Primary Sequence and Three-Dimensional Structural Comparison between Malanin and Ricin, a Type II Ribosome-Inactivating Protein

Autor: Yan Yuan, Shuxiao Wu, Philip J. R. Day

Publikováno v: Toxins, Vol 16, Iss 10, p 440 (2024)

Malanin is a new type II ribosome-inactivating protein (RIP) purified from Malania oleifera, a rare, endangered tree is only found in the southwest of Guangxi Province and the southeast of Yunnan Province, China. The gene coding sequence of malanin w

Externí odkaz: https://doaj.org/article/44eb97d4150b4082986e64d33f09ba1d

Directed evolution of an efficient and thermostable PET depolymerase

Autor: Elizabeth L. Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, Saranarayanan Ramachandran, Aleksander A. Tedstone, Sarah J. Haigh, Arthur A. Garforth, Philip J. R. Day, Colin Levy, Michael P. Shaver, Anthony P. Green

Publikováno v: Nature Catalysis. 5:673-681

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7e1d2020fa56daaf4656cb9e083de41
https://doi.org/10.1038/s41929-022-00821-3

An Analysis of Mechanisms for Cellular Uptake of miRNAs to Enhance Drug Delivery and Efficacy in Cancer Chemoresistance

Autor: Justine M. Grixti, Duncan Ayers, Philip J. R. Day

Publikováno v: Non-Coding RNA, Vol 7, Iss 2, p 27 (2021)

Up until recently, it was believed that pharmaceutical drugs and their metabolites enter into the cell to gain access to their targets via simple diffusion across the hydrophobic lipid cellular membrane, at a rate which is based on their lipophilicit

Externí odkaz: https://doaj.org/article/de98bfd6af994a5590e9cee6cad80f20

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

Autor: Maria Ababi, Nicholas J. Turner, Elizabeth L. Bell, Neil Swainston, Joanna C. Sadler, Andrew Currin, Philip J. R. Day, Jane Kwok, Douglas B. Kell

Publikováno v: ACS Synthetic Biology
Currin, A, Kwok, J, Sadler, J C, Bell, E L, Swainston, N, Ababi, M, Day, P, Turner, N J & Kell, D B 2019, ' GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries ', ACS Synthetic Biology, vol. 8, no. 6, pp. 1371-1378 . https://doi.org/10.1021/acssynbio.9b00063
Currin, A, Kwok, J, Sadler, J C, Bell, E L, Swainston, N, Ababi, M, Day, P, Turner, N J & Kell, D B 2019, ' GeneORator : An effective strategy for navigating protein sequence space more efficiently through boolean or-type DNA libraries ', ACS Synthetic Biology, vol. 8, no. 6, pp. 1371-1378 . https://doi.org/10.1021/acssynbio.9b00063

Directed evolution requires the creation of genetic diversity and subsequent screening or selection for improved variants. For DNA mutagenesis, conventional site-directed methods implicitly utilize the Boolean AND operator (creating all mutations sim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4318a47b131fa45b42bb0a47b1e4b5fb
https://doi.org/10.1021/acssynbio.9b00063

Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas.

Autor: Guangping Tai, Parisa Ranjzad, Fiona Marriage, Samrina Rehman, Helen Denley, Jill Dixon, Karen Mitchell, Philip J R Day, Adrian S Woolf

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81167 (2013)

The mammalian ureter contains a water-tight epithelium surrounded by smooth muscle. Key molecules have been defined which regulate ureteric bud initiation and drive the differentiation of ureteric mesenchyme into peristaltic smooth muscle. Less is kn

Externí odkaz: https://doaj.org/article/a0d40cf4e89a4fbcb1b5e4e04b56ccf5