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Absorption, distribution, metabolism, and excretion of dirlotapide in the dog

Autor: A. J. Bessire, D. A. Merritt, J. P. Sams, A. D. Vaz, M. P. Lynch

Publikováno v: Journal of Veterinary Pharmacology and Therapeutics. 30:17-23

Three once-daily oral doses of 0.2 mg/kg [(14)C]dirlotapide were administered to beagle dogs to study the absorption, distribution, metabolism, and excretion of dirlotapide. Mean (14)C recovered at 2.5 and 4.5 h after the last dose was 90%. Mean (14)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03e849d6b69f644e09e939ad072f8d1
https://doi.org/10.1111/j.1365-2885.2007.00865.x

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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Publikováno v: Journal of Medicinal Chemistry. 46:284-302

A new and promising group of antibacterial agents, collectively known as the oxazolidinones and exemplified by linezolid (PNU-100766, marketed as Zyvox), have recently emerged as important new therapeutic agents for the treatment of infections caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b367ff99342ae88e0043e780292f449
https://doi.org/10.1021/jm020248u

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Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog

Autor: J P Sams, Kenneth L. Feenstra, K. Chiba, S Yamazaki, M R Schuette, N. Ozawa, S Koike, J. G. Slatter, P T Daley-Yates, L A Adams, G. W. Peng, E C Bush

Publikováno v: Xenobiotica. 32:907-924

1. Linezolid (ZYVOX), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections. 2. The aim was to determine the absorption, distribution, metabolism and excretion (ADME) of linezolid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f8fa95fc172b89db3bc048187e732c
https://doi.org/10.1080/00498250210158249

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Assessment of radioactive residues arising from radiolabel instability in a multiple dose tissue distribution study in rats

Autor: Maria Courtney, John Alan Easter, John Gregory Slatter, Michael Dennis Koets, Brian Wayne Jones, Koji Chiba, Gwendolyn Deane Fate, J P Sams, Lorrie Renee Norris, Mark Johnson

Publikováno v: Biologicalpharmaceutical bulletin. 26(5)

Our study objectives were: To quantitatively determine the effect of radiolabel instability on terminal phase radioactive tissue residues in a multiple dose tissue distribution study. To quantitatively compare tissue residue artifacts (non drug-relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a30b60ca5ba66b82b41b63aa9531a5
https://pubmed.ncbi.nlm.nih.gov/12736492

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Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects

Autor: J G, Slatter, D J, Stalker, K L, Feenstra, I R, Welshman, J B, Bruss, J P, Sams, M G, Johnson, P E, Sanders, M J, Hauer, P E, Fagerness, R P, Stryd, G W, Peng, E M, Shobe

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(8)

Linezolid (Zyvox), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections, including resistant strains. The disposition of linezolid in human volunteers was determined, after a 500

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::877677956dba5cbdfabc07e05ce75c48
https://pubmed.ncbi.nlm.nih.gov/11454733

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Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients

Autor: J G, Slatter, L J, Schaaf, J P, Sams, K L, Feenstra, M G, Johnson, P A, Bombardt, K S, Cathcart, M T, Verburg, L K, Pearson, L D, Compton, L L, Miller, D S, Baker, C V, Pesheck, R S, Lord

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(4)

This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m(2) (100 microCi) [(14)C]CPT-11 in eight patients with solid tumors. Mean +/- S.D. recovery of radioactivity in urine and feces was 9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a052ff69246a2104d461df4a37672029
https://pubmed.ncbi.nlm.nih.gov/10725311

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Bioactivation of the anticancer agent CPT-11 to SN-38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions

Autor: J G, Slatter, P, Su, J P, Sams, L J, Schaaf, L C, Wienkers

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(10)

Human hepatic microsomes were used to investigate the carboxylesterase-mediated bioactivation of CPT-11 to the active metabolite, SN-38. SN-38 formation velocity was determined by HPLC over a concentration range of 0.25-200 microM CPT-11. Biphasic Ea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8a53fac21afcdf557c27c11829a2f41
https://pubmed.ncbi.nlm.nih.gov/9321519

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Lipidic nitrosating agents produced from atmospheric nitrogen dioxide and a nitrosamine produced in vivo from amyl nitrite

Autor: S S, Mirvish, M D, Ramm, D M, Babcook, J P, Sams, M, Panigot

Publikováno v: IARC scientific publications. (84)

In studies on nitrosating agent(s) formed in skin of mice exposed to nitrogen dioxide, we showed that: (i) N-nitrosomethylaniline was produced in skin of mice exposed to nitrogen dioxide and then painted with N-methylaniline; (ii) a nitrosating precu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e77e0e26f338c84a9db4431977f5cafc
https://pubmed.ncbi.nlm.nih.gov/2890579

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Effect of diet on fecal excretion and gastrointestinal tract distribution of unmetabolized benzo(a)pyrene and 3- methylcholanthrene when these compounds are administered orally to hamsters

Autor: S S, Mirvish, P, Ghadirian, L, Wallcave, C, Raha, S, Bronczyk, J P, Sams

Publikováno v: Cancer research. 41(6)

3-Methylcholanthrene (3MC) administered p.o. has induced tumors of the hamster gastrointestinal tract (GIT), including the large intestine. This process may depend on the concentration of unchanged hydrocarbon in the GIT contents. Benzo(a)pyrene (BP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f63d765feb4e976e95709f93697f39b8
https://pubmed.ncbi.nlm.nih.gov/6263463

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Nitrosamine formation from amines applied to the skin of mice after and before exposure to nitrogen dioxide

Autor: S S, Mirvish, M D, Ramm, J P, Sams, D M, Babcook

Publikováno v: Cancer research. 48(5)

Skin lipids of mice exposed to NO2 contain lipid-soluble nitrosating agent(s) (NSA) that react in vitro with amines to produce nitrosamines. To test whether this reaction occurs in skin, we exposed mice to 50 ppm NO2 for 4 h and, 20 h later, applied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be70ea2041ede4a235b1c03a193e5f1e
https://pubmed.ncbi.nlm.nih.gov/3342392

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