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From movement to motivation: a proposed framework to understand the antidepressant effect of exercise

Autor: E. J. Hird, A. Slanina-Davies, G. Lewis, M. Hamer, J. P. Roiser

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Depression is the leading cause of disability worldwide, exerting a profound negative impact on quality of life in those who experience it. Depression is associated with disruptions to several closely related neural and cognitive processes,

Externí odkaz: https://doaj.org/article/01efcb42aa4a4d0994af5499670aff5f

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Correction: Altered activation and connectivity in a hippocampal–basal ganglia–midbrain circuit during salience processing in subjects at ultra high risk for psychosis

Autor: Oliver D. Howes, Alice Egerton, Nico Bunzeck, Tobias Winton-Brown, Anthony A. Grace, André Schmidt, J. P. Roiser, Paolo Fusar-Poli, Phillip McGuire, Emrah Düzel, Shitij Kapur

Publikováno v: Translational Psychiatry. 8

This Article was originally published under Nature Research’s License to Publish, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the Article have been modified accordingly.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bd8cb441bdfff6b96c885de3cec8db5
https://doi.org/10.1038/s41398-018-0189-4

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Depression is associated with enhanced aversive Pavlovian control over instrumental behaviour

Autor: C L, Nord, R P, Lawson, Q J M, Huys, S, Pilling, J P, Roiser

Publikováno v: Scientific Reports

The dynamic modulation of instrumental behaviour by conditioned Pavlovian cues is an important process in decision-making. Patients with major depressive disorder (MDD) are known to exhibit mood-congruent biases in information processing, which may o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9050746c247366bf2396b2d1b24e0517
https://pubmed.ncbi.nlm.nih.gov/30135491

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Affective Biases in Humans and Animals

Autor: E S J, Robinson, J P, Roiser

Publikováno v: Current topics in behavioral neurosciences. 28

Depression is one of the most common but poorly understood psychiatric conditions. Although drug treatments and psychological therapies are effective in some patients, many do not achieve full remission and some patients receive no apparent benefit.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c516473438d3ff136ec46591e7548bac
https://pubmed.ncbi.nlm.nih.gov/27660073

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Salience attribution and its relationship to cannabis-induced psychotic symptoms

Autor: M A P, Bloomfield, E, Mouchlianitis, C J A, Morgan, T P, Freeman, H V, Curran, J P, Roiser, O D, Howes

Publikováno v: Psychological Medicine

Background Cannabis is a widely used drug associated with increased risk for psychosis. The dopamine hypothesis of psychosis postulates that altered salience processing leads to psychosis. We therefore tested the hypothesis that cannabis users exhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::547562a12bcfa7ddc94fb609c8ddd10b
https://pubmed.ncbi.nlm.nih.gov/27628967

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Altered activation and connectivity in a hippocampal–basal ganglia–midbrain circuit during salience processing in subjects at ultra high risk for psychosis

Autor: T, Winton-Brown, A, Schmidt, J P, Roiser, O D, Howes, A, Egerton, P, Fusar-Poli, N, Bunzeck, A A, Grace, E, Duzel, S, Kapur, P, McGuire

Publikováno v: Translational Psychiatry

Animal models of psychosis propose that abnormal hippocampal activity drives increased subcortical dopamine function, which is thought to contribute to aberrant salience processing and psychotic symptoms. These effects appear to be mediated through c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5343a0341a4ce3902e18380af72ef8cf
http://europepmc.org/articles/PMC5682600

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P-800 - How do antidepressants work? A Positron Emission Tomography (PET) study of brain serotonin levels and affect regulation

Autor: Oliver D. Howes, Lula Rosso, P J Cowen, Paul Faulkner, Elias Mouchlianitis, Federico Turkheimer, J. P. Roiser, Sudhakar Selvaraj

Publikováno v: European Psychiatry. 27:1

Background Serotonin (5-HT) is thought to be critical for affect regulation in the brain and many antidepressants are thought to primarily work by altering 5-HT levels. However there has not been a validated means of directly imaging of endogenous 5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f97cfcfc0aa563609e22a8632ffe688
https://doi.org/10.1016/s0924-9338(12)74967-2

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