Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J P Rowan"'
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Autor:
Annie M. Goettemoeller, Emmie Banks, Prateek Kumar, Viktor J. Olah, Katharine E. McCann, Kelly South, Christina C. Ramelow, Anna Eaton, Duc M. Duong, Nicholas T. Seyfried, David Weinshenker, Srikant Rangaraju, Matthew J. M. Rowan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Preventative treatment for Alzheimer’s Disease (AD) is dire, yet mechanisms underlying early regional vulnerability remain unknown. In AD, one of the earliest pathophysiological correlates to cognitive decline is hyperexcitability, which i
Externí odkaz:
https://doaj.org/article/472c8a45309c4ce99d27485c1bbd846b
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Autor:
Mighten C. Yip, Mercedes M. Gonzalez, Christopher R. Valenta, Matthew J. M. Rowan, Craig R. Forest
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract A common electrophysiology technique used in neuroscience is patch clamp: a method in which a glass pipette electrode facilitates single cell electrical recordings from neurons. Typically, patch clamp is done manually in which an electrophys
Externí odkaz:
https://doaj.org/article/5db4cc70703448f39ca1561315d11c2a
Publikováno v:
eLife, Vol 7 (2018)
Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction w
Externí odkaz:
https://doaj.org/article/f939885e8b6644f88526190d9d3d688c
Publikováno v:
Hydrology and Earth System Sciences, Vol 19, Iss 8, Pp 3349-3363 (2015)
Soil erosion and suspended sediment (SS) pose risks to chemical and ecological water quality. Agricultural activities may accelerate erosional fluxes from bare, poached or compacted soils, and enhance connectivity through modified channels and artifi
Externí odkaz:
https://doaj.org/article/534f72cd2caf47ada27de08bd2c162fe
Publikováno v:
Biogeosciences, Vol 10, Iss 11, Pp 7133-7145 (2013)
Soil is a key asset of natural capital, providing a myriad of goods and ecosystem services that sustain life through regulating, supporting and provisioning roles, delivered by chemical, physical and biological processes. One of the greatest threats
Externí odkaz:
https://doaj.org/article/d0f07503d63348eb9257cf1fdd6bc556
Autor:
Samantha B Amat, Matthew J M Rowan, Michael A Gaffield, Audrey Bonnan, Chikako Kikuchi, Hiroki Taniguchi, Jason M Christie
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179347 (2017)
The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of the cerebellar cortex, therefore, any cerebellar involvement in motor activity must be driven by changes in PC firing rates. Several diff
Externí odkaz:
https://doaj.org/article/5a5971fc0bb9471b9ba326a726830076
Publikováno v:
Hydrology and Earth System Sciences, Vol 6, Iss 6, Pp 1007-1016 (2002)
Sediment fingerprinting is commonly used for sediment provenance studies in lakes, rivers and reservoirs and on hillslopes and floodplains. This investigation explores the mixing of terrestrial and marine-derived sediment in the Tay Estuary, Scotland
Externí odkaz:
https://doaj.org/article/1e6a57efc6d240c4bb9786784198f315
Autor:
G H Bothamley, Gene Feder, E. Beasley, M McDonald, J P Rowan, C van den Bosch, Chris Griffiths, M. Beeks
Publikováno v:
Thorax. 57(1)
Tuberculosis is increasing in London, especially in those recently entering the UK from an area of high incidence. Screening through the port of arrival scheme has a poor yield and has been considered discriminatory.A study was undertaken to compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0265334e8e98ed9159884e5b722e14a1
https://pubmed.ncbi.nlm.nih.gov/11809989
https://pubmed.ncbi.nlm.nih.gov/11809989