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Renal Operational Tolerance Is Associated With a Defect of Blood Tfh Cells That Exhibit Impaired B Cell Help

Autor: Mélanie Chesneau, S. Le Bot, Richard Danger, Alexis Chenouard, J. P. Soulillou, S. Malard‐Castagnet, L. Bui Nguyen, Nicolas Degauque, Sophie Brouard, Emilie Dugast, Magali Giral, P. Guerif, Chloé Paul, M. Cadoux, Simon Ville

Publikováno v: American Journal of Transplantation. 17:1490-1501

Renal operationally tolerant patients (TOL) display a defect in B cell differentiation, with a deficiency in plasma cells. Recently described, T follicular helper cells (Tfh) play a critical role in B cell differentiation. We analyzed blood Tfh subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb12b299d95cf80c45a33a84021ae95f
https://doi.org/10.1111/ajt.14142

203 SINGLE-STEP GENE EDITING OF 3 XENOANTIGENS IN PORCINE FIBROBLASTS USING PROGRAMMABLE NUCLEASES

Autor: J. P. Soulillou, Cesare Galli, G. Crotti, Giovanna Lazzari, Silvia Colleoni, Irina Lagutina, Roberto Duchi, Corinne Quadalti, Andrea Perota, Sophie Conchon, Jean-Paul Concordet, P. Turini

Programmable nucleases (ZFN, Tal Effector Nucleases, and CRISPR) opened a new era for mammal genome editing, in particular for the pigs used for xenotransplantation. Multiple gene editing events are required both for knockout (KO) of xenoantigens and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cef84581f20eb821d3a6bc4c4cf0ab4
http://hdl.handle.net/11585/574880

BAFF and BAFF-R Levels Are Associated With Risk of Long-Term Kidney Graft Dysfunction and Development of Donor-Specific Antibodies

Autor: Richard Danger, A. Devys, Thibault-Espitia A, J. P. Soulillou, Migone T, Magali Giral, G-Gueguen C, Annaïck Pallier, Yohann Foucher, Sophie Brouard, Stéphanie Castagnet, C-Gautier A

Publikováno v: American Journal of Transplantation. 12:2754-2762

There are lines of evidence that B cells may play a role in transplantation. B cell activating factor, BAFF, is a homotrimer that has been shown to play a role in B cell survival, maturation and activation. To date, little is known of the role of BAF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609fc7f20169577795ef25586b04489e
https://doi.org/10.1111/j.1600-6143.2012.04194.x

The Natural History of Clinical Operational Tolerance After Kidney Transplantation Through Twenty-Seven Cases

Autor: M. Ranbant, Andries J. Hoitsma, Evangeline Pillebout, Angelo Testa, J. P. Soulillou, C. Guillot-Guegen, Richard Danger, Claire Legendre, A. Devys, Annaïck Pallier, Le De Sagazan, F. Villemain, M.-C. Moal, C. Noël, L. Braun, Gwenaelle Roussey, Aline Garnier, Frederike J. Bemelman, S. Le Roux, Karine Renaudin, Anne Cesbron, Yohann Foucher, Jean Harb, Sophie Brouard, Giuseppe Orlando, C. Cantarell, Magali Giral, Jean-François Subra, H. Jambon, Joanna Ashton-Chess

Publikováno v: American Journal of Transplantation, 12, 12, pp. 3296-3307
American Journal of Transplantation, 12, 3296-3307
American journal of transplantation, 12(12), 3296-3307. Wiley-Blackwell
American Journal of Transplantation
American Journal of Transplantation, 2012, 12 (12), pp.3296-3307. ⟨10.1111/j.1600-6143.2012.04249.x⟩

Item does not contain fulltext We report here on a European cohort of 27 kidney transplant recipients displaying operational tolerance, compared to two cohorts of matched kidney transplant recipients under immunosuppression and patients who stopped i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c194e70c3790e8ae53c35d3dbce2b2
https://hdl.handle.net/2066/109734