Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J R, Carson"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 28:101-105
RWJ-37874, an analogue of aroyl(aminoacyl)pyrrole, is a new analgesic agent. The in vitro metabolism of RWJ-37874 was conducted using rat and human hepatic S9 in the presence of an NADPH generating system, and API-ionspray-MS and MS/MS techniques for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b7db8206bf1ce2d54597eaecc3846b
https://doi.org/10.1007/bf03190496
https://doi.org/10.1007/bf03190496
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 28(2)
RWJ-51784, an analogue of phenyl isoindoles, is a new analgesic agent. The in vitro metabolism of RWJ-51784 was conducted using rat, dog and human hepatic S9 in the presence of an NADPH generating system, and API-ionspray-MS and MS/MS techniques for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6a9d57930d6711c3801ca557d1178c
https://pubmed.ncbi.nlm.nih.gov/12877567
https://pubmed.ncbi.nlm.nih.gov/12877567
Autor:
B L, Podlogar, G I, Poda, D A, Demeter, S P, Zhang, J R, Carson, L A, Neilson, A B, Reitz, D M, Ferguson
Publikováno v:
Drug design and discovery. 17(1)
A series of 4-(N,N-diarylamino)piperidines are synthesized and evaluated for high affinity binding and selectivity to the delta-opioid receptor using a combination of 3D-QSAR and molecular docking techniques. Based on experimental ligand binding data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a4ad9ec4fa0c61a3e5656a022d6b86d
https://pubmed.ncbi.nlm.nih.gov/10928448
https://pubmed.ncbi.nlm.nih.gov/10928448
Autor:
B. E. Watkins, C. J. Hewitt, B. W. Bellow, A. E. Moeller, H. A. Johnsen, H. Fry, R. L. Peabody, S. M. Williams, R. f. Boehm, J. R. Stephens, J. C. Swearengen, R. L. Heinle, T. J. Tope, D. Steele, C. O. Pruneda, D. K. Ottesen, W. C. Thomas, C. A. Velsko, W. C. Gray, H. H. Hirano, Christopher R. Shaddix, J. Lipkin, K. J. Stetzenback, J. A. Sanchez, S. W. Allendorf, A. Smiecinski, L. R. Carrillo, J. R. Carson
Three low-pressure rocket motor burn tests were executed in May--June 1997 time frame at the X-tunnel complex located on the Department of Energy's Nevada Test Site.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7723d69f1040a058840fee6f36ce9c
https://doi.org/10.2172/750891
https://doi.org/10.2172/750891
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(2)
The excretion and metabolism of a 2-ethynylbenzenealkanamine analog, antihypertensive RWJ-26240 (McN-5691), in beagle dogs was investigated. Recoveries of total radioactivity in urine and feces in the 7 days after oral administration of 14C-RWJ-26240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38f1ad1b1e355317160c897763ae41b9
https://pubmed.ncbi.nlm.nih.gov/9456297
https://pubmed.ncbi.nlm.nih.gov/9456297
Autor:
S F, Flaim, M M, Gleason, A, Hedberg, R P, Shank, J R, McCullough, A, Gill, B P, Damiano, M D, Brannan, J R, Carson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 256(1)
These studies were conducted to gain greater understanding of the mechanism of action of the chemically novel antihypertensive agent, McN-5691. McN-5691 (1 and 10 microM) prevented 60 mM KCl-induced contraction and calcium uptake and caused concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3c16fb7fb92cb7113195029efa2d6f8
https://pubmed.ncbi.nlm.nih.gov/1846419
https://pubmed.ncbi.nlm.nih.gov/1846419
Autor:
J L, Vaught, J R, Carson, R J, Carmosin, P S, Blum, F J, Persico, W E, Hageman, R P, Shank, R B, Raffa
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 255(1)
McN-5195 [(+/-)-trans-3-(2-bromophenyl)-octahydroindolizine] inhibited at nontoxic doses the nociceptive response in tail-pinch, tail-flick and 48 degrees C hot-plate tests of mice, with ED50 values of 38.2, 33.9 and 30.9 mg/kg i.p., respectively, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26ed9422a21074e4f2f2b446211765c5
https://pubmed.ncbi.nlm.nih.gov/2170621
https://pubmed.ncbi.nlm.nih.gov/2170621
Publikováno v:
Genetics. 97:443-456
Cornell Control White Leghorn chicks were grown in a common environment to five weeks of age and selected for fast and slow gain in body weight from five to nine weeks of age at two temperatures, 21.1° (cold) and 32.2° (hot), during which time a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb125a2ccbcc4d85766d79c2dd2016dc
https://doi.org/10.1093/genetics/97.2.443
https://doi.org/10.1093/genetics/97.2.443
Autor:
J. R. Carson
Publikováno v:
Poultry Science. 54:1581-1584
S.C. White Leghorn pullets were placed on feed and water on the day of hatching or 1 or 2 days after the day of hatching. Precision block type debeaking was performed with a Lyon’s electric debeaker immediately before feeding and watering. Debeakin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7038351f019955b70884e9fd3c0cdbe8
https://doi.org/10.3382/ps.0541581
https://doi.org/10.3382/ps.0541581
Autor:
J R, Carson, H R, Almond, M D, Brannan, R J, Carmosin, S F, Flaim, A, Gill, M M, Gleason, S L, Keely, D W, Ludovici, P M, Pitis
Publikováno v:
Journal of Medicinal Chemistry. 31:630-636
A series of 2-(aryl- or alkylethynyl)benzenealkanamines were synthesized. They exhibit antihypertensive activity in spontaneously hypertensive rats and coronary vasodilator activity with minimal negative inotropic activity in the "Langendorff" guinea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830743270fcfa0496e7a801ebf93ae52
https://doi.org/10.1021/jm00398a023
https://doi.org/10.1021/jm00398a023