Výsledky vyhledávání

Methanodibenzosuberylpiperazines as potent multidrug resistance reversal agents

Autor: N. Zutshi, P. Cheung, J. R. Pfister, Helen Y. Wu, D. L. Slate, J. T. Nelson, F. Makra, S. M. Casey, N. A. Bruno, A. V. Muehldorf

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2473-2476

Annellation of a cyclopropyl group to the dibenzosuberane moiety of the prototypical agent MS-073 afforded potent multiple drug resistance modulators. The chiral differentiation observed for the enantiomers of some of these compounds points to a spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::755967e6b0d4b3d643388b96aa75967d
https://doi.org/10.1016/0960-894x(95)00426-t

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ChemInform Abstract: Methanodibenzosuberylpiperazines as Potent Multidrug Resistance Reversal Agents

Autor: N. A. Bruno, S. M. Casey, P. Cheung, N. Zutshi, A. V. Muehldorf, J. R. Pfister, F. Makra, J. T. Nelson, Helen Y. Wu, D. L. Slate

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83482aa4cef3cb4736d48478a61a4d75
https://doi.org/10.1002/chin.199609165

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Improving estimates of HIV-1 seroprevalence among childbearing women: use of smaller blood spots

Autor: J R Pfister, Jeffrey P. Davis, N J Hoxie, P A Markwardt-Elmer, G L Hoffman, J M Vergeront

Publikováno v: American Journal of Public Health. 82:1370-1373

OBJECTIVES. Nationwide, human immunodeficiency virus type 1 (HIV-1) seroprevalence surveys using dried neonatal blood specimens are critical to estimating HIV-1 seroprevalence among childbearing women. However, the noninclusion of blood specimens dee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc734bfea3788fdc56b141e5a0808a0
https://doi.org/10.2105/ajph.82.10.1370

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RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for functional alpha 1-adrenoceptors in human prostate: implications for adrenoceptor classification

Autor: A P, Ford, N F, Arredondo, D R, Blue, D W, Bonhaus, J, Jasper, M S, Kava, J, Lesnick, J R, Pfister, I A, Shieh, R L, Vimont, T J, Williams, J E, McNeal, T A, Stamey, D E, Clarke

Publikováno v: Molecular pharmacology. 49(2)

Norepinephrine (NE) contracts smooth muscle cells within the human lower urinary tract (LUT) (bladder neck, prostate, and urethra). Receptor distribution and pharmacological evidence have implicated activation of alpha 1A-adrenoceptors. We disclose t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b09f58bc6d85af082442d4f38b513af3
https://pubmed.ncbi.nlm.nih.gov/8632751

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RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance

Autor: D L, Slate, N A, Bruno, S M, Casey, N, Zutshi, L J, Garvin, H, Wu, J R, Pfister

Publikováno v: Anticancer research. 15(3)

A novel multidrug resistance modulator, RS-33295-198, circumvented drug resistance in human, mouse, and Chinese hamster cell lines overexpressing P-glycoprotein. It enhanced the antiproliferative activity of doxorubicin, vincristine, etoposide, and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70d6af6daa099c5c72215eded26becd5
https://pubmed.ncbi.nlm.nih.gov/7645963

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The action of (+/-)L-660,863 [(+/-)3-(3-amino-1,2,4-oxadiazole-5-yl)-quinuclidine] at muscarinic receptor subtypes in vitro

Autor: E. H. F. Wong, A. P. D. W. Ford, Richard M. Eglen, Roger L. Whiting, G.C. Harris, J. R. Pfister

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 345(4)

1. The muscarinic pharmacology of a novel oxadiazole muscarinic agonist, (+/-) L-660,863, [+/-3-(3-amino-1,2,4-oxadiazole-5-yl)-quinuclidine] has been studied using pharmacological, radioligand binding and biochemical techniques, in vitro. 2. In isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd3bf206d94df14d5d0189613104753
https://pubmed.ncbi.nlm.nih.gov/1620240

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Characterization of muscarinic receptors mediating release of epithelial derived relaxant factor (EpDRF) in guinea-pig isolated trachea

Autor: M. Taylor, R. L. Whiting, G.C. Harris, J. R. Pfister, Richard M. Eglen

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 344(1)

Muscarinic receptors mediating the release of epithelial derived relaxant factor (EpDRF) have been studied by using both contractions of the guinea-pig tracheal strip (with epithelium intact or denuded) or a coaxial bioassay assembly (rat anococcygeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0afacfbea35187d33911918f5032363
https://pubmed.ncbi.nlm.nih.gov/1775190

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HIV-1 among childbearing women and newborns in Wisconsin

Autor: N J, Hoxie, J M, Vergeront, J R, Pfister, G, Hoffman, P A, Markwardt, J P, Davis

Publikováno v: Wisconsin medical journal. 89(11)

To estimate the prevalence of antibody to human immunodeficiency virus-type 1 (HIV-1) among Wisconsin childbearing women (CBW), a continuous blinded HIV-1 seroprevalence survey is being conducted. This survey uses dried blood specimens obtained from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9cb1ca38e521a3111e2ef9b9bdb6d94
https://pubmed.ncbi.nlm.nih.gov/2136199

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