Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J R, Gnarra"'
Publikováno v:
Proceedings of the National Academy of Sciences. 98:1387-1392
Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL −/− RCC). Loss of VHL protein function is associated with constitutive expression of mRNAs encoding hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f58796895cef1de954056f31d6a526
https://doi.org/10.1073/pnas.98.4.1387
https://doi.org/10.1073/pnas.98.4.1387
Autor:
F M Marincola, P Shamamian, R B Alexander, J R Gnarra, R L Turetskaya, S A Nedospasov, T B Simonis, J K Taubenberger, J Yannelli, A Mixon
Publikováno v:
The Journal of Immunology. 153:1225-1237
The expression of HLA class I molecules on tumor cells is vital for CD8+T cell recognition of tumor Ags. Loss of HLA class I Ag expression as a result of defective beta 2-microglobulin genes has been described in melanoma cells. To further evaluate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c896b2477e83f209f34f5ae65dedfe6
https://doi.org/10.4049/jimmunol.153.3.1225
https://doi.org/10.4049/jimmunol.153.3.1225
Publikováno v:
The American journal of pathology. 149(6)
Patients with von Hippel-Lindau (VHL) disease develop a spectrum of bilateral clear-cell renal lesions including cysts and renal cell carcinomas (RCCs). VHL gene deletions have been previously reported in VHL-associated macroscopic RCC. Although hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::912fb98c96ea1a1d64694868a77226e1
https://pubmed.ncbi.nlm.nih.gov/8952541
https://pubmed.ncbi.nlm.nih.gov/8952541
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 9(8)
The von Hippel-Lindau (VHL) disease gene on chromosome 3p25.5 has been cloned and shown to be mutated in the germline DNA of patients with VHL disease. In addition, approximately 60% of sporadic renal cell carcinomas (RCCs) have been shown to have a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::251080983b213d779f528977fc163d6f
https://pubmed.ncbi.nlm.nih.gov/8871925
https://pubmed.ncbi.nlm.nih.gov/8871925
Autor:
J R, Gnarra, G R, Dressler
Publikováno v:
Cancer research. 55(18)
Renal cell carcinoma (RCC) is the most common malignancy in the adult kidney. Because RCC is generally thought to arise from the epithelium of the proximal tubules, the expression of Pax-2, a gene required for renal epithelium development, was examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::589d17eea75acfffadda8f01cf687cdd
https://pubmed.ncbi.nlm.nih.gov/7664285
https://pubmed.ncbi.nlm.nih.gov/7664285
Publikováno v:
Cancer genetics and cytogenetics. 82(2)
Successful cytogenetic analysis was performed on 27 samples from 25 patients with RCC, including 7 of 11 tumors studied and 20 cell lines. Clonal chromosomal abnormalities were detected in all 27 samples. The most frequently involved chromosomes were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68fc6ae7b4b2e3ea4f9bb7001d407e5b
https://pubmed.ncbi.nlm.nih.gov/7664242
https://pubmed.ncbi.nlm.nih.gov/7664242
Autor:
M M, Walther, J R, Gnarra, L, Elwood, H J, Xu, C, Florence, P, Anglard, S X, Hu, C, King, E, Trahan, K, Hurley
Publikováno v:
The Journal of urology. 153(6)
Tumor suppressor genes have been found to have loss of function in a number of malignancies. This loss of function is believed to contribute to malignant transformation or metastatic spread. In the present study, expression of the retinoblastoma (RB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::486aadd69d85185bcaafe0f05ef1d98f
https://pubmed.ncbi.nlm.nih.gov/7752392
https://pubmed.ncbi.nlm.nih.gov/7752392
Publikováno v:
Surgical oncology clinics of North America. 4(2)
The combined efforts of a number of investigators have led to the identification of the VHL gene, which appears to function as a tumor suppressor gene and is implicated in both sporadic and familial forms of RCC. These findings should increase our un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1185b6885cedd3f21441a768ec0bf042
https://pubmed.ncbi.nlm.nih.gov/7796282
https://pubmed.ncbi.nlm.nih.gov/7796282
Publikováno v:
Seminars in oncology. 22(1)
Using a genetic linkage-based positional cloning approach the VHL gene was identified at chromosome 3p25.5. VHL is mutated in the germlines of affected individuals, and in VHL-associated tumors the mutation is almost always exposed by virtue of chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6820cfed1aff8bd52d74418ff7e4db3d
https://pubmed.ncbi.nlm.nih.gov/7855617
https://pubmed.ncbi.nlm.nih.gov/7855617
Autor:
F M, Marincola, P, Shamamian, R B, Alexander, J R, Gnarra, R L, Turetskaya, S A, Nedospasov, T B, Simonis, J K, Taubenberger, J, Yannelli, A, Mixon
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(3)
The expression of HLA class I molecules on tumor cells is vital for CD8+T cell recognition of tumor Ags. Loss of HLA class I Ag expression as a result of defective beta 2-microglobulin genes has been described in melanoma cells. To further evaluate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69d0885b7d5f769610b7229208b0e42d
https://pubmed.ncbi.nlm.nih.gov/8027550
https://pubmed.ncbi.nlm.nih.gov/8027550