Zobrazeno 1 - 10 of 30 pro vyhledávání: '"J R, Thornback"'
1
The detection and quantitation of inflammation in the central nervous system during experimental allergic encephalomyelitis using the radiopharmaceutical 99mTc-RP128
Autor: Carolyn Paul, Christopher Bolton, Susan H. Peers, Anne Goodbody, J. R. Thornback, Lesley E. Woodhouse
Publikováno v: Journal of Neuroscience Methods. 98:83-90
RP128 is a novel agent which readily chelates 99mTc to form a radiopharmaceutical which binds in vivo to the tuftsin receptor located specifically on neutrophils and monocyte-macrophages, therefore removing the need for in vitro cell labelling prior
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f0a914bbc3206af70644888fe85ddd
https://doi.org/10.1016/s0165-0270(00)00201-6
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3
Darstellung und Charakterisierung von [N-(2-Mercaptoacetyl)-N? -4-(penten-3on-2)ethylen-1,2-diaminato]oxorhenium(V), ReO(MRP 40)
Autor: R. Wollert, J. R. Thornback, Ulrich Abram, M. Deblaton, Joachim Stach, Sonja Abram, G. F. Morgan
Publikováno v: Zeitschrift f�r anorganische und allgemeine Chemie. 600:15-19
Der Titelkomplex entsteht in guten Ausbeuten bei der Umsetzung von (Bu4N)ReOBr4 oder ReOCl3(Ph3P)2 mit der triphenylmethyl-geschutzten Form des vierzahnigen Liganden. Die Struktur des Chelats als neutrale Oxoverbindung des Rheniums (V) wird durch ana
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ac7b0912747b57787335fa14e8094d5
https://doi.org/10.1002/zaac.19916000103
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5
Biodistribution and dosimetry of (99m)Tc-RP527, a gastrin-releasing peptide (GRP) agonist for the visualization of GRP receptor-expressing malignancies
Autor: C, Van de Wiele, F, Dumont, R A, Dierckx, S H, Peers, J R, Thornback, G, Slegers, H, Thierens
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 42(11)
The aim of this study was to determine the human biodistribution and radiation dosimetry of (99m)Tc-RP527, a promising radioligand for the visualization of gastrin-releasing peptide (GRP) receptor-expressing human malignancies.Whole-body scans were o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0cc5cf50188ce9e5ddb5877ddceee280
https://pubmed.ncbi.nlm.nih.gov/11696645
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6
Evaluation of 99mTc-RP128 as a potential inflammation imaging agent: human dosimetry and first clinical results
Autor: V, Caveliers, A E, Goodbody, L L, Tran, S H, Peers, J R, Thornback, A, Bossuyt
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 42(1)
99mTc-RP128 is a bifunctional peptide chelate designed to target the tuftsin receptor, expressed by neutrophils, monocytes, and macrophages. Studies in animal models of both infectious and noninfectious inflammation have shown a positive correlation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5d707d404bcad355291e230f6a560d4
https://pubmed.ncbi.nlm.nih.gov/11197967
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7
Differences in the intracellular processing of the radiolabel following the uptake of iodine-125- and technetium-99m-neogalactosyl albumin by the isolated perfused rat liver
Autor: S, Gore, A I, Morris, I T, Gilmore, P J, Maltby, J R, Thornback, D, Billington
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 32(3)
Neogalactosyl albumin (NGA) is a synthetic ligand to the asialoglycoprotein receptor (hepatic binding protein), which has been proposed as a useful receptor binding radiopharmaceutical for the noninvasive assessment of liver function. We have compare
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f49e32e1d736398ebe95ea7f940723e7
https://pubmed.ncbi.nlm.nih.gov/2005461
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8
Technetium-99m-MRP20, a potential brain perfusion agent: in vivo biodistribution and SPECT studies in normal male volunteers
Autor: A, Bossuyt, G F, Morgan, M, offlaton, R, Pirotte, A, Chirico, P, Clemens, P, Vandenbroeck, J R, Thornback
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 32(3)
The lipophilic neutral complex [99mTc][TcO(MRP20)] [MRP20 is (N-(2(1H pyrolylmethyl]N'-(4-pentene-3-one-2)ethane-1,2-diamine)] is known to cross the blood-brain barrier in non-primate animals. We report here its in vivo biodistribution, radiation dos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7304c0dac9ec5593eb20dfe012c86122
https://pubmed.ncbi.nlm.nih.gov/2005447
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9
Technetium-99m-MRP20, a potential brain perfusion agent: in vivo biodistribution and SPECT studies in non-primate animals
Autor: G F, Morgan, M, Deblaton, P, Clemens, P, Van Den Broeck, A, Bossuyt, J R, Thornback
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 32(3)
MRP20 (N-(2(1H pyrolylmethyl]N'-(4-pentene-3-one-2] ethane-1,2-diamine) complexes with technetium-99m, yielding a neutral, lipophilic species. This compound has been characterized as [TcO(MRP20)]. Biologic investigation of [99mTc][TcO(MRP20)] in fema
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1213fa1675f50c829a54bbdc3a7ed9f7
https://pubmed.ncbi.nlm.nih.gov/2005460
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