Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J P Koepke"'
Autor:
Glenn J. Smits, Robert E. Manning, David B. Reitz, Edward H. Blaine, J P Koepke, Gillian M. Olins, Horng-Chih Huang
Publikováno v:
American Journal of Hypertension. 6:619-625
The depressor activity of a novel nonpeptidic angiotensin II (AII) receptor antagonist, SC-51316 (2,5-dibutyl-2,4-dihydro-4-[[2-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4 '- yl]-methyl]-3H-1,2,4-triazol-3-one), is described. In anesthetized, ganglion-blocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f982e285d59dab3a8331aa8a7eebde
https://doi.org/10.1093/ajh/6.7.619
https://doi.org/10.1093/ajh/6.7.619
Autor:
Kerry L. Spear, Gillian M. Olins, Philippe R. Bovy, Edward H. Blaine, Larry D. Tyler, Pramod P. Mehta, J P Koepke, Dale A. Hartupee, Angelo J. Trapani
Publikováno v:
American Journal of Hypertension. 3:622-627
We examined the interaction of a non-guanylate cyclase-linked atriopeptin (AP) binding site ligand, SC-46542 (des[Phe106,Gly107,Ala115,Gln116]AP-(103-126], and an endopeptidase 24.11 inhibitor, thiorphan, on mean arterial pressure, urinary sodium exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d40da04800d5cf207ca0b81d7d9c269
https://doi.org/10.1093/ajh/3.8.622
https://doi.org/10.1093/ajh/3.8.622
Autor:
Maria A. Palomo, Gillian M. Olins, G J Smits, K S Salles, Joan M. O'Neal, P R Bovy, Dennis R. Patton, A. J. Trapani, J P Koepke, Ellen G. Mcmahon
Publikováno v:
Journal of Medicinal Chemistry. 33:1477-1482
A series of analogues of the recently reported angiotensin II (AII) antagonist [Sar1]AII-(1-7)-amide or des-Phe8[Sar1]AII (3) have been prepared by solid-phase synthesis and purified by reverse-phase liquid chromatography. The agonist and antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1df0bc239548aec2e50ed2041de3888
https://doi.org/10.1021/jm00167a030
https://doi.org/10.1021/jm00167a030
Autor:
Anne Boney, J. P. Koepke, Erin Demo, Donald P. Frush, Priya S. Kishnani, Yuan-Tsong Chen, Deeksha Bali, Marcia R. Gottfried
Background/Aims Glycogen storage disease III (GSD III) is caused by a deficiency of glycogen-debranching enzyme which causes an incomplete glycogenolysis resulting in glycogen accumulation with abnormal structure (short outer chains resembling limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a941a825c22055a78045f1128d0a9d3f
https://europepmc.org/articles/PMC2683272/
https://europepmc.org/articles/PMC2683272/
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 18(1)
During acute angiotension II (Ang II) infusion (200 ng/kg/min i.v.) into anesthetized rats, mean arterial pressure rose from 124 +/- 1 to 154 +/- 2 mm Hg. The peptidic Ang II antagonist saralasin lowered arterial pressure in a dose-dependent manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457cc5536dfc287d2fa7ec77fbf479ae
https://pubmed.ncbi.nlm.nih.gov/1860708
https://pubmed.ncbi.nlm.nih.gov/1860708
Autor:
J R Schuh, Angelo J. Trapani, E G McMahon, J P Koepke, D. B. Reitz, P R Bovy, K S Salles, G M Olins, Edward H. Blaine
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 15(6 Pt 2)
Nonpeptidic imidazole derivatives were recently reported to be angiotensin II receptor antagonists with acute blood pressure-lowering activity. In the present study, we characterized the angiotensin II receptor antagonist properties of one such deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d89ae0801873fe4efc0144dd403586e
https://pubmed.ncbi.nlm.nih.gov/2190928
https://pubmed.ncbi.nlm.nih.gov/2190928
Autor:
P. A. Obrist, J. P. Koepke
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 245:R259-R264
The effects of inhibition of the renin-angiotensin system on the decreased renal excretion of sodium and water resulting from behavioral stress (shock avoidance) were examined in conscious saline-infused (4-5 ml/min) dogs. During saline infusion alon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86eb11b6d7a89f21fbbca7bb7eadf92
https://doi.org/10.1152/ajpregu.1983.245.2.r259
https://doi.org/10.1152/ajpregu.1983.245.2.r259
Autor:
G F DiBona, J P Koepke
Publikováno v:
Hypertension. 7:357-363
The effects of high sodium intake (drinking 0.9% NaCl for 15 days) on the increased renal sympathetic nerve activity and decreased urinary sodium excretion resulting from stressful environmental stimulation (air jet to head) were examined in consciou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c86475e084d75579d0a749b33e8986
https://doi.org/10.1161/01.hyp.7.3_pt_1.357
https://doi.org/10.1161/01.hyp.7.3_pt_1.357
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 245:R251-R258
The renal and neural mechanisms underlying the excretory response to behavioral stress (aversive conditioning) were examined in 30 conscious dogs. Twenty-one dogs decreased urine flow more than 20% during stress, whereas 9 dogs showed less than a 10%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e07784721137162687e01ab5454452
https://doi.org/10.1152/ajpregu.1983.245.2.r251
https://doi.org/10.1152/ajpregu.1983.245.2.r251
Autor:
G. F. DiBona, J. P. Koepke
Publikováno v:
American Journal of Physiology-Renal Physiology. 252:F865-F871
Renal responses to atrial natriuretic peptide were examined in conscious dogs with congestive heart failure (tricuspid insufficiency) and in conscious rats with nephrotic syndrome (adriamycin). Heart-failure dogs displayed elevated atrial pressure an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad76290dd98c0a5a5f29a6a18e6256b
https://doi.org/10.1152/ajprenal.1987.252.5.f865
https://doi.org/10.1152/ajprenal.1987.252.5.f865