Zobrazeno 1 - 10
of 24
pro vyhledávání: '"J R Lepock"'
Autor:
J. R. Lepock, G. A. Senisterra
Publikováno v:
International Journal of Hyperthermia. 16:1-17
Local anaesthetics, in addition to anaesthesia, induce the synthesis of heat shock proteins (HSPs), sensitize cells to hyperthermia, and increase the aggregation of nuclear proteins during heat shock. Anaesthetics are membrane active agents, and anae
Publikováno v:
Journal of Biological Chemistry. 265:21612-21618
The conformational stability and reversibility of unfolding of the human dimeric enzyme Cu Zn superoxide dismutase (HSOD) and the three mutant enzymes constructed by replacement of Cys6 by Ala and Cys111 by Ser, singly and in combination, were determ
Publikováno v:
Cell stresschaperones. 6(2)
Heat shock sensitizes cells to ionizing radiation, cells heated in S phase have increased chromosomal aberrations, and both Hsp27 and Hsp70 translocate to the nucleus following heat shock, suggesting that the nucleus is a site of thermal damage. We s
Autor:
M J, Borrelli, D M, Stafford, C M, Rausch, L J, Bernock, M L, Freeman, J R, Lepock, P M, Corry
Publikováno v:
Journal of cellular physiology. 177(3)
Treatment with the sulfhydryl oxidant diamide denatures and aggregates cellular proteins, which prior studies have implicated as an oxidative damage that activates the heat shock transcription factor and induces thermotolerance. This study was initia
Autor:
A T, McDuffee, G, Senisterra, S, Huntley, J R, Lepock, K R, Sekhar, M J, Meredith, M J, Borrelli, J D, Morrow, M L, Freeman
Publikováno v:
Journal of cellular physiology. 171(2)
While oxidative stress can induce a heat shock response, the primary signals that initiate activation have not been identified. To identify such signals, HepG2 and V 79 cells were exposed to menadione, a compound that redox-cycles to generate superox
Publikováno v:
The Journal of the Royal Astronomical Society of Canada. Royal Astronomical Society of Canada. 90(4)
We have carried out a series of calculations involving bacteria and viruses embedded in dust grains, which are ejected from our solar system by radiation pressure and travel through space to other star systems. Under many conditions this type of pans
Publikováno v:
Journal of cellular physiology. 167(3)
An excellent correlation has been established between the quantity of protein associated with nuclei isolated from heat-shocked cells and the level of hyperthermic cell killing. However, controversy remains about whether increases in nuclear-associat
Autor:
J, Kruuv, J R, Lepock
Publikováno v:
Cryobiology. 32(2)
The Arrhenius plot of inactivation (killing) rates of V-79 Chinese hamster cells exposed to hypothermia in air-equilibrated (aerobic) medium contains a break at about 8 degrees C, which corresponds to the minimum inactivation rate, implying that ther
Publikováno v:
Radiation research. 131(2)
Hyperthermia increases levels of nuclear-associated proteins in a manner that correlates with cell killing. If the increase in nuclear-associated proteins represents a lethal lesion then treatments that protect against killing by heat should reduce a
Autor:
K H, Cheng, J R, Lepock
Publikováno v:
Biochemistry. 31(16)
Calcium uptake by rabbit skeletal sarcoplasmic reticulum (SR) is inhibited with an effective inactivation temperature (TI) of 37 degrees C in EGTA with no effect on ATPase activity. Since the Ca-ATPase denatures at a much higher temperature (49 degre