Zobrazeno 1 - 5
of 5
pro vyhledávání: '"J R Keddie"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 48:601-606
4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM 241385) is currently the most selective for the A2a adenosine receptor antagonist. This paper describes the in-vivo activity of ZM 241385 after administration by
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:138-139
We have previously shown that 8-phenyltheophylline (8-PT), a non-selective antagonist at adenosine A1-and A2-receptors, has a diuretic effect. In this study, the diuretic and adenosine antagonist effects of the A1-receptor selective compound 1,3-dipr
Autor:
S T, Kau, B B, Howe, J H, Li, L H, Smith, J R, Keddie, J J, Barlow, R E, Giles, M E, Goldberg
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 242(3)
ICI 147,798 is a novel compound which has both diuretic and beta adrenoceptor blocking properties in a single molecule. The natriuretic activity at 30 mg/kg p.o. was about 65% of the hydrochlorothiazide value at 10 mg/kg p.o. in saline-loaded rats; t
Autor:
M. G. Collis, J. R. Keddie
Publikováno v:
Clinical science (London, England : 1979). 61(3)
1. Angiotensin-converting enzyme inhibitors can attenuate reflex sympathetic vasoconstriction in vivo. We have investigated the effects of captopril (SQ 14 225) on adrenergic vasoconstrictor mechanisms in isolated, Krebs-Ringer solution perfused, rat
Publikováno v:
The Journal of pharmacy and pharmacology. 38(11)
The diuretic and adenosine antagonist actions of two alkylxanthines have been compared in the conscious rat. 8-Phenyltheophylline (10 mg kg−1) antagonized adenosine-induced bradycardia in the rat for at least 3 h whereas enprofylline (10 mg kg−1)