Zobrazeno 1 - 10
of 24
pro vyhledávání: '"J P McKearn"'
Publikováno v:
The Journal of Immunology. 144:3602-3610
The t(14;18) of human follicular B cell lymphoma translocates the Bcl-2 gene into the Ig H chain locus and markedly deregulates Bcl-2 expression. We sought to determine if Bcl-2 could be directly implicated in a growth-factor pathway. Consequently, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e67db6397092d6fe6699eff0f53d2bd2
https://doi.org/10.4049/jimmunol.144.9.3602
https://doi.org/10.4049/jimmunol.144.9.3602
Publikováno v:
Experimental hematology. 29(8)
Progenipoietin-1 is an agonist of both the granulocyte colony-stimulating factor and fetal liver tyrosine kinase-3 receptors capable of inducing the proliferation of multiple hematopoietic cell lineages. The potential of progenipoietin-1 to mobilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a858c01c9b57c5b9e40a384d87e86ba5
https://pubmed.ncbi.nlm.nih.gov/11495700
https://pubmed.ncbi.nlm.nih.gov/11495700
Autor:
P R, Streeter, N I, Minster, L E, Kahn, W F, Hood, L E, Vickery, T L, Thurman, J B, Monahan, J K, Welply, J P, McKearn, S L, Woulfe
Publikováno v:
Experimental hematology. 29(1)
The progenipoietins, a class of engineered proteins containing both fetal liver tyrosine kinase-3 and granulocyte colony-stimulating factor receptor agonist activities, were functionally characterized in vitro and in vivo. Four representative progeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59df87c901e781be41d62c4fb19e2c8d
https://pubmed.ncbi.nlm.nih.gov/11164104
https://pubmed.ncbi.nlm.nih.gov/11164104
Publikováno v:
Blood. 95(3)
Myelopoietins (MPOs) constitute a family of engineered, chimeric molecules that bind and activate the IL-3 and G-CSF receptors on hematopoietic cells. This study investigated the in vivo hematopoietic response of rhesus monkeys administered MPO after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f10e70ac0ea0ce160bd2d512a90dcff5
https://pubmed.ncbi.nlm.nih.gov/10648394
https://pubmed.ncbi.nlm.nih.gov/10648394
Publikováno v:
American journal of respiratory and critical care medicine. 154(2 Pt 1)
Inhaled E-type prostaglandins (PGE) have been shown to modulate responses to both allergic and nonallergic provocation. Misoprostol, a PGE1 analog, was developed as an antiulcer agent because it prevents gastrointestinal ulceration. Little is known a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f9fc5a892a5d6371cfcd6fd3a1d673
https://pubmed.ncbi.nlm.nih.gov/8756797
https://pubmed.ncbi.nlm.nih.gov/8756797
Publikováno v:
Blood. 87(10)
Combination cytokine therapy continues to be evaluated in an effort to stimulate multilineage hematopoietic reconstitution after bone marrow myelosuppression. This study evaluated the efficacy of combination therapy with the synthetic interleukin-3 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d596024d36e5ca84142850fbea37127
https://pubmed.ncbi.nlm.nih.gov/8639770
https://pubmed.ncbi.nlm.nih.gov/8639770
Publikováno v:
Blood. 87(2)
The synthetic cytokine (Synthokine) SC-55494 is a high-affinity interleukin-3 (IL-3) receptor ligand that stimulates greater in vitro multilineage hematopoietic activity than native IL-3, while inducing no significant increase in inflammatory activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47f3d3399d3bfbd013c54b8fc124d6e4
https://pubmed.ncbi.nlm.nih.gov/8555480
https://pubmed.ncbi.nlm.nih.gov/8555480
Autor:
D. J. Fretland, J. P. McKearn, M. Bremer, Stephen H. Docter, S. K. Paulson, S. W. Djuric, D. L. Widomski, Stella S. Yu, T. D. Penning, C. P. Anglin, Peter C. Isakson
Publikováno v:
Inflammation. 19(2)
Leukotriene B4 (LTB4) and 12(R)-hydroxyeicosatetraenoic acid [12(R)-HETE] are proinflammatory products of arachidonic acid metabolism that have been implicated as mediators in a number of inflammatory diseases. When injected intradermally into the gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff6cc962df83f387f35eae2f19703a7
https://pubmed.ncbi.nlm.nih.gov/7601505
https://pubmed.ncbi.nlm.nih.gov/7601505
Publikováno v:
British journal of rheumatology. 30
The synthetic prostaglandin misoprostol was found to enhance the immunosuppressive effects of cyclosporine A in vitro on human peripheral lymphocytes and mouse spleen cells, by synergizing with the latter drug, although on its own misoprostol was not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a517d9e4f5744863b2275e4fd79fcba8
https://pubmed.ncbi.nlm.nih.gov/1899625
https://pubmed.ncbi.nlm.nih.gov/1899625
Publikováno v:
Oncogene research. 6(1)
The myeloid interleukin-3 (IL-3) dependent cell line, FDC-P1, enters the G0 stage of the cell cycle after IL-3 deprivation for 24 hr. The expression of 13 protooncogenes and immediate-early genes was compared with 4 "control" genes after the addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c732bc2190bfe5e90706a9b4fa92bb1
https://pubmed.ncbi.nlm.nih.gov/1705318
https://pubmed.ncbi.nlm.nih.gov/1705318