breuer, Z I Cabantchik

Publikováno v: Journal of Biological Chemistry. 267:10465-10469

The cystic fibrosis transmembrane conductance regulator (CFTR) was studied in HT-29 human colonic carcinoma cells with the aim of assessing possible mechanisms of up-regulation of its expression. CFTR was identified and quantified in total cell extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::693c78178e2ef070cf7b4a91aca2d74d
https://doi.org/10.1016/s0021-9258(19)50041-2

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cAMP-binding proteins in epithelial cells cultured from human sweat glands

Autor: J. R. Riordan, D. J. Pon, M. Wong, B. P. Schimmer

Publikováno v: American Journal of Physiology-Cell Physiology. 258:C1036-C1043

This study characterized the various adenosine 3',5'-cyclic monophosphate (cAMP)-binding proteins in epithelial cells cultured from human sweat glands to identify potential pathways of cAMP action in this tissue. The cAMP-binding proteins were identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef6da9ac6ad793a0f2a813328be4bda
https://doi.org/10.1152/ajpcell.1990.258.6.c1036

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Multiple flavonoid-binding sites within multidrug resistance protein MRP1

Autor: Xiu Bao Chang, Doriane Trompier, J. R. Riordan, Denis Barron, Hélène Baubichon-Cortay, A. Di Pietro, Mathias Maitrejean

Publikováno v: Cellular and molecular life sciences : CMLS. 60(10)

Recombinant nucleotide-binding domains (NBDs) from human multidrug resistance protein MRP1 were overexpressed in bacteria and purified to measure their direct interaction with high-affinity flavonoids, and to evaluate a potential correlation with inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6456a6cb67eec76b2f5d49a0174ca9ca
https://pubmed.ncbi.nlm.nih.gov/14618263

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A novel CFTR disease-associated mutation causes addition of an extra N-linked oligosaccharide

Autor: M M, Hämmerle, A A, Aleksandrov, X B, Chang, J R, Riordan

Publikováno v: Glycoconjugate journal. 17(11)

We have examined the influence of a novel missense mutation in the fourth extracytoplasmic loop (EL4) of CFTR detected in a patient with cystic fibrosis. This substitution (T908N) creates a consensus sequence (N X S/T) for addition of an N-linked oli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef25c74580be764c6a6638bcdd0b0a7c
https://pubmed.ncbi.nlm.nih.gov/11443282

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Traffic pattern of cystic fibrosis transmembrane regulator through the early exocytic pathway

Autor: S I, Bannykh, G I, Bannykh, K N, Fish, B D, Moyer, J R, Riordan, W E, Balch

Publikováno v: Traffic (Copenhagen, Denmark). 1(11)

The pathway of transport of the cystic fibrosis transmembrane regulator (CFTR) through the early exocytic pathway has not been examined. In contrast to most membrane proteins that are concentrated during export from the ER and therefore readily detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b03b96ccd39a8fc011033805110692fe
https://pubmed.ncbi.nlm.nih.gov/11208075

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Etiology of CF: knowns and unknowns

Autor: J R, Riordan

Publikováno v: Pediatric pulmonology. Supplement. 18

It is still difficult to rationalize many of the features of CF with mutations in a single gene coding for a protein with one well-established function. The central question to be resolved is whether there are additional functions of CFTR to be disco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09a333003f2ec68547b9df7b8f2bb1bd
https://pubmed.ncbi.nlm.nih.gov/10093110

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Therapeutic strategies for treatment of CF based on knowledge of CFTR

Autor: J R, Riordan

Publikováno v: Pediatric pulmonology. Supplement. 18

CF is one of the first diseases where it is now possible to take an entirely "bottom-up" approach and attempt to develop molecular therapeutics based on fundamental properties of the gene and gene product which cause the disease. As I have tried to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::223215fa6dc139e467f12dd07e660d97
https://pubmed.ncbi.nlm.nih.gov/10093106

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The Myelin-Deficient Rat Has a Single Base Substitution in the Third Exon of the Myelin Proteolipid Protein Gene

Autor: J. R. Riordan, R. Simons

Publikováno v: Journal of Neurochemistry. 54:1079-1081

Several genetic disorders that occur in animals and in humans result in an inability to synthesize normal myelin. Some of these disorders are inherited in an X-linked manner. The localization of the myelin proteolipid protein (PLP) gene to the X chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a0437a03d830c7d964a834b970b23e
https://doi.org/10.1111/j.1471-4159.1990.tb02360.x

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