Zobrazeno 1 - 10
of 25
pro vyhledávání: '"J P, Scovill"'
Autor:
J. P. Scovill, Michael Adler, Jason Piotrowski, Gerald W. Parker, Sharad S. Deshpande, Frank J. Lebeda
Publikováno v:
Toxicon. 33:527-537
The effects of the potassium channel inhibitor and putative botulinum toxin antagonist 3,4-diaminopyridine (3,4-DAP) were investigated in vitro on the contractile properties of rat diaphragm muscle. In the presence of 100 pM botulinum neurotoxin A (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4647a9008abf522103a14e2fee014ddd
https://doi.org/10.1016/0041-0101(94)00183-9
https://doi.org/10.1016/0041-0101(94)00183-9
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b7a8e04db450fde7c408f53014c9687
https://doi.org/10.1002/chin.199435273
https://doi.org/10.1002/chin.199435273
Publikováno v:
Military medicine. 162(8)
If military forces are required to operate in areas that are endemic for Chagas' disease, the occupation should be of critical concern. These areas, located in Central and South America, are many. The matter is of particular importance because no sui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::706db7a7b3006329a3e43eb6da08661e
https://pubmed.ncbi.nlm.nih.gov/9271903
https://pubmed.ncbi.nlm.nih.gov/9271903
Publikováno v:
Journal of computer-aided molecular design. 9(3)
Ricin is an RNA N-glycosidase that hydrolyzes a single adenine base from a conserved loop of 28S ribosomal RNA, thus inactivating protein synthesis. Molecular-dynamics simulation methods are used to analyze the structural interactions and thermodynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ea6ffbce357336dc07f822462f2f3a
https://pubmed.ncbi.nlm.nih.gov/7561975
https://pubmed.ncbi.nlm.nih.gov/7561975
Publikováno v:
Biomedica biochimica acta. 49(1)
N-Pyridinyl- and N-quinolinyl-ethyl substituted succinimide and phthalimide derivatives demonstrated significant hypolipidemic activity in rodents lowering both serum cholesterol and triglyceride levels at 20 mg/kg.day i.p. The pyridinyl, quinolinyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f0369ad792cad5bd69b8ab0c3354967
https://pubmed.ncbi.nlm.nih.gov/2360899
https://pubmed.ncbi.nlm.nih.gov/2360899
Publikováno v:
Phytotherapy Research. 8:121-122
The in vitro antiviral activity of a freeze‐dried methanolic extract of the bulbs of Zimbabwean Crinum macowanii was determined in Vero cells infected with a number of exotic RNA viruses. At a concentration of 32 μg/mL, the crude methanolic extrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c0b2de07b79247e73f3deff02f40242
https://doi.org/10.1002/ptr.2650080217
https://doi.org/10.1002/ptr.2650080217
Autor:
W. Nutakul, P. Kanchanapee, J. P. Scovill, J. L. Flippen-Anderson, R. Gilardi, T. Dechatiwongse, K. Yongvanitchit, K. Yoshihira, Katchrinnee Pavanand, C. George, H. K. Webster
Publikováno v:
Planta Medica. 52:108-111
The medicinal plant, BRUCEA JAVANICA (L.) Merr. (Simaroubaceae) was examined for antimalarial properties. Among different crude solvent extracts of the fruit, the chloroform extract was shown to have the most potent IN VITRO antimalarial activity. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65b0769f1d500b627c03357733b067b5
https://doi.org/10.1055/s-2007-969092
https://doi.org/10.1055/s-2007-969092
Publikováno v:
Journal of Medicinal Chemistry. 22:855-862
Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a3975e77643a4e0368c81442084cd7
https://doi.org/10.1021/jm00193a020
https://doi.org/10.1021/jm00193a020
Publikováno v:
Antimicrobial Agents and Chemotherapy. 18:317-322
Twenty-seven 2-acetylpyridine thiosemicarbazones and analogs were tested for antitrypanosomal activity against Trypanosoma rhodesiense using a semiautomated in vitro assay system. Activity was determined by relative inhibition of uptake of two radiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7912e65f4cd717389f7f47da8279096
https://doi.org/10.1128/aac.18.2.317
https://doi.org/10.1128/aac.18.2.317
Publikováno v:
Antimicrobial agents and chemotherapy. 18(1)
Antibacterial activity of 65 2-acetylpyridine thiosemicarbazones and related compounds was determined by using clinical isolates of nine bacterial genera. Minimal inhibitory concentrations (MICs) of 0.002 to 0.062 micrograms/ml were obtained with 23%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb876453987d11f042e50b1d5a11c20
https://pubmed.ncbi.nlm.nih.gov/7416748
https://pubmed.ncbi.nlm.nih.gov/7416748