Zobrazeno 1 - 10
of 43
pro vyhledávání: '"J R Gamble"'
Publikováno v:
The Journal of Immunology. 157:360-368
A central mechanism of inflammation is the activation of vascular endothelium by the inflammatory cytokines TNF-alpha and IL-1. These cytokines induce the expression of adhesion molecules, the elaboration of chemokines, and the transendothelial migra
Autor:
Peter Vandenabeele, X. Van Ostade, W B Smith, J. Barbara, J R Gamble, Walter Fiers, Angel F. Lopez, M A Vadas, Jan Tavernier
Publikováno v:
The EMBO Journal. 13:843-850
Human tumour necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine capable of killing mammalian tumour cells in vitro and in vivo, and of enhancing the proinflammatory activity of leucocytes and endothelium, the latter effects limiting its usag
Publikováno v:
The Journal of Immunology. 150:4494-4503
Transforming growth factor-beta (TGF-beta), a pleiotropic cytokine that is elaborated in the active form upon co-culture of endothelial cells and pericytes or smooth muscle cells, has been shown to decrease the adhesiveness of endothelial cells for n
Autor:
J R Gamble, M A Vadas
Publikováno v:
The Journal of Immunology. 146:1149-1154
Recombinant human transforming growth factor-beta (TGF-beta) was found to inhibit the adhesive phenotype of human umbilical vein endothelial cells for human PBL, purified T lymphocytes, and PHA-activated lymphoblasts. TGF-beta inhibited lymphocyte at
Autor:
Michele A. Grimbaldeston, C. Brand, J. Drew, Prue H. Hart, John J. Finlay-Jones, J. R. Gamble
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 51(5)
Objective: To examine the anti-inflammatory activities of tea tree oil (TTO) in vivo.¶Methods: Mice were sensitized to a chemical hapten, trinitrochlorobenzene, on their ventral skin and 7 days later challenged (or re-exposed) on their dorsal skin w
Publikováno v:
Journal of lipid research. 41(8)
The ability of different phosphatidylcholine (PC) species to inhibit cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) was investigated. PC species containing palmitoyl- in th
Autor:
S M, Pitson, P A, Moretti, J R, Zebol, P, Xia, J R, Gamble, M A, Vadas, R J, D'Andrea, B W, Wattenberg
Publikováno v:
The Journal of biological chemistry. 275(43)
Sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a lipid messenger that plays an important role in a variety of mammalian cell processes, including inhibition of apoptosis and stimulation of cell proliferation. Basal
Publikováno v:
The Journal of biological chemistry. 274(46)
The ability of high density lipoproteins (HDL) to inhibit cytokine-induced adhesion molecule expression has been demonstrated in their protective function against the development of atherosclerosis and associated coronary heart disease. A key event i
Publikováno v:
Journal of lipid research. 40(2)
Previous studies have shown that both high density lipoproteins (HDL) isolated from human plasma and reconstituted HDL (rHDL) are effective inhibitors of adhesion molecule expression in human endothelial cells. In this study rHDL have been used to in
Publikováno v:
The Journal of biological chemistry. 273(43)
Stimulation of platelet aggregation leads to tyrosine phosphorylation of a number of receptors and signaling molecules including platelet endothelial cell adhesion molecule-1 (PECAM-1). In this report, we demonstrate that both protein-tyrosine phosph