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Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells

Autor: K M, Hiller, J P, Mayben, K M, Bendt, G A, Manousos, K, Senger, H S, Cameron, B W, Weston

Publikováno v: Molecular carcinogenesis. 27(4)

Sialyl Lewis x and sialyl Lewis a are oncodevelopmental antigens involved in the pathogenesis of colon adenocarcinoma. Biosynthesis of these glycans is controlled by alpha(1,3/1,4)fucosyltransferases. We report the disruption of sialyl Lewis x/a bios

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ecf5377c984b8e779a068f1311be3d8
https://pubmed.ncbi.nlm.nih.gov/10747292

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Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells

Autor: B W, Weston, K M, Hiller, J P, Mayben, G A, Manousos, K M, Bendt, R, Liu, J C, Cusack

Publikováno v: Cancer research. 59(9)

The initial steps of leukocyte and tumor cell adhesion involve selectin receptor/ligand interactions. The selectin ligand components sialyl Lewis x and sialyl Lewis a are oncodevelopmental antigens involved in progression of adenocarcinoma. Interrupt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1bbe7956913681a37803d43ce25f39a
https://pubmed.ncbi.nlm.nih.gov/10232599

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