Zobrazeno 1 - 10
of 15
pro vyhledávání: '"J R, McCarrey"'
Publikováno v:
Biology of reproduction. 64(5)
In mice, transplantation of spermatogonial stem cells from a fertile male to the seminiferous tubules of an infertile recipient male results in progeny with donor-derived haplotype. Attempts to extend this approach by transplanting human testis cells
Publikováno v:
Biology of reproduction. 64(5)
The DNA in eukaryotic cells is organized into loop domains that are 25 to 100 kilobases long and attached at their bases to the nuclear matrix. This organization plays major roles in DNA replication and transcription. We examined changes in DNA loop
Publikováno v:
Molecular reproduction and development. 56
The first tier of control over the expression of genic domains utilizes chromatin structure. Before the onset of transcription, the chromatin domain that encompasses the gene(s) must assume an open conformation. This renders large segments of the gen
Publikováno v:
Journal of andrology. 20(5)
We have constructed a series of 23 cDNA libraries from mouse and rat testicular cells. These include libraries made from whole, intact adult testes; seminiferous tubule cells from adult testes; combined populations of primary spermatocytes from 18-da
Publikováno v:
Biology of reproduction. 60(6)
The PGK2 gene is expressed in a strictly tissue-specific manner in meiotic spermatocytes and postmeiotic spermatids during spermatogenesis in eutherian mammals. Previous results indicate that this is regulated at the transcriptional level by core pro
Publikováno v:
Biology of reproduction. 59(2)
Transcription of the autosomal phosphoglycerate kinase gene, Pgk-2, is initiated at the onset of meiosis during spermatogenesis in mammals. However, in the mouse, the 5' portion of the endogenous Pgk-2 coding sequence undergoes a specific demethylati
Autor:
D, Kamel, Z B, Mackey, T, Sjöblom, C A, Walter, J R, McCarrey, L, Uitto, H, Palosaari, J, Lähdetie, A E, Tomkinson, J E, Syväoja
Publikováno v:
Biology of reproduction. 57(6)
Previous studies on DNA polymerase epsilon indicate that this enzyme is involved in replication of chromosomal DNA. In this study, we examined the expression of DNA polymerases alpha, delta, and epsilon during mouse testis development and germ cell d
Publikováno v:
Biology of reproduction. 55(3)
XRCC1 is involved in DNA strand-break repair, homologous recombination, and sister chromatid exchange and is expressed as a low-abundance mRNA with elevated expression in testis. The purpose of this study was to determine whether specific spermatogen
Publikováno v:
Developmental genetics. 19(4)
Because of their unique function, germ cells require unique gene products. Thus, although the glycolytic enzyme phosphoglycerate kinase (PGK) is required in all metabolically active cell types, there are two functional PGK genes in the mammalian geno
Publikováno v:
Biology of reproduction. 48(3)
We have constructed cDNA libraries representing transcripts from purified populations of germ cells and of somatic cells, isolated from fetal mouse gonads at 12.5 days postcoitum (dpc). We have used these libraries to study differential gene expressi