Zobrazeno 1 - 10
of 37
pro vyhledávání: '"J R, Halpert"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(9)
4-Vinyl-1-cyclohexene (VCH) is ovotoxic in B6C3F(1) mice but not in Fischer-344 rats, which can be partially attributed to greater formation of toxic epoxides from VCH in mice compared with rats. Since repeated exposure to VCH is necessary to cause o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::038fe9056278f6b97326c858f7503767
https://pubmed.ncbi.nlm.nih.gov/11502734
https://pubmed.ncbi.nlm.nih.gov/11502734
Autor:
R, Eiselt, T L, Domanski, A, Zibat, R, Mueller, E, Presecan-Siedel, E, Hustert, U M, Zanger, J, Brockmoller, H P, Klenk, U A, Meyer, K K, Khan, Y A, He, J R, Halpert, L, Wojnowski
Publikováno v:
Pharmacogenetics. 11(5)
The genetic component of the inter-individual variability in CYP3A4 activity has been estimated to be between 60% and 90%, but the underlying genetic factors remain largely unknown. A study of 213 Middle and Western European DNA samples resulted in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cc33a50114409bfc7348f584479dd7a
https://pubmed.ncbi.nlm.nih.gov/11470997
https://pubmed.ncbi.nlm.nih.gov/11470997
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(2)
The structural basis of cooperativity of progesterone hydroxylation catalyzed by human cytochrome P450 3A4 has been investigated. A recent study suggested that substitution of larger side chains at positions Leu-211 and Asp-214 partially mimics the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12e27366b3bbab4a2544431c488855b8
https://pubmed.ncbi.nlm.nih.gov/10773032
https://pubmed.ncbi.nlm.nih.gov/10773032
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
The structural basis for functional differences between human cytochrome P-450 2B6 and rat 2B1 was investigated. An amino acid sequence alignment predicted the location of 2B6 substrate recognition site (SRS) residues. Ten residues within these SRSs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd08ae80ec3e3b280791bf055005ae9d
https://pubmed.ncbi.nlm.nih.gov/10454488
https://pubmed.ncbi.nlm.nih.gov/10454488
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
RPR 106541 (20R-16alpha,17alpha-[butylidenebis(oxy)]-6al pha, 9alpha-difluoro-11beta-hydroxy-17beta-(methylthio)androst a-4-en-3-one) is an airway-selective steroid developed for the treatment of asthma. Two metabolites produced by human liver micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74ec7f75a156550876c58b95f8fa7bd2
https://pubmed.ncbi.nlm.nih.gov/10411567
https://pubmed.ncbi.nlm.nih.gov/10411567
Autor:
S M, Strobel, G D, Szklarz, Y, He, M, Foroozesh, W L, Alworth, E S, Roberts, P F, Hollenberg, J R, Halpert
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
Rabbit cytochromes P-450 (P-450) 2B4 and 2B5 differ by only 12 amino acid residues yet they exhibit unique steroid hydroxylation profiles. Previous studies have led to the identification of active site residues that are determinants of these specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3586e3ded6ab86b4f0f6802242c8d7a6
https://pubmed.ncbi.nlm.nih.gov/10381811
https://pubmed.ncbi.nlm.nih.gov/10381811
Autor:
J K, Doerr-Stevens, J, Liu, G J, Stevens, J C, Kraner, S M, Fontaine, J R, Halpert, I G, Sipes
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(2)
4-Vinylcyclohexene (VCH), an ovarian toxicant in mice, is known to irreversibly deplete ovarian follicles as a consequence of VCH diepoxide formation. Because ovotoxicity requires repeated dosing of VCH, the effect of consecutive daily doses of VCH (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a22fbc335b042f3468d5b82b638f103d
https://pubmed.ncbi.nlm.nih.gov/9929517
https://pubmed.ncbi.nlm.nih.gov/9929517
Autor:
J R, Halpert, T L, Domanski, O, Adali, C P, Biagini, J, Cosme, E A, Dierks, E F, Johnson, J P, Jones, P, Ortiz de Montellano, R M, Philpot, O, Sibbesen, W K, Wyatt, Z, Zheng
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(12)
This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f3f43f7c320a9586f1387fd6bbf8a6c
https://pubmed.ncbi.nlm.nih.gov/9860932
https://pubmed.ncbi.nlm.nih.gov/9860932
Autor:
J R, Halpert
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a9713918f5ad8336f0d2f29a7070855
https://pubmed.ncbi.nlm.nih.gov/9860920
https://pubmed.ncbi.nlm.nih.gov/9860920
Autor:
G D, Szklarz, J R, Halpert
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(12)
Three-dimensional homology models of cytochromes P450 (P450) 2B1 and P450 3A4 have been utilized along with site-directed mutagenesis to elucidate the molecular determinants of substrate specificity. Most of the key residues identified in 2B enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d773d39bde004edddf0a2324e70792a
https://pubmed.ncbi.nlm.nih.gov/9860924
https://pubmed.ncbi.nlm.nih.gov/9860924