Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.

Autor: Xiaoqing Rong-Mullins, Apoorva Ravishankar, Kirsten A McNeal, Zachery R Lonergan, Audrey C Biega, J Philip Creamer, Jennifer E G Gallagher

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187522 (2017)

S. cerevisiae from different environments are subject to a wide range of selective pressures, whether intentional or by happenstance. Chemicals classified by their application, such as herbicides, fungicides and antibiotics, can affect non-target org

Externí odkaz: https://doaj.org/article/54063b3384154cd9bff273703535eaf4

Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells

Autor: Stephanie A. Luff, J. Philip Creamer, Sara Valsoni, Carissa Dege, Rebecca Scarfò, Analisa Dacunto, Sara Cascione, Lauren N. Randolph, Eleonora Cavalca, Ivan Merelli, Samantha A. Morris, Andrea Ditadi, Christopher M. Sturgeon

Publikováno v: Nature cell biology 24 (2022): 616–+. doi:10.1038/s41556-022-00898-9
info:cnr-pdr/source/autori:Luff, Stephanie A.; Creamer, J. Philip; Valsoni, Sara; Dege, Carissa; Scarfo, Rebecca; Dacunto, Analisa; Cascione, Sara; Randolph, Lauren N.; Cavalca, Eleonora; Merelli, Ivan; Morris, Samantha A.; Ditadi, Andrea; Sturgeon, Christopher M./titolo:Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells/doi:10.1038%2Fs41556-022-00898-9/rivista:Nature cell biology/anno:2022/pagina_da:616/pagina_a:+/intervallo_pagine:616–+/volume:24

The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. During embryonic development, HSCs derive from haemogenic endothelium (HE) in a NOTCH- and retinoic acid (RA)-depe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c7a8059e84cddfa73f22fec5797134
https://pubmed.ncbi.nlm.nih.gov/35484246

Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function

Autor: Andreea Reilly, J. Philip Creamer, Sintra Stewart, Massiel C. Stolla, Yuchuan Wang, Jing Du, Rachel Wellington, Stephanie Busch, Elihu H. Estey, Pamela S. Becker, Min Fang, Siobán B. Keel, Janis L. Abkowitz, Lorinda A. Soma, Jian Ma, Zhijun Duan, Sergei Doulatov

Publikováno v: Cell Stem Cell

Abnormal nuclear morphology is a hallmark of malignant cells widely used in cancer diagnosis. Pelger-Huët anomaly (PHA) is a common abnormality of neutrophil nuclear morphology of unknown molecular etiology in myeloid neoplasms (MNs). We show that l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55db33060ab8fdba95c1263ad548c0c8
https://pubmed.ncbi.nlm.nih.gov/35395184

Modeling Clonal Progression in SF3B1-Mutant Myelodysplastic Syndrome

Autor: Luca Malcovati, Gabriele Todisco, Sergei Doulatov, J. Philip Creamer, Martina Sarchi, Anna Gallì, Courtnee Clough

Publikováno v: Blood. 138:149-149

SF3B1-mutant myelodysplastic syndrome (MDS) has recently been proposed as a distinct disorder characterized by ring sideroblasts, ineffective erythropoiesis and good prognosis. Selected co-occurring genetic abnormalities were reported associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05da30be2b03cb13e94da1651fa0a4ac
https://doi.org/10.1182/blood-2021-151619

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development

Autor: Stephanie A. Luff, Carissa Dege, Katherine H. Fegan, Melissa M. Berrien-Elliott, Darren Kim, James Palis, Todd A. Fehniger, J. Philip Creamer, Kathleen E. McGrath, Christopher M. Sturgeon, Julia A. Wagner, Paul D. Kingsley

Publikováno v: Dev Cell

Summary Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK cell potential first arises from Hoxaneg/low Kit+CD41+CD16/32+ hematopoietic-stem-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d22bbbce1101d2c20952015f8bb5b5d
https://pubmed.ncbi.nlm.nih.gov/32197069