Zobrazeno 1 - 10
of 187
pro vyhledávání: '"J R, Claude"'
Publikováno v:
Chromatographia. 50:721-727
An isocratic high-performance liquid-chromatographic (HPLC) procedure with diode-array detection has been developed for the determination of benzoylecgonine, cocaine, and cocaethylene in urine, serum, and saliva. After solid-phase extraction with mix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3b7ac0870f2639393edd6b9cffde3e
https://doi.org/10.1007/bf02497311
https://doi.org/10.1007/bf02497311
Autor:
B. Do, J. R. Claude, D. Durand, R. Breget, Jean-Michel Warnet, X. Do Thanh, F. Massicot, N. Taniguchi, J. P. Clot
Publikováno v:
General Pharmacology: The Vascular System. 31:459-462
1. The effects of 24R,25-dihydroxyvitamin D3 [24,25(OH)2D3] on alkaline phosphatase activity (ALP) were evaluated in pig kidney LLC-PK1 cells in culture. 2. The vitamin D3 metabolite increased ALP activity in these cells, whereas no effect of the hor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e70b15194e4e6f0359a1fcbe03c1e8b
https://doi.org/10.1016/s0306-3623(98)00011-1
https://doi.org/10.1016/s0306-3623(98)00011-1
Autor:
C. Martin, M. Hamon, Jean-Michel Warnet, J. R. Claude, T. Becue, G. Mahuzier, C. Pham-Huy, Nouredine Sadeg
Publikováno v:
Archives of Toxicology. 69:346-349
Cyclosporin A (CsA) is in vivo mainly metabolized by hepatic cytochrome P450 IIIA to more than 21 metabolites, the major ones known as: M1, M17 and M21. The aim of this work is to explore the in vitro metabolism of CsA after incubation, in the presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb47ed39f2b50bb2631febe3592e65e
https://doi.org/10.1007/s002040050182
https://doi.org/10.1007/s002040050182
Publikováno v:
Drug and Chemical Toxicology. 18:105-117
Alteration of calcium homeostasis has been proposed to play a major role in cell necrosis induced by a variety of chemical agents such as acetaminophen (APAP). In this study, a potential protective effect of the dihydropyridine calcium channel blocki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef8fc861a22bd8f0e90cef3d2e775d3
https://doi.org/10.3109/01480549509014315
https://doi.org/10.3109/01480549509014315
Autor:
J. R. Claude, V. Levresse, J.P. Gramond, A. Sahui-Gnassi, Hervé Galons, S. Ellouk-Achard, V. Saada, C. Pham-Huy, D. Fompeydie
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 12:1189-1198
A microdetermination of propranolol enantiomers and of their glucuronide and sulphate conjugates in human plasma and urine by reversed-phase HPLC after chiral derivatization is described. After extraction from 100 μl of plasma or urine with racemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48edc68e3ff17761106f4094ac1c5c9f
https://doi.org/10.1016/0731-7085(94)e0028-y
https://doi.org/10.1016/0731-7085(94)e0028-y
Publikováno v:
Drug and Chemical Toxicology. 17:449-462
This study was designed to assess Cyclosporin A (CsA) nephrotoxicity in the rabbit-possibly a more sensitive species than the rat-and to explore the mechanism of this toxicity with special attention to glutathione metabolism disturbances and cytochro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693df544654ac7ffd4243c478c012bc4
https://doi.org/10.3109/01480549409014311
https://doi.org/10.3109/01480549409014311
Autor:
J. R. Claude
Publikováno v:
Comparative Haematology International. 3:174-177
The aim of this paper is to emphasize the necessity of an international harmonisation of the guidelines in toxicology for the safety evaluation of pharmaceutical products, and the role of the International Conference on Harmonization (ICH). The organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a861f214b26ce32ed55ddb3dd7327788
https://doi.org/10.1007/bf00186103
https://doi.org/10.1007/bf00186103
Publikováno v:
Drug and Chemical Toxicology. 16:165-174
Rabbit renal microsomes were used to investigate the effect on lipid peroxidation (LPO) of cyclosporin A (CsA) and its first generation metabolites M1, M17 and M21, and of two natural CsA analogs: cyclosporins C and D (CsCCsD respectively), at concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb9a4a860bb1614230119ca385119d5
https://doi.org/10.3109/01480549309031994
https://doi.org/10.3109/01480549309031994
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250b86fed8c20a07e4d70d541c4439f7
https://doi.org/10.1002/chin.199543169
https://doi.org/10.1002/chin.199543169
Publikováno v:
Analytical Letters. 24:603-623
A rapid microdetermination of amiodarone (A) and its metabolite, N. Desethylamiodarone (DA) in plasma by HPLC is described. 100μL of plasma are deproteinized by 200μL of acetonitrile containing triflupromazine as an internal standard. After centrif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974a8b056c80a607a53dd6e32b73b611
https://doi.org/10.1080/00032719108052930
https://doi.org/10.1080/00032719108052930