Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes

Autor: B Rubinfeld, B Schryver, P Polakis, J Papkoff

Publikováno v: Molecular and Cellular Biology. 16:2128-2134

The Wnt-1 proto-oncogene induces the accumulation of beta-catenin and plakoglobin, two related proteins that associate with and functionally modulate the cadherin cell adhesion proteins. Here we have investigated the effects of Wnt-1 expression on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afab596b6f7cb28881d11391cac9a75
https://doi.org/10.1128/mcb.16.5.2128

Wnt family proteins are secreted and associated with the cell surface

Autor: J Papkoff, B D Smolich, J A McMahon, A P McMahon

Publikováno v: Molecular Biology of the Cell. 4:1267-1275

Members of the Wnt gene family are proposed to function in both normal development and differentiation as well as in mammary tumorigenesis. To understand the function of Wnt proteins in these two processes, we present here a biochemical characterizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebec25f10b2dd53f14f00a7491f68ecc
https://doi.org/10.1091/mbc.4.12.1267

Inhibition of tumor growth correlates with the expression level of a human angiostatin transgene in transfected B16F10 melanoma cells

Autor: S, Ambs, S, Dennis, J, Fairman, M, Wright, J, Papkoff

Publikováno v: Cancer research. 59(22)

Although the therapeutic value of angiostatin, a proteolytic fragment of plasminogen, has been recognized for the treatment of cancer, the production of bioactive angiostatin remains a difficult task. Here we report that expression of a cDNA encoding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07839ba3360f900c94ebdb3ee2511fa8
https://pubmed.ncbi.nlm.nih.gov/10582698

Regulation of complexed and free catenin pools by distinct mechanisms. Differential effects of Wnt-1 and v-Src

Autor: J, Papkoff

Publikováno v: The Journal of biological chemistry. 272(7)

Cadherins are transmembrane receptors with an extracellular domain that participates in homophilic cell to cell adhesion and a cytoplasmic domain that associates with proteins called catenins. Cadherin-mediated adhesion as well as adhesion-independen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f33a897ef67a37dc6e47d8d5b4a50c1
https://pubmed.ncbi.nlm.nih.gov/9020180

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells

Autor: Jason R. Swedlow, W J Nelson, J Papkoff, Lindsay Hinck, Inke S. Näthke

Publikováno v: The Journal of Cell Biology
Näthke, IS; Hinck, L; Swedlow, JR; Papkoff, J; & Nelson, WJ. (1994). Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.. The Journal of cell biology, 125(6), 1341-1352. doi: 10.1083/jcb.125.6.1341. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/13t3c1r7
The Journal of cell biology, vol 125, iss 6

The cadherin/catenin complex plays important roles in cell adhesion, signal transduction, as well as the initiation and maintenance of structural and functional organization of cells and tissues. In the preceding study, we showed that the assembly of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b20bc4c38faec01c2b24855a015857
https://pubmed.ncbi.nlm.nih.gov/8207062