Zobrazeno 1 - 10
of 29
pro vyhledávání: '"J R Gum"'
Publikováno v:
Annals of Oncology. 10:S51-S55
Mucins are high molecular weight glycoproteins which are heavily glycosylated with many carbohydrate side chains. In epithelial cancers such as biliopancreatic cancer, both quantitative and qualitative alterations in carbohydrate and polypeptide moie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b48990f20cc401dea53ebc1235886a4
https://doi.org/10.1093/annonc/10.suppl_4.s51
https://doi.org/10.1093/annonc/10.suppl_4.s51
Autor:
J. R. Gum
Publikováno v:
Biochemical Society Transactions. 23:795-799
It has been clear for some time now that mucin glycoproteins have extensive, highly glycosylated tandem repeat domains. What is becoming increasingly apparent, however, is the diversity of unique sequences present on different mucins. Variations in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508ad090ff0dbfe03ed1c6b336c92f57
https://doi.org/10.1042/bst0230795
https://doi.org/10.1042/bst0230795
Autor:
J R, Gum, J W, Hicks, A M, Gillespie, J L, Rius, P A, Treseler, S C, Kogan, E J, Carlson, C J, Epstein, Y S, Kim
Publikováno v:
Cancer research. 61(8)
Mucinous colorectal cancers exhibit a characteristic set of molecular genetic alterations and may be derived from progenitor cells committed to the goblet cell lineage. Previously, we demonstrated that the MUC2 mucin gene promoter drives transgene re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb62bae742e15b12a7fb5027759d71b4
https://pubmed.ncbi.nlm.nih.gov/11309310
https://pubmed.ncbi.nlm.nih.gov/11309310
Autor:
D M, Swallow, L E, Vinall, J R, Gum, Y S, Kim, H, Yang, J I, Rotter, M, Mirza, J C, Lee, J E, Lennard-Jones
Publikováno v:
Journal of medical genetics. 36(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2f9b2ddb5ac63fa1a94894ee3343a9f
https://pubmed.ncbi.nlm.nih.gov/10636731
https://pubmed.ncbi.nlm.nih.gov/10636731
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 10
Mucins are high molecular weight glycoproteins which are heavily glycosylated with many carbohydrate side chains. In epithelial cancers such as biliopancreatic cancer, both quantitative and qualitative alterations in carbohydrate and polypeptide moie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2eedbabca8267ba754ee730149b6fd3a
https://pubmed.ncbi.nlm.nih.gov/10436785
https://pubmed.ncbi.nlm.nih.gov/10436785
Publikováno v:
The Biochemical journal. 338
Hepatocyte nuclear factor 1 was identified as the transcription factor binding to a 20 bp (-150 to -131) region of the gene for human dipeptidyl peptidase IV, which has been shown to be important for the expression of dipeptidyl peptidase IV in the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb4fe9e90195386bf025b37a5745b755
https://pubmed.ncbi.nlm.nih.gov/9931303
https://pubmed.ncbi.nlm.nih.gov/9931303
Autor:
J R, Gum, J J, Ho, W S, Pratt, J W, Hicks, A S, Hill, L E, Vinall, A M, Roberton, D M, Swallow, Y S, Kim
Publikováno v:
The Journal of biological chemistry. 272(42)
MUC3 is a large mucin glycoprotein expressed by the human intestine and gall bladder. In this manuscript, we present details of the deduced protein structure of MUC3. The MUC3 carboxyl-terminal domain is 617 residues in length, including 511 residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df1b404b70dae18d5de5d5b745750da3
https://pubmed.ncbi.nlm.nih.gov/9334251
https://pubmed.ncbi.nlm.nih.gov/9334251
Publikováno v:
The Journal of biological chemistry. 272(26)
The distribution of MUC6 suggests that its primary function is protection of vulnerable epithelial surfaces from damaging effects of constant exposure to a wide range of endogenous caustic or proteolytic agents. A combination of genomic, cDNA. and 3'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc5106d382d08bc748ce3ac0a8f5aa07
https://pubmed.ncbi.nlm.nih.gov/9195947
https://pubmed.ncbi.nlm.nih.gov/9195947
Publikováno v:
The Journal of biological chemistry. 269(27)
To obtain cDNAs for analysis of mucin gene transcription in rat models of human disease, we screened a rat intestinal cDNA library in lambda ZAPII using an upstream non-tandem repeat cDNA fragment of the human MUC 2 gene (Gum, J., Hicks, J., Toribara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::476ccf24cce30aba4d5a8525a50d4af1
https://pubmed.ncbi.nlm.nih.gov/8027037
https://pubmed.ncbi.nlm.nih.gov/8027037
Publikováno v:
The Journal of biological chemistry. 269(4)
Secretory mucins consist of a protein backbone that is catenated by disulfide bonds, heavily O-glycosylated, and packaged into storage granules prior to release from cells. In this paper, we identify and sequence cDNAs that encode the amino terminus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c23d45b7398dda66402e228b5b98d915
https://pubmed.ncbi.nlm.nih.gov/8300571
https://pubmed.ncbi.nlm.nih.gov/8300571