Výsledky vyhledávání - "J P, Maffrand"

Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats

Autor: Jean-Marc Herbert, Philip Janiak, J.-P. Bidouard, G. Le Fur, J P Maffrand, Bruno Poirier, I. Barbosa, L. Gouraud, S. E. O'Connor, C. Cadrouvele, J. Dedio, F. Pierre

Publikováno v: Kidney International. 72(11):1345-1357

Obesity is a major risk factor in the development of chronic renal failure. Rimonabant, a cannabinoid CB1 receptor antagonist, improves body weight and metabolic disorders; however, its effect on mortality and chronic renal failure associated with ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd510d4462f991bd4145448e4f44c0e6

Zobrazit plný text záznamu

The Cannabinoid CB1Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells

Autor: Magali Gary-Bobo, Philippe Soubrie, G Le Fur, Arnaud Esclangon, J P Maffrand, F. Oury-Donat, Mohammed Bensaid

Publikováno v: Molecular Pharmacology. 63:908-914

This study investigates the effects of SR141716, a selective CB(1) receptor antagonist that reduces food intake and body weight of rodents, on Acrp30 mRNA expression in adipose tissue. Acrp30, a plasma protein exclusively expressed and secreted by ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f557493480b04ddad9e021a8db064592
https://doi.org/10.1124/mol.63.4.908

Zobrazit plný text záznamu

Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V 1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders

Autor: J P Maffrand, Jean Wagnon, Claudine Serradeil-Le Gal, Jacques Simiand, Guy Griebel, Bernard Scatton, Marc Pascal, Philippe Soubrie

Publikováno v: Proceedings of the National Academy of Sciences. 99:6370-6375

The limbic localization of the arginine vasopressin V 1b receptor has prompted speculation as to a potential role of this receptor in the control of emotional processes. To investigate this possibility, we have studied the behavioral effects of SSR14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf991ff7bbb0d9a1467f18128d4a79f
https://doi.org/10.1073/pnas.092012099

Zobrazit plný text záznamu

Characterization of (2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1bReceptor Antagonist

Autor: Rebecca M. Pruss, Claude Barberis, Jacques Simiand, Colette Lacour, D. Nisato, Gabrielle Brossard, Philippe Soubrie, Jean Wagnon, Guy Griebel, Claudine Serradeil-Le Gal, Gérard Le Fur, J P Maffrand, Marc Pascal, Bernard Scatton, Gilles Guillon

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 300:1122-1130

(2S,4R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), the first selective, nonpeptide vasopressin V1b receptor antagonist yet describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58f67d43bd81433e1f53f82c12eebbf4
https://doi.org/10.1124/jpet.300.3.1122

Zobrazit plný text záznamu

Selective blockade of vasopressin V2 receptors reveals significant V2‐mediated water reabsorption in Brattleboro rats with diabetes insipidus

Autor: Gérard Le Fur, Brigitte Pouzet, Claudine Serradeil-Le Gal, Lise Bankir, Nadine Bouby, J P Maffrand

Publikováno v: Nephrology Dialysis Transplantation. 16:725-734

Background. In a previous study we observed that acute administration of the selective antagonist of vasopressin (AVP) V 2 receptors, SR 121463A (SR), aggravated the symptoms of diabetes insipidus (DI) in homozygous Brattleboro rats (an AVP-deficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc2200addcea848ad77e9fe74e41514
https://doi.org/10.1093/ndt/16.4.725

Zobrazit plný text záznamu

Biochemical and pharmacological activities of SR 144190, a new potent non-peptide tachykinin NK2 receptor antagonist

Autor: G. Le Fur, S Daoul, J.C. Brelière, D. Van Broeck, M. Poncelet, Charles Advenier, Jean-Philippe Ducoux, Marco Landi, Emmanuel Naline, C Cognon, Philippe Soubrie, Vincenzo Proietto, X. Emonds-Alt, P. Vilain, Gervais Neliat, J P Maffrand, T. Croci

Publikováno v: Neuropeptides. 31:449-458

(R)-3-(1-[2-(4-benzoyl-2-(3,4-difluorophenyl)-morpholin-2-yl)- ethyl]-4-phenylpiperidin-4-yl)-1-dimethylurea (SR 144190) is a new non-peptide antagonist of tachykinin NK2 receptors. SR 144190 potently and selectively inhibited neurokinin A binding to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635453df0e79e08dfa3ea9112dc64bd6
https://doi.org/10.1016/s0143-4179(97)90039-1

Zobrazit plný text záznamu

Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24

Autor: Gérard Le Fur, Caroline Poinot-Chazel, Florence Pecceu, M. Portier, J P Maffrand, John G. Monroe, Monsif Bouaboula, P. Casellas, Natalio Vita, Danielle Gully

Publikováno v: Biochemical Journal. 320:145-151

Neurotensin (NT) is a neuropeptide that is important in a variety of biological processes such as signal transduction and cell growth. NT effects are mediated by a single class of cell-surface receptors, known as neurotensin receptors (NTRs), which e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efe94f41b77406c469980e2afe43d9b
https://doi.org/10.1042/bj3200145

Zobrazit plný text záznamu

Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators

Autor: Maurice Petitou, J. C. Lormeau, Jacques P. Caen, Marc Pascal, Zhongchao Han, S. Bellucci, Z. X. Shen, J. P. Maffrand

Publikováno v: Journal of Cellular Physiology. 168:97-104

We have previously reported that heparin is capable of stimulating in vitro and in vivo megakaryocytopoiesis in mice and has a thrombopoietic effect when given in chronic immune thrombocytopenic purpura and that heparin and several other glycosaminog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::197d211c84803b95cca0443e7c28435e
https://doi.org/10.1002/(sici)1097-4652(199607)168:1<97::aid-jcp12>3.0.co

Zobrazit plný text záznamu

[3H]-SR 27897B: A Selective Probe for Autoradiographic Labelling of CCK-A Receptors in the Brain

Autor: J M Zajac, J P Maffrand, D Gully

Publikováno v: Journal of Receptors and Signal Transduction. 16:93-113

The binding and distribution of radiolabelled SR27897B, a potent CCK-A antagonist, was characterized using in vitro receptor autoradiography. Rapid imaging and quantitative analysis of [3H]SR27897B binding was obtained in a very short period of time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b77b9ae338168d221a1c287bf97b74
https://doi.org/10.3109/10799899609039943

Zobrazit plný text záznamu

Cross-reactivity of human molecular markers for detection of prethrombotic states in various animal species

Autor: C. Legrand, Jean-Pierre Cazenave, Catherine Ravanat, Ludovic Drouet, J P Maffrand, F. Incardona, M. Freund, B. Boneu, Jean-Marc Herbert, Y. Cadroy, F. Dol, Jacqueline Roussi

Publikováno v: Blood Coagulation & Fibrinolysis. 6:446-455

The aim of the present study was to investigate the reactivity of immunoreagents developed for clinical applications in humans in different animal species (hen, mouse, rat, rabbit, guinea-pig, dog, pig, sheep, baboon). Prothrombin fragment 1 + 2, thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4067d84d92ef0496ab05185ab70c52e4
https://doi.org/10.1097/00001721-199507000-00012

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání