Zobrazeno 1 - 10
of 75
pro vyhledávání: '"J P, Jaffrézou"'
Publikováno v:
Cancer research. 61(6)
Anthracyclines are, above all, DNA intercalators, which induce genetic damage leading to cell death. However, increasing evidence firmly suggests that the underlying mechanism for anthracycline cytotoxicity is the induction of apoptosis through intra
Publikováno v:
Chemistry and physics of lipids. 102(1-2)
The ubiquitous sphingophospholipid sphingomyelin (SM) can be hydrolysed in human cells to ceramide by different sphingomyelinases (SMases). These enzymes exert a dual role, enabling not only the turnover of membrane SM and the degradation of exogenou
Autor:
J P, Jaffrézou, G, Laurent
Publikováno v:
Journal de la Societe de biologie. 193(4-5)
Simple clinical observation suggests that while anti-leukemia agents are efficient at eradicating blasts cells in terminal division, as illustrated, in the case of acute myeloid leukemia, by the high complete remission rate (70%); these agents are re
Autor:
T, Levade, J P, Jaffrézou
Publikováno v:
Biochimica et biophysica acta. 1438(1)
A major lipid signalling pathway in mammalian cells implicates the activation of sphingomyelinase (SMase), which upon cell stimulation hydrolyses the ubiquitous sphingophospholipid sphingomyelin to ceramide. This review summarizes our current knowled
Publikováno v:
Leukemia. 9(5)
In a panel of acute myeloblastic leukemia (AML) cell lines, representative of distinct differentiation stages, we investigated the possible correlation between drug-resistance and both expression and function of the multidrug resistance (MDR)-related
Autor:
J P, Jaffrézou, C, Dumontet, W B, Derry, G, Durán, K G, Chen, E, Tsuchiya, L, Wilson, M A, Jordan, B I, Sikic
Publikováno v:
Oncology research. 7(10-11)
A paclitaxel-resistant cell line, KPTA5, was established by co-selecting the parental erythroleukemic cell line K562 with stepwise increased concentrations of paclitaxel (Taxol) in the presence of the cyclosporin D analogue PSC 833 (2 microM), a pote
Publikováno v:
Cancer research. 54(18)
Fluctuation analysis experiments were performed in the human sarcoma cell line MES-SA to assess whether selection or induction mechanisms determine resistance to doxorubicin (DOX), mutation rates, and the nature of the surviving clones. Thirteen flas
Autor:
D, Schlaifer, K, Meyer, C, Muller, M, Attal, M T, Smith, S, Tamaki, J, Weimels, J, Pris, J P, Jaffrézou, G, Laurent
Publikováno v:
Leukemia. 8(2)
Myeloperoxidase (MPO), a heme-peroxidase found in the HL-60 myeloblastic cell line, is involved in vincristine (VCR) metabolism and the inactivation of this drug. We have examined whether decreased MPO activity correlated with increased sensitivity t
Autor:
J, Laredo, C, Demur, C, Muller, S, Saivin, G, Cassar, C, Bousquet, N, Dastugue, J P, Jaffrézou, P, Colombies, G, Laurent
Publikováno v:
Leukemia. 7(6)
In this study, we compared the impact of two protein kinase (PK) inhibitors, H-7 and staurosporine, on the normal myeloid progenitors (CFU-GM) and acute myeloid leukemia progenitors (AML-CFU) proliferation measured by in vitro clonogenic assay. H-7 a
Publikováno v:
Cancer research. 52(23)
The impact of the novel chemosensitizer ((2-isopropyl-1-(4-[3-N-methyl-N-(3,4-dimethoxy-beta- phenethyl)amino]propyloxy)benzenesulfonyl))indolizine (SR33557) on the intracellular distribution of doxorubicin (DOX) within the multidrug-resistant murine