Zobrazeno 1 - 10
of 25
pro vyhledávání: '"J R, Sanes"'
Autor:
J R, Sanes, J W, Lichtman
Publikováno v:
Nature Reviews Neuroscience. 2:791-805
The prefrontal cortex has a vital role in effective, organized behaviour. Both functional neuroimaging in humans and electrophysiology in awake monkeys indicate that a fundamental principle of prefrontal function might be adaptive neural coding — i
Autor:
P T, Martin, J R, Sanes
Publikováno v:
Development. 124:3909-3917
Agrin, a basal lamina-associated proteoglycan, is a crucial nerve-derived organizer of postsynaptic differentiation at the skeletal neuromuscular junction. Because integrins serve as cellular receptors for many basal lamina components, we asked wheth
Publikováno v:
Histochemistry. 95:513-517
We used the histochemical stain for ATPase to compare the fiber-type composition of rat internal and external intercostal muscles from thoracic (T) segments 2-5, 8, and 11. At each level, type II fibers were more numerous than type I fibers, type II
Publikováno v:
Cell Regulation. 1:731-740
The distribution of subunits of the basement membrane proteins laminin and merosin in human and rabbit tissue was studied by immunofluorescence using monoclonal antibodies. The laminin A chain is present in epithelial, endothelial, and smooth muscle
Publikováno v:
Neuron. 31(3)
In developing muscle, synapse elimination reduces the number of motor axons that innervate each postsynaptic cell. This loss of connections is thought to be a consequence of axon branch trimming. However, branch retraction has not been observed direc
Autor:
T M, Jessell, J R, Sanes
Publikováno v:
Current opinion in neurobiology. 10(5)
Our understanding of neural development has advanced dramatically over the past decade. Significant insights have now been obtained into seven fundamental developmental processes: first, induction of the neural plate; second, regionalization of the n
Publikováno v:
Neuron. 25(2)
The dystrophin-glycoprotein complex (DGC) links the cytoskeleton of muscle fibers to their extracellular matrix. Using knockout mice, we show that a cytoplasmic DGC component, alpha-dystrobrevin (alpha-DB), is dispensable for formation of the neuromu
Publikováno v:
The European journal of neuroscience. 11(10)
Motoneurons reinnervating skeletal muscles form nerve terminals at sites of contact with a specialized basal lamina. To analyse the molecules and mechanisms that underly these responses, we introduce two systems in which basal lamina-derived componen
Publikováno v:
Neuron. 23(1)
Agrin induces synaptic differentiation at the skeletal neuromuscular junction (NMJ); both pre- and postsynaptic differentiation are drastically impaired in its absence. Multiple alternatively spliced forms of agrin that differ in binding characterist
Publikováno v:
Journal of neurobiology. 37(3)
Laminin is a major component of all basement membranes. However, its composition varies with location because there are numerous forms of each of the three chains (alpha, beta, and gamma) that together comprise this heterotrimeric molecule. In the ne