Zobrazeno 1 - 10
of 59
pro vyhledávání: '"J R, Dimmock"'
Publikováno v:
Crystallography Reports. 66:985-990
Autor:
M, Hossain, S C, Hall, P J, Wiggington, S M, Roth, S, Das, U, Das, P K, Roayapalley, J R, Dimmock
Publikováno v:
Die Pharmazie. 77(3)
The present investigation involved the synthesis of a number of novel benzylidene hydrazides as candidate cytotoxic agents. The preparation of these compounds from terephthalic acid and isophthalic acid proceeded satisfactorily. However, the reaction
1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)4-piperidones: a novel class of antimycobacterial agents
Autor:
A, Jha, J R, Dimmock
Publikováno v:
Die Pharmazie. 61(6)
Various acyl groups possessing markedly divergent topography were placed on the nitrogen atom of the antimycobacterial agent 3,5-bis(phenylmethylene)-4-piperidone (1). Some of the N-maleamoyl analogues of 1 displayed antitubercular properties thereby
Autor:
J R, Dimmock, G A, Zello, S C, Vashishtha, S J, Hayes, S, Mutalik, S, Kumar, M, Venkatesh, N, Udupa
Publikováno v:
Die Pharmazie. 58(2)
2-Dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride (3) is a novel cytotoxic and anticancer agent. The objective of this study was to obtain information pertaining to possible toxic symptoms detected by in vivo evaluations in mice and an in v
Publikováno v:
Die Pharmazie. 56(9)
Autor:
S C, Vashishtha, T M, Allen, S, Halleran, J, Szydlowski, C L, Santos, E, De Clercq, J, Balzarani, J R, Dimmock
Publikováno v:
Die Pharmazie. 56(5)
A previous investigation revealed that various 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinols and related vinylogs were cytotoxic to both murine and human tumour cell lines. In particular, 1a and 2a were identified as useful prototypic molecules. Struc
Publikováno v:
Die Pharmazie. 55(7)
The results from a previous study led to the postulate that a number of aryl semicarbazones displaying anticonvulsant activity in the maximal electroshock (MES) screen interacted at both a hydrophobic and a hydrogen bonding areas on a specific bindin
Publikováno v:
Current medicinal chemistry. 6(12)
This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as
Publikováno v:
Die Pharmazie. 54(4)
4-(4-Fluorophenoxy)benzaldehyde semicarbazone (1) is a novel anticonvulsant affording excellent protection in the rat oral maximal electroshock (MES) screen as well as having an apparent protection index of over 300. The metabolism of this compound w
Publikováno v:
Die Pharmazie. 53(10)
A series of 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides demonstrated marked cytotoxicity towards approximately 55 human tumour cell lines from different neoplastic diseases. In general they were more potent than melphalan and displayed