Zobrazeno 1 - 10
of 10
pro vyhledávání: '"J R, Pauly"'
Publikováno v:
Brain Research. 771:89-103
Both human essential hypertension and genetically induced hypertension in rats have been associated with a range of impairments of cognitive ability. The spontaneous hypertensive rat (SHR) previously has been shown to exhibit a decrease in the expres
Publikováno v:
Medical science monitor : international medical journal of experimental and clinical research. 7(6)
Exposure to nicotine has been shown to promote neuronal survival after excitotoxic insult to the brain. The role of specific nicotinic acetylcholine receptors (nAChRs) subtypes in mediating this effect is not well understood, however. Examination of
Publikováno v:
The European journal of neuroscience. 13(1)
To assess the role of nicotinic cholinergic receptors (nAChR) on neuronal maturation, nAChR expression and the direct effects of nAChR activation were examined in cerebellar external granular layer (EGL) precursors isolated in vitro. Treatment of EGL
Publikováno v:
The Journal of comparative neurology. 423(4)
Acetylcholine allows the elicitation of visually evoked behaviors mediated by the frog optic tectum, but the mechanisms behind its effects are unknown. Although nicotinic acetylcholine receptors (nAChRs) exist in the tectum, their subtype has not bee
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(1)
It has recently been shown using regionally dissected tissue that both chronic mecamylamine treatment and chronic nicotine treatment increase the number of [3H]-nicotine binding sites in mouse brain, and that additive increases in the number of bindi
Autor:
D J, Anderson, M, Williams, J R, Pauly, J L, Raszkiewicz, J E, Campbell, G, Rotert, B, Surber, S B, Thomas, J, Wasicak, S P, Arneric
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(3)
ABT-418 [(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole] is a potent and selective agonist at neuronal nicotinic acetylcholine receptors (nAChRs) with cognitive enhancing and anxiolytic activities. [3H]ABT-418 was found to bind with high affinity
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 258(3)
Quantitative autoradiographic procedures were used to examine the effects of chronic nicotine infusion on the number of central nervous system nicotinic cholinergic receptors. Female DBA mice were implanted with jugular cannulas and infused with sali
Publikováno v:
Ciba Foundation symposium. 152
Although numerous studies have demonstrated that chronic nicotine treatment often results in tolerance to this drug, the mechanisms that underlie this tolerance are not well defined. Recent evidence suggests that chronic nicotine treatment results in
Publikováno v:
Behavioural Pharmacology. 6:632
Publikováno v:
Journal of substance abuse. 1(3)
Studies of smoking behavior in human twin pairs indicate that genetic factors may influence whether people do, or do not, smoke. Because the ability to develop tolerance to behavioral and physiological effects of nicotine may regulate nicotine intake