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Lipoprotein profile characterization of the KKA(y) mouse, a rodent model of type II diabetes, before and after treatment with the insulin-sensitizing agent pioglitazone

Autor: J R Colca, C K Castle, G W Melchior

Publikováno v: Arteriosclerosis and thrombosis : a journal of vascular biology. 13(2)

The purpose of this study was to characterize the lipoprotein profile in the KKA(y) mouse, a rodent model of type II diabetes, before and after treatment with the insulin-sensitizing drug pioglitazone. Analysis of the plasma from untreated KKA(y) mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3909121d4488c9b794c45dc4fca96c
https://pubmed.ncbi.nlm.nih.gov/8427865

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Calcium and the malaria parasite: parasite maturation and the loss of red cell deformability

Autor: D J, Krogstad, S P, Sutera, J S, Marvel, I Y, Gluzman, C W, Boylan, J R, Colca, J R, Williamson, P H, Schlesinger

Publikováno v: Blood cells. 17(1)

In the studies reported here, we examined the role of calcium in the maturation of the human malaria parasite Plasmodium falciparum, and in the loss of red cell deformability associated with parasite maturation. P. falciparum alters the permeability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb219609947061b6ef211a619c0fa7fc
https://pubmed.ncbi.nlm.nih.gov/1902127

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Effects of insulin secretagogues on protein kinase C-catalyzed phosphorylation of an endogenous substrate in isolated pancreatic islets

Autor: R A, Easom, M, Landt, J R, Colca, J H, Hughes, J, Turk, M, McDaniel

Publikováno v: The Journal of biological chemistry. 265(25)

The influence of the insulin secretagogues, carbachol and glucose, on protein kinase C activation in isolated pancreatic islets has been examined by determination of the phosphorylation state of an endogenous 80-kDa protein substrate of protein kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1851e9d98e79f0830dfdc1f80f5fab8f
https://pubmed.ncbi.nlm.nih.gov/2203765

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Arachidonic acid metabolism in isolated pancreatic islets. I. Identification and quantitation of lipoxygenase and cyclooxygenase products

Autor: J, Turk, J R, Colca, N, Kotagal, M L, McDaniel

Publikováno v: Biochimica et biophysica acta. 794(1)

The metabolism of arachidonic acid by pancreatic islets has been studied with purified populations of large numbers of islets isolated from the rat. Sequential high-performance liquid chromatographic analyses of islet-derived metabolites of 3H-labele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e62e59b5239784f8dbdfb98f3eeb233
https://pubmed.ncbi.nlm.nih.gov/6329307

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Alloxan inhibition of a Ca2+- and calmodulin-dependent protein kinase activity in pancreatic islets

Autor: J R, Colca, N, Kotagal, C L, Brooks, P E, Lacy, M, Landt, M L, McDaniel

Publikováno v: The Journal of biological chemistry. 258(12)

Alloxan was found to inhibit a Ca2+- and calmodulin-dependent protein kinase recently identified in pancreatic islets. This effect of alloxan may be specifically related to the inhibitory action of alloxan on insulin secretion from islets since: 1) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a451f61620f7cca3ea9e9ee00da3563
https://pubmed.ncbi.nlm.nih.gov/6345520

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Active calcium uptake by islet-cell endoplasmic reticulum

Autor: J R, Colca, J M, McDonald, N, Kotagal, C, Patke, C J, Fink, M H, Greider, P E, Lacy, M L, McDaniel

Publikováno v: The Journal of biological chemistry. 257(12)

Active calcium uptake was demonstrated in a subcellular fraction of islets which was enriched in endoplasmic reticulum. Calcium uptake was stimulated by ATP in a magnesium-dependent manner. The rate of calcium accumulation was sustained by oxalate (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db49ecea5e8a87b55832aa651110e547
https://pubmed.ncbi.nlm.nih.gov/6806268

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A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans

Autor: M L, McDaniel, J R, Colca, N, Kotagal, P E, Lacy

Publikováno v: Methods in enzymology. 98

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fa1ba1a7af83097284f3635146d69d7
https://pubmed.ncbi.nlm.nih.gov/6366468

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Regulation of calcium uptake/efflux from the islet-cell endoplasmic reticulum with regard to the secretion of insulin

Autor: J R, Colca, B A, Wolf, M L, McDaniel

Publikováno v: Progress in clinical and biological research. 265

Figure 8 summarizes some of the processes that may impact on the secretion of insulin by regulating Ca2+ handling by the beta-cell endoplasmic reticulum. A role for calmodulin in controlling the rate of Ca2+ efflux is indicated by both the ability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8531e91282d78bec107ad67c0add096
https://pubmed.ncbi.nlm.nih.gov/3043440

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