Zobrazeno 1 - 10
of 1 397
pro vyhledávání: '"J Pike"'
Autor:
Bani Medegan Fagla, Jason York, Amy Christensen, Cielo Dela Rosa, Deebika Balu, Christian J. Pike, Leon M. Tai, Irina A. Buhimschi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Apolipoprotein E (APOE) is a major cholesterol carrier responsible for lipid transport and injury repair in the brain. The human APOE gene (h-APOE) has 3 naturally occurring alleles: ε3, the common allele; ε4, which increases Alzheimer’s
Externí odkaz:
https://doaj.org/article/d52b5cb7d04649789fb8838ad926c11e
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The main genetic risk factor for Alzheimer’s disease (AD) is the apolipoprotein E ε4 allele (APOE4). AD risk associated with APOE4 disproportionately affects women. Furthermore, human and rodent studies indicate that the cognitive deficits associa
Externí odkaz:
https://doaj.org/article/b950fa47c55d441d8987df43b3444ead
Autor:
Christopher V McCabe, Peter D Price, Gemma F Codner, Alasdair J Allan, Adam Caulder, Skevoulla Christou, Jorik Loeffler, Matthew Mackenzie, Elke Malzer, Joffrey Mianné, Krystian J Nowicki, Edward J O'Neill, Fran J Pike, Marie Hutchison, Benoit Petit-Demoulière, Michelle E Stewart, Hilary Gates, Sara Wells, Nicholas D Sanderson, Lydia Teboul
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011187 (2024)
BackgroundRecent developments in CRISPR/Cas9 genome-editing tools have facilitated the introduction of precise alleles, including genetic intervals spanning several kilobases, directly into the embryo. However, the introduction of donor templates, vi
Externí odkaz:
https://doaj.org/article/bb312da1ed8649b9bf1f17a2c3bba609
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-7 (2022)
Abstract The most significant genetic risk factor for developing late-onset Alzheimer’s disease (AD) is the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key modulators of microglial and astroglial function, which exe
Externí odkaz:
https://doaj.org/article/8d6c4e8cfdff42199c50168849c16ea9
Autor:
X. Crosta, K. E. Kohfeld, H. C. Bostock, M. Chadwick, A. Du Vivier, O. Esper, J. Etourneau, J. Jones, A. Leventer, J. Müller, R. H. Rhodes, C. S. Allen, P. Ghadi, N. Lamping, C. B. Lange, K.-A. Lawler, D. Lund, A. Marzocchi, K. J. Meissner, L. Menviel, A. Nair, M. Patterson, J. Pike, J. G. Prebble, C. Riesselman, H. Sadatzki, L. C. Sime, S. K. Shukla, L. Thöle, M.-E. Vorrath, W. Xiao, J. Yang
Publikováno v:
Climate of the Past, Vol 18, Pp 1729-1756 (2022)
Antarctic sea ice plays a critical role in the Earth system, influencing energy, heat and freshwater fluxes, air–sea gas exchange, ice shelf dynamics, ocean circulation, nutrient cycling, marine productivity and global carbon cycling. However, accu
Externí odkaz:
https://doaj.org/article/2923f803a8634ecfab7fc6b52554c01a
Autor:
Samuel C. Forster, Junyan Liu, Nitin Kumar, Emily L. Gulliver, Jodee A. Gould, Alejandra Escobar-Zepeda, Tapoka Mkandawire, Lindsay J. Pike, Yan Shao, Mark D. Stares, Hilary P. Browne, B. Anne Neville, Trevor D. Lawley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Here, Forster et al. compare 1354 cultured commensal strains (540 species) to 45,403 pathogen strains (12 species), identifying 64,188 MGE-mediated antibiotic resistance gene transfer events between the two groups, and show that 15 broad host range M
Externí odkaz:
https://doaj.org/article/6b3f3a14687c4d9ea992587fbf554cd6
Autor:
Elizabeth C. J. Pike, Andy Smith
Publikováno v:
Frontiers in Sociology, Vol 7 (2023)
Externí odkaz:
https://doaj.org/article/426fe9bfc4dd40ed9f0da86594d66c4d
Autor:
Amy Christensen, Christian J. Pike
Publikováno v:
Metabolites, Vol 13, Iss 2, p 287 (2023)
Western diets high in sugars and saturated fats have been reported to induce metabolic and inflammatory impairments that are associated with several age-related disorders, including Alzheimer’s disease (AD) and type 2 diabetes (T2D). The apolipopro
Externí odkaz:
https://doaj.org/article/f1a1e401f27a473ebe74a9c768bdd401
Autor:
V. Alexandra Moser, Michael J. Workman, Samantha J. Hurwitz, Rachel M. Lipman, Christian J. Pike, Clive N. Svendsen
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103238- (2021)
Summary: Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 is known to affect the function of microglia, but to what extent this gene drives microglial gene expression has thus far not been
Externí odkaz:
https://doaj.org/article/fd27aedfef3942159b202a822dc10a26
Autor:
Hao Chung The, Chau Nguyen Ngoc Minh, Chau Tran Thi Hong, To Nguyen Thi Nguyen, Lindsay J. Pike, Caroline Zellmer, Trung Pham Duc, Tuan-Anh Tran, Tuyen Ha Thanh, Minh Pham Van, Guy E. Thwaites, Maia A. Rabaa, Lindsay J. Hall, Stephen Baker
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Bifidobacterium pseudocatenulatum is a member of the human gut microbiota, and specific variants of B. pseudocatenulatum have been associated with health benefits such as improving gut integrity and reducing inflammatory responses. Here, we
Externí odkaz:
https://doaj.org/article/d40680d2ec7b4e96b21ad8e91e932f52