Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011

Autor: F. Aigbirhio, M. V. C. L. Appleyard, R. L. Arrowsmith, S. A. Baldwin, M. Bayrakdarian, N. P. Botting, L. D. Cantin, D. R. Carbery, M. A. Carroll, L. I. Dixon, P. N. Dorff, G. Ellames, C. S. Elmore, C. W. G. Fishwick, O. Foot, N. J. Geach, J. Gowdy, R. S. Grainger, T. Gregson, W. R. R. Harker, P. J. F. Henderson, J. R. Heys, S. W. Homans, Z. Hu, S. Jackson, J. Johnston, P. Johnson, A. Kalverda, C. Kay, S. L. Kitson, B. Lanoue, M. H. Levitt, Y. Li, W. J. S. Lockley, X Luo, P. Ma, D. A. Middleton, J. Newsome, B. Pandya, S. I. Pascu, S. G. Patching, M. K. Phillips-Jones, M. E. Powell, P. Riss, J. Simmons, T. M. Simpson, A. D. Smith, A. M. Thompson, L. Trembleau, R. Turtle, K. W. Watters, Q. Zhang

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 55:125-134

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6ab254fd151b5f93096303a436d3de
https://doi.org/10.1002/jlcr.2907

16th International Isotope Society (UK group) Symposium

Autor: G. Åberg, F. I. Aigbirhio, E. Alexakis, N. Al-Maharik, M. Almi, Y. Ambacher, S. Andersson, A. Athlan, G. Badman, S. A. Baldwin, M. Baumann, I. R. Baxendale, N. P. Botting, R. A. Bragg, J. A. Brown, A. Burton, N. Bushby, K. Cable, G. Campbell, R. Carr, M. Carroll, L. Chen, M. Christlieb, P. Davies, G. J. Ellames, W. Ellis, C. Elmore, T. Fryatt, N. Geach, J. R. Harding, S. Hartmann, S. Harwood, J. J. Hayward, P. J. F. Henderson, R. B. Herbert, J. R. Heys, S. Hölzl, M. D. Hopkin, P. Horn, T. Ilyas, S. Irvine, S. D. Jackson, J. Jin, A. Keats, A. R. Kennedy, W. J. Kerr, M. O. Kitching, C. Landreau, S. Lanners, R. Lawrence, K. W. M. Lawrie, S. V. Ley, G. Little, W. J. S. Lockley, D. Maier, C. Manning, A. McNeill, D. A. Middleton, S. Montgomery, J. J. Morrison, L. Mrzljak, J. Newman, J. Newsome, N. Nikbin-Roudsari, G. N. Nilsson, M. F. Oldfield, S. G. Patching, D. J. Procter, G. Randall, A. A. Robertson, C. S. Rummel, D. Rustidge, R. Sherhod, N. Shipley, C. D. Smith, C. J. Smith, D. I. Smith, C. Song, L. Tamborini, I. Waterhouse, A. Watts, J. L. Werkheiser, G. Williams, C. L. Willis, P. Woodward, R. Yan, G. Young, Q. Zhang

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 51:247-261

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf6260af171d3f38543b97311ba343f4
https://doi.org/10.1002/jlcr.1513

A novel synthesis of [O-methyl-14C]dextromethorphan: utility of the vinyloxycarbonyl group

Autor: S. G. Senderoff, S.W. Landvatter, J. R. Heys

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 43:1283-1288

A novel, selective approach to [O-methyl-14C]Dextromethorphan is presented. The key feature is protection of 3-hydroxymorphinan at nitrogen and oxygen with the vinyloxycarbonyl group. This allows selective O-deprotection and methylation without compe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55d262172a4d0bf4bfe1537d85411429
https://doi.org/10.1002/1099-1344(200011)43:13<1283::aid-jlcr417>3.0.co

The novel synthesis of the protease inhibitor (S)-1-chloro-3-[(p-tolylsulfonyl)amino]-7-amino-2-[5,5,6,6-3H]heptanone ([3H]TLCK) labeled to high specific activity with tritium

Autor: J. R. Heys, A. J. Villani

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 39:379-386

The protease inhibitor (S)-1-chloro-3-[(p-tolylsulfonyl)amino]-7-amino-2-[5,5,6,6-3H]heptanone ([ 3 H]TLCK) was prepared in an overall 41% radiochemical yield with a specific activity of 1.6 Ci/mmol in a'one-pot' 3 step sequence beginning with (S)-6-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::710a5b0e65425cec3f3764b1c660e630
https://doi.org/10.1002/(sici)1099-1344(199705)39:5<379::aid-jlcr981>3.0.co

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Autor: J. R. Heys, S. W. Landvatter, Joseph C. Lee, James E. Strickler, George P. Livi, Jerry L. Adams, Dean E. McNulty, Jeffrey T. Laydon, Sanjay Kumar, John R. White, I. R. Siemens, Timothy Gallagher, M. J. Blumenthal, David W. Green, Peter Young, Peter C. McDonnell, Megan M. McLaughlin, Seth M. Fisher

Publikováno v: Nature. 372:739-746

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24d7b582bf7042b4595ca6a9251e1cd
https://doi.org/10.1038/372739a0