L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy

Autor: H. Angharad Watson, Ruban R. P. Durairaj, Julia Ohme, Markella Alatsatianos, Hanan Almutairi, Rebar N. Mohammed, Miriam Vigar, Sophie G. Reed, Stephen J. Paisey, Christopher Marshall, Awen Gallimore, Ann Ager

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The homing molecule, L-selectin (CD62L), is commonly used as a T cell activation marker, since expression is downregulated following engagement of the T cell receptor. Studies in mice have shown that CD62L+ central memory T cells are better at contro

Externí odkaz: https://doaj.org/article/3f7f91648a5449e7a2df294752c4ba54

An economic evaluation of first-line cryoballoon ablation versus antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from an English NHS perspective

Autor: J Andrade, J Moss, D Todd, M Kuniss, O Wazni, G B Chierchia, S Mealing, A Sale, E Ismyrloglou, M Souter, T Bromilow, E Lane, D Lewis, J Paisey

Publikováno v: Europace. 25

Funding Acknowledgements Type of funding sources: Other. Main funding source(s): This cost-effectiveness study was funded by Medtronic Background The UK National Institute of Care Excellence (NICE) recommend the use of pulmonary vein isolation (PVI)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85064dc52530331d9f26804419d089ec
https://doi.org/10.1093/europace/euad122.688

Biodistribution PET/CT Study of Hemoglobin-DFO-89Zr Complex in Healthy and Lung Tumor-Bearing Mice

Autor: Łukasz Kiraga, Gabriele Cerutti, Agata Braniewska, Damian Strzemecki, Zuzanna Sas, Alberto Boffi, Carmelinda Savino, Linda Celeste Montemiglio, Daniel Turnham, Gillian Seaton, Alessandra Bonamore, Richard Clarkson, Adam M. Dabkowski, Stephen J. Paisey, Bartłomiej Taciak, Paulina Kucharzewska, Tomasz P. Rygiel, Magdalena Król

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 14, p 4991 (2020)

Proteins, as a major component of organisms, are considered the preferred biomaterials for drug delivery vehicles. Hemoglobin (Hb) has been recently rediscovered as a potential drug carrier, but its use for biomedical applications still lacks extensi

Externí odkaz: https://doaj.org/article/de665128ffa64fbf93d9d13de855cdaf

Role of routine chest xrays and device checks in detecting peri-procedural complications associated with cardiac device implantation: a UK tertiary centre experience

Autor: C Menexi, M Elrefai, A Y T Chua, I Handa, M Abouelasaad, J Paisey

Publikováno v: European Heart Journal. 43

Introduction Complications associated with Cardiac implantable electronic devices (CIEDs) are not uncommon, most of which occur in the perioperative phase. Until recently, guidance on implemented measures for early detection of peri-operative complic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::403c60da9f223c3942c811eb909cc968
https://doi.org/10.1093/eurheartj/ehac544.709

Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF ‐1/ CXCR4 signalling pathway

Autor: Gaia Spinetti, Stephen J. Paisey, Ashton Faulkner, Zexu Dang, Elena Ciaglia, Aishah Alenzi, Annibale Alessandro Puca, Carmine Vecchione, Antonio D'Amato, Elisa Avolio, Albino Carrizzo, Nicoletta Finato, Paolo Madeddu, Anna Maciag, Yue Gu, Celeste Cervellin, Anita C Thomas, Antonio Paolo Beltrami

Publikováno v: Dang, Z, Avolio, E, Thomas, A C, Faulkner, A, Gu, Y, Madeddu, P R & al., E 2020, ' Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type-2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway ', European Journal of Heart Failure, vol. 22, no. 9, pp. 1568-1581 . https://doi.org/10.1002/ejhf.1840

Aims: Homozygosity for a 4-missense single-nucleotide-polymorphism-haplotype of the human BPIFB4 gene is enriched in long-living individuals. Delivery of this Longevity Associated Variant (LAV) improved revascularisation and reduced endothelial dysfu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e15cfb7fd2dc7350330357086ba1532
https://doi.org/10.1002/ejhf.1840