Zobrazeno 1 - 10
of 61
pro vyhledávání: '"J P Huidobro-Toro"'
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
The vesicular nucleotide transporter (VNUT) is critical for sympathetic co-transmission and purinergic transmission maintenance. To examine this proposal, we assessed whether the bisphosphonate clodronate, claimed as a potent in vitro VNUT blocker, m
Externí odkaz:
https://doaj.org/article/6c1ca1f1c1a749b6b7276874584f5242
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 16 (2021)
Background The vascular pharmacodynamics of anthocyanins is only partially understood. To examine whether the anthocyanin‐induced vasorelaxation is related to membrane estrogen receptor activity, the role of ERα or GPER antagonism was ascertained
Externí odkaz:
https://doaj.org/article/88a98d808e3b4905a7e7db3f8ee8c89c
Autor:
J. Pablo Huidobro - Toro
Publikováno v:
ARS Medica, Vol 12, Iss 2, Pp 39-47 (2017)
Sin resumen
Externí odkaz:
https://doaj.org/article/8cfbe4f7025840e0835ea66af199b567
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Since the mechanism of human diabetic peripheral neuropathy and vascular disease in type 1 diabetes mellitus remains unknown, we assessed whether sympathetic transmitter overflow is altered by this disease and associated to vascular dysfunction. Diab
Externí odkaz:
https://doaj.org/article/b413bdba1c414ea4989d312f8290c746
Autor:
Fernando Valiente-Echeverría, Maricarmen Vallejos, Anne Monette, Karla Pino, Alejandro Letelier, J Pablo Huidobro-Toro, Andrew J Mouland, Marcelo López-Lastra
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56962 (2013)
Translation initiation from the human immunodeficiency virus type-1 (HIV-1) mRNA can occur through a cap or an IRES dependent mechanism. Cap-dependent translation initiation of the HIV-1 mRNA can be inhibited by the instability element (INS)-1, a cis
Externí odkaz:
https://doaj.org/article/554fc09d028f4c5a91f6531c82a0caac
Autor:
Elias Leiva-Salcedo, Claudio Coddou, Felipe E. Rodríguez, Antonello Penna, Ximena Lopez, Tanya Neira, Ricardo Fernández, Mónica Imarai, Miguel Rios, Jorge Escobar, Margarita Montoya, J. Pablo Huidobro-Toro, Alejandro Escobar, Claudio Acuña-Castillo
Publikováno v:
Mediators of Inflammation, Vol 2011 (2011)
The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimu
Externí odkaz:
https://doaj.org/article/70ed529568aa4b4d9626a6b70ddc95c5
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Although the physiological function of the cellular prion protein (PrPC) remains unknown, several evidences support the notion of its role in copper homeostasis. PrPC binds Cu2+ through a domain composed by four to five repeats of eight amino acids.
Externí odkaz:
https://doaj.org/article/08da6f19c4a64af28ba67d4f70b3755e
Autor:
Marcelo A. Chacón, J P Huidobro-Toro, María Inés Barría, Ramón A. Lorca, Nibaldo C. Inestrosa
Publikováno v:
Molecular Psychiatry. 8:853-862
Human cellular prion protein (PrP(C)) is involved in several neurodegenerative disorders; however, its normal function is unknown. We report here that a synthetic peptide corresponding to the four-octarepeat sequence of the PrP(C) (PrP(59-91)) protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513a7a54f273b4f10c1588642ba01609
https://doi.org/10.1038/sj.mp.4001400
https://doi.org/10.1038/sj.mp.4001400
Publikováno v:
Journal of Cellular Physiology. 184:409-420
Contraction and relaxation of smooth muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic guanosine monophosphate (cGMP) in mediating smooth muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a307f694cc8b6dec88e60d7838c2cf14
https://doi.org/10.1002/1097-4652(200009)184:3<409::aid-jcp16>3.0.co
https://doi.org/10.1002/1097-4652(200009)184:3<409::aid-jcp16>3.0.co
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:594-597
The inhibitory opioid activities of beta h-endorphin (beta h-EP), its structurally related peptide analogues [Gln8,Gly31]-beta h-EP-Gly-Gly-NH2 (Gly-Gly-beta h-EP), [Arg9,19,24,28,29]-beta h-EP (Arg-beta h-EP) and methionine enkephalin have been exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c5ce10e79134ac46bebac410e9045c
https://doi.org/10.1111/j.2042-7158.1991.tb03544.x
https://doi.org/10.1111/j.2042-7158.1991.tb03544.x