Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes

Autor: Nathalie Alet, Philippe Valet, Françoise Bono, Catherine Muller, J.-P. Herault, Cédric Dray, Paul J. Schaeffer, L. Millet, N. Delesque-Touchard, Isabelle Castan-Laurell, P. Savi, Oksana Kunduzova

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2008, 22 (12), pp.4146-53. ⟨10.1096/fj.07-104018⟩
FASEB Journal, 2008, 22 (12), pp.4146-53. ⟨10.1096/fj.07-104018⟩

International audience; Adipose tissue is an active endocrine organ that produces a variety of secretory factors involved in the initiation of angiogenic processes. The bioactive peptide apelin is the endogenous ligand of the G protein-coupled recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d79fe42c96b853c99733aa93eed016
https://doi.org/10.1096/fj.07-104018

Biochemical and Pharmacological Properties of SANORG 34006, a Potent and Long-Acting Synthetic Pentasaccharide

Autor: A Bernat, D.G. Meuleman, C. A. A. Van Boeckel, J.M. Herbert, J. P. Herault, M Petitou, J.C. Lormeau, Peter R. Hoffmann, van Rgm Amsterdam

Publikováno v: Blood : the Journal of Hematology, 91(11), 4179-4205. American Society of Hematology

SANORG 34006 is a new sulfated pentasaccharide obtained by chemical synthesis. It is an analog of the “synthetic pentasaccharide” (SR 90107/ ORG 31540) which represents the antithrombin (AT) binding site of heparin. SANORG 34006 showed a higher a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a595b9874c2713ce116b1abf796b384b
https://doi.org/10.1182/blood.v91.11.4197

Pharmacokinetic study of three synthetic AT-binding pentasaccharides in various animal species-extrapolation to humans

Autor: Jean-Marc Herbert, J. P. Herault, Donat F, J C Lormeau, B Crépon, A. Bernat, Bàrzu T

Publikováno v: Blood Coagulation & Fibrinolysis. 8:161-167

The 'synthetic pentasaccharide', SR 90107A/Org 31540 (SP) representing the minimal AT-binding sequence of heparin is a catalyst of factor Xa inhibition. Affinity of SP, Sanorg 32701 (32701) and SR 80027 (80027), two close analogues of SP for rat, rab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ac9bef7791938cb5a89e320f854732
https://doi.org/10.1097/00001721-199704000-00002

The Effect of the Synthetic Pentasaccharide SR 90107/ORG 31540 on Thrombin Generation Ex Vivo Is Uniquely due to ATIII-Mediated Neutralization of Factor Xa

Autor: J C Lormeau, J P Herault

Publikováno v: Thrombosis and Haemostasis. 74:1474-1477

SummaryThe inhibition of thrombin generation (TG) was studied in plasma from human volunteers after single subcutaneous administrations of 4000, 8000 or 12,000 anti-Xa units (i.e., 6, 12 or 18 mg) of the synthetic pentasaccharide (SR 90107/ORG 31540)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f9799a233a6c846324dfcfbd4e4ff27
https://doi.org/10.1055/s-0038-1649968

Synthesis of conformationally locked L-iduronic acid derivatives: direct evidence for a critical role of the skew-boat 2S0 conformer in the activation of antithrombin by heparin

Autor: S K, Das, J M, Mallet, J, Esnault, P A, Driguez, P, Duchaussoy, P, Sizun, J P, Herault, J M, Herbert, M, Petitou, P, Sinaÿ

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 7(22)

We have used organic synthesis to understand the role of L-iduronic acid conformational flexibility in the activation of antithrombin by heparin. Among known synthetic analogues of the genuine pentasaccharidic sequence representing the antithrombin b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dae2ada075a451fe1497bacb4fed44f2
https://pubmed.ncbi.nlm.nih.gov/11763451