Zobrazeno 1 - 10
of 42
pro vyhledávání: '"J P Flinois"'
Publikováno v:
British Journal of Anaesthesia. 80:788-795
Previous studies of propofol (2,6-diisopropylphenol) pharmacology have shown that this widely used anaesthetic drug is extensively cleared from the body by conjugation of the parent molecule or its quinol metabolite. On the basis of potential influen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9403167d302081af18fd65805da6b5ab
https://doi.org/10.1093/bja/80.6.788
https://doi.org/10.1093/bja/80.6.788
Autor:
Lionelle Nugon-Baudon, C Brézillon, Jacques Magdalou, V Ouriet, J.-P Flinois, S Bruel, Evelyne F. Lhoste, C Chèze
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 41(5)
As other xenobiotics, polyphenols are metabolized both by the endogenous detoxication system and the gut microflora. We hypothesized that the presence of a gut microflora may account for the effect of catechins on phase I and II xenobiotic-metabolizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba75975e054b3c7a666d48b0e1f9aabc
https://pubmed.ncbi.nlm.nih.gov/12659723
https://pubmed.ncbi.nlm.nih.gov/12659723
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(11)
The oral anticoagulant acenocoumarol is given as a racemic mixture. The (S)-enantiomer is rapidly cleared and is the reason why only (R)-acenocoumarol contributes to the pharmacological effect. The objective of the study was to establish the cytochro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7f8c8d9d1cf4a9e77b6c458e8497f6d
https://pubmed.ncbi.nlm.nih.gov/11038154
https://pubmed.ncbi.nlm.nih.gov/11038154
Publikováno v:
Pharmacogenetics. 9(1)
P450 S12, an engineered human P450 1A2 containing the 88-first amino-acids of the P450 1A1, demonstrates particularly high expression level in yeast while exhibiting catalytic properties very similar to the moderately expressed natural human P450 1A2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84caa3c30c7bb324703585efe2b2d0fe
https://pubmed.ncbi.nlm.nih.gov/10208644
https://pubmed.ncbi.nlm.nih.gov/10208644
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(1)
The aim of this study was to evaluate the (3S)-3-hydroxylation and the N-oxidation of quinidine as biomarkers for cytochrome P-450 (CYP)3A4 activity in human liver microsome preparations. An HPLC method was developed to assay the metabolites (3S)-3-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8301e08e53657d520d7a20031c0899bd
https://pubmed.ncbi.nlm.nih.gov/10086984
https://pubmed.ncbi.nlm.nih.gov/10086984
Autor:
F. P. Guengerich, Philippe Beaune, André Guillouzo, Fabrice Morel, J.-P. Flinois, D. Ratanasavanh
Publikováno v:
Toxicology in Vitro. 4:458-460
Primary cultures of adult human hepatocytes were used to determine the capability of the human liver to respond to phenobarbital, 3-methylcholanthrene, troleandomycin and rifampicin, four compounds known to be potent inducers of hepatic cytochrome P-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aab6872dcc49201b01213f80e6e9ba
https://doi.org/10.1016/0887-2333(90)90100-8
https://doi.org/10.1016/0887-2333(90)90100-8
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
The aim of the study was to identify the cytochrome P450s (CYPs) that catalyze the biotransformation of clomipramine in vitro. A high-performance liquid chromatography method was developed to assay N-desmethylclomipramine, 8-hydroxyclomipramine, 2-hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd89c76f199dbb7730952fc4d608a02a
https://pubmed.ncbi.nlm.nih.gov/8667235
https://pubmed.ncbi.nlm.nih.gov/8667235
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 261(1)
The in vitro metabolism of oxodipine was studied with rat and human hepatic and intestinal microsomes. Rat liver, human liver and intestine were able to metabolize oxodipine in vitro to the main metabolites found in vivo, namely pyridine and deesteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1ea710e82945fab7f0b120701633443
https://pubmed.ncbi.nlm.nih.gov/1560383
https://pubmed.ncbi.nlm.nih.gov/1560383
Publikováno v:
Hepatology (Baltimore, Md.). 13(6)
We have used immunohistochemical, immunoblotting and messenger RNA blotting approaches to study the distribution and quantitation of three cytochrome P-450 enzymes, namely P-450 IA2, P-450 IIC and P-450 IIIA and, for comparison, epoxide hydrolase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0cd2d351a9c7483d7f2ee135fbb08e10
https://pubmed.ncbi.nlm.nih.gov/1904834
https://pubmed.ncbi.nlm.nih.gov/1904834
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(3)
Caffeine biotransformation and four monooxygenase activities involving cytochrome P-450IA2, namely ethoxy- and methoxyresorufin O-dealkylases, phenacetin O-deethylase, and acetanilide 4-hydroxylation were studied in 25 human liver microsomes. All the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3eeda4c0872265ff8bfb6aafa625cdd
https://pubmed.ncbi.nlm.nih.gov/1680620
https://pubmed.ncbi.nlm.nih.gov/1680620