Zobrazeno 1 - 10
of 1 298
pro vyhledávání: '"J Phelan"'
Autor:
Donal J Cox, Sarah A Connolly, Cilian Ó Maoldomhnaigh, Aenea AI Brugman, Olivia Sandby Thomas, Emily Duffin, Karl M Gogan, Oisin Ó Gallchobhair, Dearbhla M Murphy, Sinead A O'Rourke, Finbarr O'Connell, Parthiban Nadarajan, James J Phelan, Laura E Gleeson, Sharee A Basdeo, Joseph Keane
Publikováno v:
eLife, Vol 13 (2024)
Airway macrophages (AM) are the predominant immune cell in the lung and play a crucial role in preventing infection, making them a target for host directed therapy. Macrophage effector functions are associated with cellular metabolism. A knowledge ga
Externí odkaz:
https://doaj.org/article/9c3246ecbdeb45c6a9668ba8b1cd623a
Autor:
Daniel J. Phelan
Arguably, the nation's community colleges have experienced more change in the last several years than they have over the prior 115 years of their existence. Rapid changes in technology, external pressures for accountability and student completion, ag
Autor:
Maria Davern, Caoimhe Gaughan, Fiona O’ Connell, Brendan Moran, Eimear Mylod, Andrew D. Sheppard, Sinead Ramjit, Jasmine Yun-Tong Kung, James J. Phelan, Matthew G. Davey, Eanna J. Ryan, Christine Butler, Laura Quinn, Claudine Howard, Emily Tone, Eimear Phoenix, Waqas T. Butt, Niamh Lynam-Lennon, Stephen G. Maher, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Noel E. Donlon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThis timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal canc
Externí odkaz:
https://doaj.org/article/e9a76b77fe4448bca0dc1485f4477ae2
Autor:
Dearbhla M. Murphy, Donal J. Cox, Sarah A. Connolly, Eamon P. Breen, Aenea A.I. Brugman, James J. Phelan, Joseph Keane, Sharee A. Basdeo
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
Background Heterologous effects of vaccines are mediated by “trained immunity,” whereby myeloid cells are metabolically and epigenetically reprogrammed, resulting in heightened responses to subsequent insults. Adenovirus vaccine vector has been r
Externí odkaz:
https://doaj.org/article/24b44d5422e842b18d691bd5b2e4fc5e
Defining the role of neutrophils in the lung during infection: Implications for tuberculosis disease
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Neutrophils are implicated in the pathogenesis of many diseases involving inflammation. Neutrophils are also critical to host defence and have a key role in the innate immune response to infection. Despite their efficiencies against a wide range of p
Externí odkaz:
https://doaj.org/article/7a953f9a77b4491187f600435bc18ca9
Autor:
Abigail Keogan, Thi Nguyet Que Nguyen, James J. Phelan, Naoimh O'Farrell, Niamh Lynam‐Lennon, Brendan Doyle, Dermot O'Toole, John V. Reynolds, Jacintha O'Sullivan, Aidan D. Meade
Publikováno v:
Translational Biophotonics, Vol 3, Iss 4, Pp n/a-n/a (2021)
Abstract Fourier Transform Infrared (FTIR) based chemical imaging is a powerful, non‐destructive and label‐free biophotonic technique, which spatially acquires bio‐molecularly relevant information in histopathology. Cancer detection with object
Externí odkaz:
https://doaj.org/article/63b24369954a41efb8aabbedac63d2eb
Autor:
Cilian Ó Maoldomhnaigh, Donal J. Cox, James J. Phelan, Morgane Mitermite, Dearbhla M. Murphy, Gina Leisching, Lorraine Thong, Seónadh M. O’Leary, Karl M. Gogan, Kate McQuaid, Amy M. Coleman, Stephen V. Gordon, Sharee A. Basdeo, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In order to mount an appropriate immune response to infection, the macrophage must alter its metabolism by increasing aerobic glycolysis and concomitantly decreasing oxidative phosphorylation; a process known as the Warburg effect. Consequently, lact
Externí odkaz:
https://doaj.org/article/a9b01451cc7f44639429c99ff0a2bc3b
Publikováno v:
Particle and Fibre Toxicology, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced c
Externí odkaz:
https://doaj.org/article/571efd3d8e5e433a861ff2412e0c4bfd
Publikováno v:
Clinical Nephrology. 99:191-196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50b77c0cfa4d2c5e83263d4e2a765d4
https://doi.org/10.5414/cn110998
https://doi.org/10.5414/cn110998